System and methods for automatic processing of digital retinal images in conjunction with an imaging device
First Claim
1. A method to perform automatic retinal screening, the method comprising the steps of:
- illuminating a retina using an illumination source;
capturing a digital retinal image with a retinal camera supported by a platform;
transmitting the digital retinal image to a processor;
performing via the processor an assessment in real time of the image quality wherein image quality is determined by one or more of the image quality steps of;
determining a position of the Optical Disc or Macula relative to the digital retinal image obtained;
determining percent of total pixels obscured by shadowing; and
determining the value of the third quartile of a histogram of a gradient of pixel values from the digital retinal image;
adjusting the digital retinal camera if the image quality does not meet predetermined image quality requirements; and
executing real time analysis of presence or absence of disease in the digital retinal imagewherein the digital retinal image is inadequate to meet the predetermined image quality requirement when one or more of the following is present;
i) the number of pixels in the third quartile of a gradient image of the digital retinal image occupies more than 15 percent of the image area, ii) the total number of pixels within 10 percent of saturation is larger than 25 percent of the total number of pixels in the image after inverting values of a thresholded image, iii) a macula position is at an angle greater than between 0 degree and 20 degrees below a position of an optic disc with respect to a horizontal axis of the digital retinal image, iv) a distance between an optic disc center and a macula is more than two optic disc diameters and less than three optic disc diameters, v) an optic disc and a macula are positioned within one-third and two-thirds sections of a vertical digital image, and vi) a macula is positioned within a vertical region limited by temporal vessel arcades.
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Accused Products
Abstract
Systems and methods of obtaining and recording fundus images by minimally trained persons, which includes a camera for obtaining images of a fundus of a subject'"'"'s eye, in combination with mathematical methods to assign real time image quality classification to the images obtained based upon a set of criteria. The classified images will be further processed if the classified images are of sufficient image quality for clinical interpretation by machine-coded and/or human-based methods. Such systems and methods can thus automatically determine whether the quality of a retinal image is sufficient for computer-based eye disease screening. The system integrates global histogram features, textural features, and vessel density, as well as a local non-reference perceptual sharpness metric. A partial least square (PLS) classifier is trained to distinguish low quality images from normal quality images.
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Citations
26 Claims
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1. A method to perform automatic retinal screening, the method comprising the steps of:
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illuminating a retina using an illumination source; capturing a digital retinal image with a retinal camera supported by a platform; transmitting the digital retinal image to a processor; performing via the processor an assessment in real time of the image quality wherein image quality is determined by one or more of the image quality steps of; determining a position of the Optical Disc or Macula relative to the digital retinal image obtained; determining percent of total pixels obscured by shadowing; and determining the value of the third quartile of a histogram of a gradient of pixel values from the digital retinal image; adjusting the digital retinal camera if the image quality does not meet predetermined image quality requirements; and executing real time analysis of presence or absence of disease in the digital retinal image wherein the digital retinal image is inadequate to meet the predetermined image quality requirement when one or more of the following is present;
i) the number of pixels in the third quartile of a gradient image of the digital retinal image occupies more than 15 percent of the image area, ii) the total number of pixels within 10 percent of saturation is larger than 25 percent of the total number of pixels in the image after inverting values of a thresholded image, iii) a macula position is at an angle greater than between 0 degree and 20 degrees below a position of an optic disc with respect to a horizontal axis of the digital retinal image, iv) a distance between an optic disc center and a macula is more than two optic disc diameters and less than three optic disc diameters, v) an optic disc and a macula are positioned within one-third and two-thirds sections of a vertical digital image, and vi) a macula is positioned within a vertical region limited by temporal vessel arcades. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18)
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19. A system to perform automatic retinal screening, said system comprising:
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an illumination source illuminating a retina; a retinal camera capturing a retinal image wherein the retinal camera is supported by a platform; a processor receiving the image and performing an assessment in real time of the image quality; and adjusting a setting of the camera if the image quality does not meet predetermined quality requirements.
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20. A method to automatically determine image quality of a digital retinal image, the method comprising the steps of:
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illuminating a retina using an illumination source; capturing the digital retinal image with a retinal camera supported by a platform; transmitting the image to a processor; performing via the processor an assessment in real time of the image quality, comprising; determining alignment of the image according to one or more imaging protocols; determining presence and extent of crescents and shadows in the image; determining quantitative image quality of the image via a classification process trained using examples of visual perception by human experts; and adjusting the camera if the image quality does not meet a predetermined quality requirement. - View Dependent Claims (21, 22, 23, 24, 25, 26)
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Specification