Apparatus, method and computer readable code for forecasting the onset of potentially life-threatening disease
First Claim
1. A method of advancing detection of a condition of sepsis in a premature infant by at least 18 hours, comprising:
- a) using physiological sensors to acquire a plurality of different vital sign parameters of an infant, and providing measurement values to one or more processors of the plurality of different vital sign parameters of the infant, the plurality of different vital signs including a temperature parameter, a heart rate parameter, a respiration parameter, a desaturation parameter, a bradycardia parameter and a body weight parameter, the physiological sensors for the temperature parameter, the heart rate parameter, the respiration parameter, the desaturation parameter and the bradycardia parameter connected to the one or more processors;
b) the one or more processors normalizing measurement values of the plurality of different vital signs including, for at least some of the different vital sign parameters of the infant, against historical values for said infant, the one or more processors transforming said normalized value;
c) the one or more processors combining the transformed measurement values of the plurality of different vital sign parameters and thereby generating a single sepsis parameter, the single sepsis parameter comprising a single variable having a variable numerical value;
d) the one or more processors monitoring the single sepsis parameter of the infant over time; and
e) the one or more processors detecting a deviation from a normal range indicating the condition of sepsis in the infant from said single sepsis parameter when the single sepsis parameter moves beyond the normal range, said detecting the deviation advancing detection of the condition of sepsis in the infant by at least 18 hours.
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Abstract
Methods, systems and computer-readable code for generating a forecast of a life-threatening condition, for example sepsis, in a subject, for example an infant, are disclosed. According to some embodiments, the forecast is generated in accordance with measurement values for a plurality of different vital sign parameters. In exemplary embodiments, vital sign parameters from a plurality of physiological systems are used to generate the forecast of the life-threatening condition. In exemplary embodiments, at least one vital sign parameter is other than a cardiac parameter. Non-limiting exemplary vital sign parameters may include one or more of a heart rate parameter, a respiration rate parameter, a bradycardia parameter, a desaturation parameter, a temperature parameter (for example, body temperature) and a body mass parameter.
18 Citations
26 Claims
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1. A method of advancing detection of a condition of sepsis in a premature infant by at least 18 hours, comprising:
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a) using physiological sensors to acquire a plurality of different vital sign parameters of an infant, and providing measurement values to one or more processors of the plurality of different vital sign parameters of the infant, the plurality of different vital signs including a temperature parameter, a heart rate parameter, a respiration parameter, a desaturation parameter, a bradycardia parameter and a body weight parameter, the physiological sensors for the temperature parameter, the heart rate parameter, the respiration parameter, the desaturation parameter and the bradycardia parameter connected to the one or more processors; b) the one or more processors normalizing measurement values of the plurality of different vital signs including, for at least some of the different vital sign parameters of the infant, against historical values for said infant, the one or more processors transforming said normalized value; c) the one or more processors combining the transformed measurement values of the plurality of different vital sign parameters and thereby generating a single sepsis parameter, the single sepsis parameter comprising a single variable having a variable numerical value; d) the one or more processors monitoring the single sepsis parameter of the infant over time; and e) the one or more processors detecting a deviation from a normal range indicating the condition of sepsis in the infant from said single sepsis parameter when the single sepsis parameter moves beyond the normal range, said detecting the deviation advancing detection of the condition of sepsis in the infant by at least 18 hours. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21)
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22. An apparatus for detecting a condition of sepsis in a premature infant, the apparatus comprising:
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a) a data storage unit for storing measurement values for a plurality of different vital sign parameters of an infant, the data storage unit connected to physiological sensors for acquiring the plurality of different vital sign parameters; and b) a data processing unit in communication with the data storage unit to receive the measurement values, the data processing unit including one or more processors configured to normalize each measurement value, for each of the different vital sign parameters that is not a bradycardia parameter, against historical values for said infant, the one or more processors configured to transform or leave untransformed each of said normalized or un-normalized values, the one or more processors also configured to combine any said transformed and untransformed normalized values and any said transformed and untransformed un-normalized values, of the plurality of different vital sign parameters and thereby generate a single sepsis parameter, the single sepsis parameter comprising a single variable having a variable numerical value, and the data processing unit also configured to monitor the single sepsis parameter of the premature infant over time and generate an output indicating a likelihood of the condition of sepsis in the infant from said single sepsis parameter when the single sepsis parameter reaches beyond a normal range, said generating the output advancing detection of the condition of sepsis in the infant by at least 18 hours. - View Dependent Claims (23, 24)
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25. A non-transitory computer readable medium comprising program instructions for detecting a condition of sepsis in a premature infant, wherein when executed by one or more processors the program instructions are operable to:
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a) access measurement values of a plurality of different vital sign parameters of an infant, the plurality of different vital signs including a temperature parameter, a heart rate parameter, a respiration parameter, a desaturation parameter, a bradycardia parameter and a body weight parameter; b) normalize each of the temperature parameter, the heart rate parameter, the respiration parameter, the desaturation parameter, and the body weight parameter against historical values of the infant and transform said normalized or un-normalized values; combine the transformed measurement values of the plurality of different vital sign parameters and thereby generate a single sepsis parameter, the single sepsis parameter comprising a single variable having a variable numerical value; and c) generate a forecast of the life-threatening condition of sepsis in the infant from said single sepsis parameter when the single sepsis parameter reaches beyond a normal range, said forecast defined as occurring at least 18 hours in advance of a diagnosis derived from clinical and laboratory evidence.
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26. An apparatus for detecting a condition of sepsis in a premature infant, the apparatus comprising:
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a) a data storage unit for storing measurement values for a plurality of different vital sign parameters of an infant, the plurality of different vital signs including a temperature parameter, a heart rate parameter, a respiration parameter, a desaturation parameter, a bradycardia parameter and a body weight parameter, the data storage unit connected to physiological sensors for acquiring the temperature parameter, the heart rate parameter, the respiration parameter, the desaturation parameter and the bradycardia parameter; and b) a data processing unit in communication with the data storage unit to receive the measurement values, the data processing unit including one or more processors configured to normalize each measurement value including by normalizing at least some of the different vital sign parameters against historical values for said infant, the one or more processors configured to transform or leave untransformed each of said normalized values, the one or more processors also configured to combine any said transformed and untransformed normalized values, of the plurality of different vital sip parameters and thereby generate a single sepsis parameter, the single sepsis parameter comprising a single variable having a variable numerical value, and the data processing unit also configured to monitor the single sepsis parameter of the premature infant over time and generate an output indicating a likelihood of the condition of sepsis in the infant from said single sepsis parameter when the single sepsis parameter reaches beyond a normal range, said generating the output advancing detection of the condition of sepsis in the infant by at least 18 hours.
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Specification