Determining paced cardiac depolarization waveform morphological templates

• US 9,468,392 B2
• Filed: 02/06/2015
• Issued: 10/18/2016
• Est. Priority Date: 02/06/2015
• Status: Active Grant

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Jackson, Troy E.
• Primary Examiner(s): Layno, Carl H
• Assistant Examiner(s): Piateski, Erin M
• Application Number:
  US14/615,699
• Publication Number:
  US 20160228026A1
• Time in Patent Office: 620 Days
• Field of Search: 600/510
• US Class Current: 1/1
• CPC Class Codes: A61B 5/1118 Determining activity level
• CPC Class Codes: A61B 5/363 Detecting tachycardia or bradycardia
• CPC Class Codes: A61B 5/686 Permanently implanted devices, e.g. pacemakers, other stimulators, biochips A61B5/6861 takes precedence
• CPC Class Codes: A61N 1/0587 Epicardial electrode systems; Endocardial electrodes piercing the pericardium
• CPC Class Codes: A61N 1/3622 comprising two or more electrodes co-operating with different heart regions
• CPC Class Codes: A61N 1/371 Capture, i.e. successful stimulation
• CPC Class Codes: A61N 1/37205 Microstimulators, e.g. implantable through a cannula
• CPC Class Codes: A61N 1/3756 Casings with electrodes thereon, e.g. leadless stimulators
• CPC Class Codes: A61N 1/3937 Monitoring output parameters

Abstract

Techniques for determining paced cardiac depolarization waveform morphological templates are described. For example, an implantable medical device (IMD) may sense a cardiac electrogram of a heart, identify cardiac depolarizations within the cardiac electrogram, and determine that the cardiac depolarizations are paced cardiac depolarizations resulting from delivery of a pacing pulse to the heart by another IMD without detecting the pacing pulse and without communicating with the other IMD. The IMD may identify paced cardiac depolarization waveforms of the paced cardiac depolarizations, determine a paced cardiac depolarization waveform morphological template based on the identified paced cardiac depolarization waveforms, determine a normal cardiac depolarization waveform morphological template based on the paced cardiac depolarization waveform morphological template, and compare the normal cardiac depolarization waveform morphological template to subsequent cardiac depolarization waveforms. The IMD may detect a cardiac tachyarrhythmia based on the above comparison.

Claims

1. A method comprising:

sensing, by an implantable medical device, a cardiac electrogram of a heart of a patient;

identifying, by the implantable medical device, a plurality of cardiac depolarizations within the cardiac electrogram;

determining, by the implantable medical device, that one or more of the cardiac depolarizations are paced cardiac depolarizations resulting from delivery of a pacing pulse to the heart by another implantable medical device without detecting the pacing pulse and without communicating with the other implantable medical device;

identifying, by the implantable medical device, one or more paced cardiac depolarization waveforms of the one or more paced cardiac depolarizations;

determining, by the implantable medical device, a paced cardiac depolarization waveform morphological template based on the one or more identified paced cardiac depolarization waveforms;

determining, by the implantable medical device, that the paced cardiac depolarization waveform morphological template is a paced normal cardiac depolarization waveform morphological template;

comparing, by the implantable medical device, the paced normal cardiac depolarization waveform morphological template to subsequent cardiac depolarization waveforms; and

detecting a cardiac tachyarrhythmia based on the comparison of the paced normal cardiac depolarization waveform morphological template to subsequent cardiac depolarization waveforms.

2. The method of claim 1, further comprising:

receiving, by the implantable medical device, an indication of an intrinsic cardiac depolarization of the patient, wherein the intrinsic cardiac depolarization has a faster heart rate than the paced normal cardiac depolarization waveform morphological template;

determining, by the implantable medical device, an intrinsic cardiac depolarization waveform for the intrinsic cardiac depolarization;

comparing, by the implantable medical device, the paced normal cardiac depolarization waveform morphological template to the intrinsic cardiac depolarization waveform; and

verifying, by the implantable medical device, that the paced normal cardiac depolarization waveform morphological template is different than the intrinsic cardiac depolarization waveform.

