Methods of lag-compensation for analyte measurements, and devices related thereto
First Claim
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1. A method of determining glucose level in a subject, comprising:
- inserting an in vivo sensor in subcutaneous tissue in contact with interstitial fluid of a subject;
positioning an on-body unit on a surface of skin of the subject, wherein the on-body unit is in electrical contact with the in vivo sensor and in communication with a display;
measuring glucose in the interstitial fluid of the subject with the in vivo glucose sensor to produce at least three uncompensated glucose measurements, wherein the three uncompensated glucose measurements including a first uncompensated glucose measurement at an initial reference time, a second uncompensated glucose measurement at a first prior reference time, and a third uncompensated glucose measurement at a second prior reference time;
determining a first scaled rate-of-change by multiplying a first weighting coefficient on a first rate of change computed from the first uncompensated glucose measurement at the initial reference time relative to the second uncompensated glucose measurement at the first prior reference time;
determining a second scaled rate-of-change by multiplying a second weighting coefficient on a second rate of change computed from the first uncompensated glucose measurement at the initial reference time relative to the second uncompensated glucose measurement at the second prior reference time; and
calculating a lag-compensated glucose level from the uncompensated glucose measurements by adding the first scaled rate-of-change, the second scaled rate-of-change and the first uncompensated glucose measurement; and
displaying the lag compensated glucose level to the subject on the display, wherein the lag-compensated glucose level correlates with the subject'"'"'s blood glucose level at the initial reference time.
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Abstract
In some aspects, methods of lag compensation of analyte measurements are provided. Methods of lag-compensation are provided for analyte point measurements and/or for analyte rate-of-change measurements. The methods include receiving a series of uncompensated analyte measurements and determining parameter values for analyte point and/or rate-of-change estimates based on reference analyte measurements. The analyte rate-of-change estimate is based on a sum of a plurality of scaled rates-of-changes. The analyte point estimate is based on a sum of an analyte point and a sum of a plurality of scaled rates-of-changes. Devices related to the methods are also provided.
72 Citations
62 Claims
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1. A method of determining glucose level in a subject, comprising:
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inserting an in vivo sensor in subcutaneous tissue in contact with interstitial fluid of a subject; positioning an on-body unit on a surface of skin of the subject, wherein the on-body unit is in electrical contact with the in vivo sensor and in communication with a display; measuring glucose in the interstitial fluid of the subject with the in vivo glucose sensor to produce at least three uncompensated glucose measurements, wherein the three uncompensated glucose measurements including a first uncompensated glucose measurement at an initial reference time, a second uncompensated glucose measurement at a first prior reference time, and a third uncompensated glucose measurement at a second prior reference time; determining a first scaled rate-of-change by multiplying a first weighting coefficient on a first rate of change computed from the first uncompensated glucose measurement at the initial reference time relative to the second uncompensated glucose measurement at the first prior reference time; determining a second scaled rate-of-change by multiplying a second weighting coefficient on a second rate of change computed from the first uncompensated glucose measurement at the initial reference time relative to the second uncompensated glucose measurement at the second prior reference time; and calculating a lag-compensated glucose level from the uncompensated glucose measurements by adding the first scaled rate-of-change, the second scaled rate-of-change and the first uncompensated glucose measurement; and displaying the lag compensated glucose level to the subject on the display, wherein the lag-compensated glucose level correlates with the subject'"'"'s blood glucose level at the initial reference time. - View Dependent Claims (2, 3, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35)
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4. A device, comprising:
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an in vivo positionable glucose sensor; a processor, a display for communicating lag compensated glucose level, wherein the lag compensated glucose level correlates with the subject'"'"'s blood glucose level at an initial reference time and a memory comprising machine-executable instructions stored thereon for lag compensation of glucose level measurements, the instructions when executed cause the processor to; receive at least three uncompensated glucose measurements prior to lag compensation, wherein the three uncompensated glucose measurements including a first uncompensated glucose measurement at the initial reference time, a second uncompensated glucose measurement at a first prior reference time, and a third uncompensated glucose measurement at a second prior reference time; and determine a first scaled rate-of-change by multiplying a first weighting coefficient on a first rate of change computed from the first uncompensated glucose measurement at the initial reference time to the second uncompensated glucose measurement at the first prior reference time and determine a second scaled rate-of-change by multiplying a second weight coefficient on a second rate of change computed from the first uncompensated glucose measurement at the initial reference time to the second uncompensated glucose measurement at the second prior reference time; and calculate lag-compensated glucose level measurements from the uncompensated glucose measurements by adding the first scaled rate-of-change, the second scaled rate-of-change and the first uncompensated glucose measurement. - View Dependent Claims (5, 6, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62)
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Specification