Systems and methods for sample use maximization
First Claim
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1. A method of detecting the presence or concentration of an analyte in a sample fluid contained in a container comprising:
- (a) illuminating the container along a first region having a first path length to yield a first measurement of light intensity transmitted across the first path length;
(b) determining that the first measurement falls outside a predetermined dynamic range of transmitted light intensity;
(c) moving the sample fluid to another region in the same container having another path length;
(d) illuminating the same container along the another region to yield another measurement of light intensity transmitted across the another path length; and
(e) repeating steps (c) and (d) as needed on the same container until a measurement of light intensity falls within the predetermined dynamic range, thereby detecting the presence or concentration of the analyte.
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Abstract
The present invention provides systems, devices, and methods for point-of-care and/or distributed testing services. The methods and devices of the invention are directed toward automatic detection of analytes in a bodily fluid. The components of the device can be modified to allow for more flexible and robust use with the disclosed methods for a variety of medical, laboratory, and other applications. The systems, devices, and methods of the present invention can allow for effective use of samples by improved sample preparation and analysis.
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19 Claims
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1. A method of detecting the presence or concentration of an analyte in a sample fluid contained in a container comprising:
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(a) illuminating the container along a first region having a first path length to yield a first measurement of light intensity transmitted across the first path length; (b) determining that the first measurement falls outside a predetermined dynamic range of transmitted light intensity; (c) moving the sample fluid to another region in the same container having another path length; (d) illuminating the same container along the another region to yield another measurement of light intensity transmitted across the another path length; and (e) repeating steps (c) and (d) as needed on the same container until a measurement of light intensity falls within the predetermined dynamic range, thereby detecting the presence or concentration of the analyte. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 19)
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12. A method of measuring an analyte concentration in a sample fluid comprising:
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(a) providing the sample contained in a container dimensioned with a plurality of distinct widths to permit transmission of light along a plurality of varying path lengths that correspond to the plurality of distinct widths; (b) illuminating the container along at least one of the plurality of path lengths; and (c) imaging the container to measure a first light intensity transmitted across said at least one of the plurality of path lengths, for the determination of the concentration of the analyte based on the measured first light intensity; (d) imaging the same container to measure a second light intensity transmitted across another path length corresponding to another distinct width of the container; (e) comparing said first light intensity and the second light intensity; and (f) determining an analyte concentration based on said comparing step. - View Dependent Claims (13, 14, 15, 16, 17, 18)
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Specification