3. The method of claim 1, further comprising:

identifying, by the implantable medical device, an intrinsic cardiac depolarization waveform based on a comparison of one or more cardiac depolarizations to the paced cardiac depolarization waveform morphological template;

determining, by the implantable medical device, an intrinsic normal cardiac depolarization waveform morphological template based on the intrinsic cardiac depolarization waveform; and

comparing, by the implantable medical device, the intrinsic normal cardiac depolarization waveform morphological template to subsequent cardiac depolarization waveforms,

wherein detecting the cardiac tachyarrhythmia comprises detecting the cardiac tachyarrhythmia based on the comparison of the paced normal cardiac depolarization waveform morphological template and the intrinsic normal cardiac depolarization template to subsequent cardiac depolarization waveforms.

4. The method of claim 1, wherein determining that one or more of the cardiac depolarizations are paced cardiac depolarizations resulting from delivery of the pacing pulse to the heart by the other implantable medical device without detecting the pacing pulse and without communicating with the other implantable medical device comprises:

determining, by the implantable medical device, a heart rate for each of the plurality of cardiac depolarizations;

comparing, by the implantable medical device, the heart rate for each of the plurality of cardiac depolarizations to a rate floor; and

for at least one cardiac depolarization that has a heart rate within a pre-determined range of the rate floor, determining, by the implantable medical device, that the cardiac depolarization is a paced cardiac depolarization resulting from delivery of the pacing pulse to the heart by the other implantable medical device without detecting the pacing pulse and without communicating with the other implantable medical device.

5. The method of claim 4, wherein the rate floor is a modulated rate floor, and wherein the method further comprises:

determining, by the implantable medical device, an activity level of the patient; and

determining, by the implantable medical device and based at least in part on the activity level, the modulated rate floor.

6. The method of claim 1, wherein determining that one or more of the cardiac depolarizations are paced cardiac depolarizations resulting from delivery of the pacing pulse to the heart by the other implantable medical device without detecting the pacing pulse and without communicating with the other implantable medical device comprises:

determining, by the implantable medical device, a heart rate for each of the plurality of cardiac depolarizations;

detecting, by the implantable medical device, a large increase in the heart rate between a first pair of consecutive cardiac depolarizations;

detecting, by the implantable medical device, a plurality of small decreases in the heart rate between a plurality of pairs of consecutive cardiac depolarizations subsequent to the first pair of cardiac depolarizations; and

in response to detecting the plurality of small decreases in the heart rate, determining, by the implantable medical device, that at least one of the cardiac depolarizations in the plurality of pairs of consecutive cardiac depolarizations subsequent to the first pair of cardiac depolarizations is a paced cardiac depolarization resulting from delivery of the pacing pulse to the heart by the other implantable medical device without detecting the pacing pulse and without communicating with the other implantable medical device.

7. The method of claim 1, wherein determining that one or more of the cardiac depolarizations are paced cardiac depolarizations resulting from delivery of the pacing pulse to the heart by the other implantable medical device without detecting the pacing pulse and without communicating with the other implantable medical device comprises:

determining, by the implantable medical device, a heart rate for each of the plurality of cardiac depolarizations;

detecting, by the implantable medical device, a patterned decrease in the heart rate amongst a subset of the plurality of cardiac depolarizations; and

in response to detecting the patterned decrease in the heart rate, determining by the implantable medical device, that at least one of the subset of cardiac depolarizations is a paced cardiac depolarization resulting from delivery of the pacing pulse to the heart by the other implantable medical device without detecting the pacing pulse and without communicating with the other implantable medical device.

8. The method of claim 7, wherein detecting the patterned decrease comprises detecting at least one of a smooth rate decrease of the heart rates or a plurality of decreases by a discrete number of the heart rates.

9. The method of claim 1, wherein the cardiac depolarizations comprise ventricular depolarizations, the method further comprising detecting atrial depolarizations, wherein determining that one or more of the cardiac depolarizations are paced cardiac depolarizations resulting from delivery of the pacing pulse to the heart by the other implantable medical device without detecting the pacing pulse and without communicating with the other implantable medical device comprises:

identifying an atrio-ventricular block based on the atrial depolarizations and the ventricular depolarizations; and

in response to identifying the atrio-ventricular block, determining, by the implantable medical device, that at least one of the ventricular depolarizations during the atrio-ventricular block is a paced cardiac depolarization resulting from delivery of the pacing pulse to the heart by the other implantable medical device without detecting the pacing pulse and without communicating with the other implantable medical device.

