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RNA interference mediated inhibition of hepatitis B virus (HBV) gene expression using short interfering nucleic acid (siNA)

  • US 9,464,290 B2
  • Filed: 04/09/2015
  • Issued: 10/11/2016
  • Est. Priority Date: 08/17/2010
  • Status: Active Grant
First Claim
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1. A double-stranded short interfering nucleic acid (siNA) molecule comprising a sense strand comprising the nucleotide sequence 5′

  • -B CCGaUCCAUaCuGCGgAAcUsU B-3′

    (SEQ ID NO;

    289) and an antisense strand comprising the nucleotide sequence 5′

    -GUUccGcAGuAuGGAucGGUsU-3′

    (SEQ ID NO;

    246),wherein B is an inverted abasic moiety;

    the bolded nucleotides comprise 2′

    -O-methyl modifications, the lower case nucleotides comprise 2′

    -fluoro modifications, the italicized nucleotides are deoxynucleotides, and the s is a phosphorothioate linkage.

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