Stabilized alpha helical peptides and uses thereof
First Claim
Patent Images
1. A cell-penetrable cross-linked polypeptide of Formula (I):
4 Assignments
0 Petitions
Accused Products
Abstract
Novel polypeptides and methods of making and using the same are described herein. The polypeptides include cross-linking (“hydrocarbon stapling”) moieties to provide a tether between two amino acid moieties, which constrains the secondary structure of the polypeptide. The polypeptides described herein can be used to treat diseases characterized by excessive or inadequate cellular death.
113 Citations
32 Claims
- 1. A cell-penetrable cross-linked polypeptide of Formula (I):
- 14. A method of promoting apoptosis of a neoplastic cell in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of a helical cross-linked polypeptide derived from a protein involved in a cellular apoptotic pathway, wherein the cross-linked polypeptide is of Formula (I):
Specification