10. The method of claim 1, wherein determining that one or more of the cardiac depolarizations are paced cardiac depolarizations resulting from delivery of the pacing pulse to the heart by the other implantable medical device without detecting the pacing pulse and without communicating with the other implantable medical device comprises:

determining, by the implantable medical device, a heart rate for each of the plurality of cardiac depolarizations;

detecting, by the implantable medical device, a series of modulations in the heart rate amongst a subset of the plurality of cardiac depolarizations, wherein the series of modulations comprises an increase by a specific number of beats per minute followed by a decrease by the same specific number of beats per minute; and

in response to detecting the series of modulations, for at least one cardiac depolarization in the subset of cardiac depolarizations, determining, by the implantable medical device, that the cardiac depolarization is a paced cardiac depolarization resulting from delivery of the pacing pulse to the heart by the other implantable medical device without detecting the pacing pulse and without communicating with the other implantable medical device.

11. The method of claim 1, wherein determining that one or more of the cardiac depolarizations are paced cardiac depolarizations resulting from delivery of the pacing pulse to the heart by the other implantable medical device without detecting the pacing pulse and without communicating with the other implantable medical device comprises:

detecting, by the implantable medical device, a first series of cardiac depolarizations of the plurality of cardiac depolarizations with a first set of beat characteristics;

detecting, by the implantable medical device, a second series of cardiac depolarizations of the plurality of cardiac depolarizations subsequent to the first series of cardiac depolarizations with a second set of beat characteristics different than the first set of beat characteristics;

detecting, by the implantable medical device, a third series of cardiac depolarizations of the plurality of cardiac depolarizations subsequent to the second series of cardiac depolarizations with a third set of beat characteristics that are the same as the first set of beat characteristics; and

determining, by the implantable medical device, that the first series of cardiac depolarizations and the third series of cardiac depolarizations are paced cardiac depolarizations resulting from delivery of the pacing pulse to the heart by the other implantable medical device without detecting the pacing pulse and without communicating with the other implantable medical device.

12. The method of claim 11, wherein the first set of beat characteristics comprises a sudden change in a ventricular heart rate by a consistent amount over a first portion of the first series of cardiac depolarizations followed by a stabilization to a consistent form over a second portion of the first series of cardiac depolarizations.

13. The method of claim 1, wherein the implantable medical device is a subcutaneous implantable cardioverter defibrillator (subcutaneous ICD) and the other implantable medical device is a leadless pacing device (LPD).

14. An implantable medical device (IMD), the IMD comprising:

a housing configured to be implanted in a patent external to a rib cage of the patient;

one or more electrodes configured to be disposed external to the rib cage;

a sensing module configured to sense a cardiac electrogram of a heart of the patient using the one or more electrodes; and

a tachyarrhythmia detection module configured to;

identify a plurality of cardiac depolarizations within the cardiac electrogram;

determine that one or more of the cardiac depolarizations are paced cardiac depolarizations resulting from delivery of a pacing pulse to the heart by another implantable medical device without detecting the pacing pulse and without communicating with the other implantable medical device;

identify one or more paced cardiac depolarization waveforms of the one or more paced cardiac depolarizations;

determine a paced cardiac depolarization waveform morphological template based on the one or more identified paced cardiac depolarization waveforms;

determine that the paced cardiac depolarization waveform morphological template is a paced normal cardiac depolarization waveform morphological template;

compare the paced normal cardiac depolarization waveform morphological template to subsequent cardiac depolarization waveforms; and

detect a cardiac tachyarrhythmia based on the comparison of the paced normal cardiac depolarization waveform morphological template to subsequent cardiac depolarization waveforms.

15. The IMD of claim 14, wherein the tachyarrhythmia detection module is further configured to:

receive an indication of an intrinsic cardiac depolarization of the patient, wherein the intrinsic cardiac depolarization has a faster heart rate than the paced normal cardiac depolarization waveform morphological template;

determine an intrinsic cardiac depolarization waveform for the intrinsic cardiac depolarization;

compare the paced normal cardiac depolarization waveform morphological template to the intrinsic cardiac depolarization waveform; and

verify that the paced normal cardiac depolarization waveform morphological template is different than the intrinsic cardiac depolarization waveform.

