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Engineered nucleic acids and methods of use thereof

  • US 9,464,124 B2
  • Filed: 11/05/2014
  • Issued: 10/11/2016
  • Est. Priority Date: 09/12/2011
  • Status: Active Grant
First Claim
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1. A pharmaceutical composition comprising:

  • a lipid-based nanoparticle comprising a synthetic messenger ribonucleic acid (mRNA) encoding a defensin polypeptide in an amount effective to permit production of the defensin polypeptide in a cell, wherein the synthetic mRNA comprises a translatable region that contains at least one nucleoside modification, and wherein 75-100% of uridine nucleotides in the synthetic mRNA are modified.

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