Systems and methods for ex vivo lung care
First Claim
1. A lung chamber assembly comprising:
- a housing having a bottom surface defining a first housing drain, and walls,wherein the bottom surface defines a pooling region proximate to the first housing drain to collect perfusion fluid draining from a lung, andwherein the bottom surface defines an overflow region proximate to the pooling region to collect overflow perfusion fluid from the pooling region;
a support surface for supporting a lung, the support surface defining a support surface drain for draining a perfusion fluid exiting the lung to the first housing drain;
a flexible wrap configured to wrap around the lung and maintain the lung in a physiologic configuration, the flexible wrap comprising one or more holes for draining perfusate from the lung to the support surface;
an openable lid that provides a sealable connection to the walls of the housing;
a first perfusion interface for allowing a flow of the perfusion fluid into the lung;
a ventilation interface that allows for ventilation of the lung by a ventilator device; and
a second perfusion interface for allowing a flow of the perfusion fluid away from the lung.
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Accused Products
Abstract
Methods and systems of maintaining, evaluating, and providing therapy to a lung ex vivo. The methods and systems involve positioning the lung in an ex vivo perfusion circuit; circulating a perfusion fluid through the lung, the fluid entering the lung through a pulmonary artery interface and leaving the lung through a left atrial interface; and ventilating the lung by flowing a ventilation gas through a tracheal interface. Maintaining the lung for extended periods involves causing the lung to rebreath a captive volume of air, and reaching an equilibrium state between the perfusion fluid and the ventilation gas. Evaluating the gas exchange capability of the lung involves deoxygenating the perfusion fluid and measuring a time taken to reoxygenate the perfusion fluid by ventilating the lung with an oxygenation gas.
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Citations
23 Claims
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1. A lung chamber assembly comprising:
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a housing having a bottom surface defining a first housing drain, and walls, wherein the bottom surface defines a pooling region proximate to the first housing drain to collect perfusion fluid draining from a lung, and wherein the bottom surface defines an overflow region proximate to the pooling region to collect overflow perfusion fluid from the pooling region; a support surface for supporting a lung, the support surface defining a support surface drain for draining a perfusion fluid exiting the lung to the first housing drain; a flexible wrap configured to wrap around the lung and maintain the lung in a physiologic configuration, the flexible wrap comprising one or more holes for draining perfusate from the lung to the support surface; an openable lid that provides a sealable connection to the walls of the housing; a first perfusion interface for allowing a flow of the perfusion fluid into the lung; a ventilation interface that allows for ventilation of the lung by a ventilator device; and a second perfusion interface for allowing a flow of the perfusion fluid away from the lung. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22)
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23. A lung chamber assembly comprising:
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a housing having a bottom surface including at least one housing drain, and walls; a support surface for supporting a lung, the support surface defining a drain for draining a perfusion fluid exiting the lung to the first housing drain; a flexible wrap configured to wrap around the lung and maintain the lung in a physiologic configuration, the flexible wrap comprising one or more holes for draining perfusate from the lung to the support surface; an openable lid that provides a sealable connection to the walls of the housing; a first perfusion interface for allowing a flow of the perfusion fluid into the lung; a ventilation interface that allows ventilation of the lung by a ventilator; and a second perfusion interface for allowing a flow of the perfusion fluid away from the lung; wherein the first perfusion interface includes at least one connector portion, and at least one insertion tube attached to a distal end of the connector portion and disposed at an angle relative to the connection portion, and wherein the insertion tube is made of a bio inert material having a hardness between about 50 Shore A and 90 Shore A for suturing the insertion tube to a pulmonary artery.
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Specification