16. The IMD of claim 14, wherein the tachyarrhythmia detection module is further configured to:

identify an intrinsic cardiac depolarization waveform based on a comparison of one or more cardiac depolarizations to the paced cardiac depolarization waveform morphological template;

determine an intrinsic normal cardiac depolarization waveform morphological template based on the intrinsic cardiac depolarization waveform; and

compare the intrinsic normal cardiac depolarization waveform morphological template to subsequent cardiac depolarization waveforms,

wherein detecting the cardiac tachyarrhythmia comprises detecting the cardiac tachyarrhythmia based on the comparison of the paced normal cardiac depolarization waveform morphological template and the intrinsic normal cardiac depolarization template to subsequent cardiac depolarization waveforms.

17. The IMD of claim 14, wherein the tachyarrhythmia detection module being configured to determine that one or more of the cardiac depolarizations are paced cardiac depolarizations resulting from delivery of the pacing pulse to the heart by the other implantable medical device without detecting the pacing pulse and without communicating with the other implantable medical device comprises the tachyarrhythmia detection module being configured to:

determining, by the implantable medical device, a heart rate for each of the plurality of cardiac depolarizations;

comparing, by the implantable medical device, the heart rate for each of the plurality of cardiac depolarizations to a rate floor; and

for at least one cardiac depolarization that has a heart rate within a pre-determined range of the rate floor, determine that the cardiac depolarization is a paced cardiac depolarization resulting from delivery of the pacing pulse to the heart by the other implantable medical device without detecting the pacing pulse and without communicating with the other implantable medical device.

18. The IMD of claim 17, wherein the rate floor is a modulated rate floor, and wherein the tachyarrhythmia detection module is further configured to:

determine an activity level of the patient; and

determine, based at least in part on the activity level, the modulated rate floor.

19. The IMD of claim 14, wherein the tachyarrhythmia detection module being configured to determine that one or more of the cardiac depolarizations are paced cardiac depolarizations resulting from delivery of the pacing pulse to the heart by the other implantable medical device without detecting the pacing pulse and without communicating with the other implantable medical device comprises the tachyarrhythmia detection module being configured to:

determine a heart rate for each of the plurality of cardiac depolarizations;

detect a large increase in the heart rate between a first pair of consecutive cardiac depolarizations;

detect a plurality of small decreases in the heart rate between a plurality of pairs of consecutive cardiac depolarizations subsequent to the first pair of cardiac depolarizations; and

in response to detecting the plurality of small decreases in the heart rate, determine that at least one of the cardiac depolarizations in the plurality of pairs of consecutive cardiac depolarizations subsequent to the first pair of cardiac depolarizations is a paced cardiac depolarization resulting from delivery of the pacing pulse to the heart by the other implantable medical device without detecting the pacing pulse and without communicating with the other implantable medical device.

20. The IMD of claim 14, wherein the tachyarrhythmia detection module being configured to determine that one or more of the cardiac depolarizations are paced cardiac depolarizations resulting from delivery of the pacing pulse to the heart by the other implantable medical device without detecting the pacing pulse and without communicating with the other implantable medical device comprises the tachyarrhythmia detection module being configured to:

determine a heart rate for each of the plurality of cardiac depolarizations;

detect a patterned decrease in the heart rate amongst a subset of the plurality of cardiac depolarizations; and

in response to detecting the patterned decrease in the heart rate, determine that at least one of the subset of cardiac depolarizations is a paced cardiac depolarization resulting from delivery of the pacing pulse to the heart by the other implantable medical device without detecting the pacing pulse and without communicating with the other implantable medical device.

21. The IMD of claim 20, wherein the tachyarrhythmia detection module being configured to detect the patterned decrease comprises the tachyarrhythmia detection module being configured to detect at least one of a smooth rate decrease of the heart rates or a plurality of decreases by a discrete number of the heart rates.

22. The IMD of claim 14, wherein the cardiac depolarizations comprise ventricular depolarizations, wherein the tachyarrhythmia detection module is further configured to detect atrial depolarizations, and wherein the tachyarrhythmia detection module being configured to determine that one or more of the cardiac depolarizations are paced cardiac depolarizations resulting from delivery of the pacing pulse to the heart by the other implantable medical device without detecting the pacing pulse and without communicating with the other implantable medical device comprises the tachyarrhythmia detection module being configured to:

identify an atrio-ventricular block based on the atrial depolarizations and the ventricular depolarizations; and

in response to identifying the atrio-ventricular block, determine that at least one of the ventricular depolarizations during the atrio-ventricular block is a paced cardiac depolarization resulting from delivery of the pacing pulse to the heart by the other implantable medical device without detecting the pacing pulse and without communicating with the other implantable medical device.

23. The IMD of claim 14, wherein the tachyarrhythmia detection module being configured to determine that one or more of the cardiac depolarizations are paced cardiac depolarizations resulting from delivery of the pacing pulse to the heart by the other implantable medical device without detecting the pacing pulse and without communicating with the other implantable medical device comprises the tachyarrhythmia detection module being configured to:

determine a heart rate for each of the plurality of cardiac depolarizations;

detect a series of modulations in the heart rate amongst a subset of the plurality of cardiac depolarizations, wherein the series of modulations comprises an increase by a specific number of beats per minute followed by a decrease by the same specific number of beats per minute; and

in response to detecting the series of modulations, for at least one cardiac depolarization in the subset of cardiac depolarizations, determine that the cardiac depolarization is a paced cardiac depolarization resulting from delivery of the pacing pulse to the heart by the other implantable medical device without detecting the pacing pulse and without communicating with the other implantable medical device.

24. The IMD of claim 14, wherein the tachyarrhythmia detection module being configured to determine that one or more of the cardiac depolarizations are paced cardiac depolarizations resulting from delivery of the pacing pulse to the heart by the other implantable medical device without detecting the pacing pulse and without communicating with the other implantable medical device comprises the tachyarrhythmia detection module being configured to:

detect a first series of cardiac depolarizations of the plurality of cardiac depolarizations with a first set of beat characteristics;

detect a second series of cardiac depolarizations of the plurality of cardiac depolarizations subsequent to the first series of cardiac depolarizations with a second set of beat characteristics different than the first set of beat characteristics;

detect a third series of cardiac depolarizations of the plurality of cardiac depolarizations subsequent to the second series of cardiac depolarizations with a third set of beat characteristics that are the same as the first set of beat characteristics; and

determine that the first series of cardiac depolarizations and the third series of cardiac depolarizations are paced cardiac depolarizations resulting from delivery of the pacing pulse to the heart by the other implantable medical device without detecting the pacing pulse and without communicating with the other implantable medical device.

25. The IMD of claim 24, wherein the first set of beat characteristics comprises a sudden change in a ventricular heart rate by a consistent amount over a first portion of the first series of cardiac depolarizations followed by a stabilization to a consistent form over a second portion of the first series of cardiac depolarizations.

26. The IMD of claim 14, wherein the IMD is a subcutaneous implantable cardioverter defibrillator (subcutaneous ICD).

27. A device comprising:

means for sensing a cardiac electrogram of a heart of a patient;

means for identifying a plurality of cardiac depolarizations within the cardiac electrogram;

means for determining that one or more of the cardiac depolarizations are paced cardiac depolarizations resulting from delivery of a pacing pulse to the heart by another implantable medical device without detecting the pacing pulse and without communicating with the other implantable medical device;

means for identifying one or more paced cardiac depolarization waveforms of the one or more paced cardiac depolarizations;

means for determining a paced cardiac depolarization waveform morphological template based on the one or more identified paced cardiac depolarization waveforms;

means for determining that the paced cardiac depolarization waveform morphological template is a paced normal cardiac depolarization waveform morphological template;

means for comparing the paced normal cardiac depolarization waveform morphological template to subsequent cardiac depolarization waveforms; and

means for detecting a cardiac tachyarrhythmia based on the comparison of the paced normal cardiac depolarization waveform morphological template to subsequent cardiac depolarization waveforms.