Blood sampling tube with integrated sensor device

• US 9,468,404 B2
• Filed: 01/22/2013
• Issued: 10/18/2016
• Est. Priority Date: 02/14/2012
• Status: Active Grant

• Current Assignee: Siemens Healthcare Diagnostics Incorporated (Siemens AG)
• Original Assignee: Siemens AG
• Inventors: Hayden, Oliver
• Primary Examiner(s): Hyun, Paul
• Application Number:
  US14/378,143
• Publication Number:
  US 20150011847A1
• Time in Patent Office: 1,365 Days
• US Class Current: 1/1
• CPC Class Codes: A61B 5/05 Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves impedance plethysmography A61B5/0295; measuring movement of the entire body or parts thereof A61B5/11; detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof A61B5/24
• CPC Class Codes: A61B 5/145 Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissuemeasuring of blood pressure or blood flow A61B5/02; non-radiation detecting or locating of foreign bodies in blood A61B5/06
• CPC Class Codes: A61B 5/1455 using optical sensors, e.g. spectral photometrical oximeters
• CPC Class Codes: A61B 5/15003 for venous or arterial blood
• CPC Class Codes: A61B 5/150099 by negative pressure, other than vacuum extraction into a syringe by pulling on the piston rod or into pre-evacuated tubes
• CPC Class Codes: A61B 5/150221 Valves
• CPC Class Codes: A61B 5/150251 Collection chamber divided into at least two compartments, e.g. for division of samples injection syringes having more than one chamber A61M5/19; syringes for injection of two or more media A61M5/2448, A61M5/284; sample preparation for further analysis A61B5/150755
• CPC Class Codes: A61B 5/150389 Hollow piercing elements, e.g. canulas, needles, for piercing the skin
• CPC Class Codes: A61B 5/150503 Single-ended needles hollow piercing element tip design A61B5/150396, needle sets for catheters A61M25/06, needles for bringing media into the body A61M5/32
• CPC Class Codes: A61B 5/150732 Needle holders, for instance for holding the needle by the hub, used for example with double-ended needle and pre-evacuated tube,
• CPC Class Codes: A61B 5/150755 Blood sample preparation for further analysis, e.g. by separating blood components or by mixing
• CPC Class Codes: A61B 5/150854 long distance, e.g. between patient's home and doctor's office
• CPC Class Codes: A61B 5/150862 intermediate range, e.g. within room or building
• CPC Class Codes: A61B 5/15087 short range, e.g. between console and disposable using implanted devices A61B5/150877
• CPC Class Codes: A61B 5/150923 by means for destroying components or parts, e.g. by cutting or piercing
• CPC Class Codes: A61B 5/150946 Means for varying, regulating, indicating or limiting the speed or time of blood collection
• CPC Class Codes: A61B 5/153 Devices specially adapted for taking samples of venous or arterial blood, e.g. with syringes
• CPC Class Codes: A61B 5/154 Devices using pre-evacuated means
• CPC Class Codes: A61B 5/157 Devices characterised by integrated means for measuring characteristics of blood

Abstract

A blood-sampling tube with a first fluid-receiving chamber for receiving a fluid is described, where the first fluid-receiving chamber may be connected to at least one fluid channel that has a sensor device for measuring at least one biochemical function of the fluid passed through the fluid channel, where the measured biochemical function of the fluid may be read out from the sensor device via a data interface of the blood-sampling tube.

Claims

1. A blood sampling tube comprising:

a first fluid receiving chamber for receiving a fluid, wherein the first fluid receiving chamber is connected to at least one fluid channel comprising a sensor device for measuring at least one biochemical function of the fluid passed through the at least one fluid channel,

wherein the at least one measured biochemical function of the fluid is configured to be read out from the sensor device via a data interface of the blood sampling tube,

wherein the sensor device is configured to measure the at least one biochemical function of the fluid contactlessly, and

wherein the sensor device comprises at least one magnetoelastic capillary tube through which the fluid to be examined is passed.

2. The blood sampling tube as claimed in claim 1 futher comprising a second fluid receiving chamber, wherein the fluid is passed through the fluid channel to the second fluid receiving chamber by negative pressure.

3. The blood sampling tube as claimed in claim 2, wherein the first fluid receiving chamber and the second fluid receiving chamber are separated from the at least one fluid channel by rupture disks or by valves.

4. The blood sampling tube as claimed claim 2, wherein an incubation device for adding reagents to the fluid passed through the at least one fluid channel is provided in the at least one fluid channel.

5. The blood sampling tube as claimed in claim 4, wherein the at least one fluid channel has a predetermined fluid channel volume between the incubation device and the sensor device, wherein the predetermined fluid channel volume and a flow velocity of the fluid passed through the at least one fluid channel determine an adjustable reaction time of the reagents, dispensed by the incubation device, with the fluid.

6. The blood sampling tube as claimed in claim 5, wherein the flow velocity of the fluid passed through the at least one fluid channel depends upon an adjustable pressure drop between the first fluid receiving chamber and the second fluid receiving chamber of the blood sampling tube.

7. The blood sampling tube as claimed in claim 1, further comprising a needle placed onto the blood sampling tube and configured to withdraw a bodily fluid from an organism.

8. The blood sampling tube as claimed in claim 7, wherein the bodily fluid is venous blood or urine.

9. The blood sampling tube as claimed claim 1, wherein an incubation device is provided in the at least one fluid channel for adding reagents to the fluid passed through the fluid channel.

10. The blood sampling tube as claimed in claim 9, wherein the at least one fluid channel has a predetermined fluid channel volume between the incubation device and the sensor device, wherein the predetermined fluid channel volume and a flow velocity of the fluid passed through the at least one fluid channel determine an adjustable reaction time of the reagents, dispensed by the incubation device, with the fluid.

11. The blood sampling tube as claimed in claim 10, wherein the flow velocity of the fluid passed through the at least one fluid channel depends upon an adjustable pressure drop between the first fluid receiving chamber and a second fluid receiving chamber of the blood sampling tube. depends on a surface load on an inner wall of the at least one magnetoelastic capillary tube, is configured to be read out contactlessly for determining the at least one biochemical function of the fluid.

12. The blood sampling tube as claimed in claim 1, wherein a resonant frequency of the at least one magnetoelastic capillary tube, which depends on a surface load on an inner wall of the at least one magnetoelastic capillary tube, is configured to be read out contactlessly for determining the at least one biochemical function of the fluid.

13. The blood sampling tube as claimed in claim 1, wherein the sensor device establishes the at least one biochemical function of the fluid by an optical transmission or stray light measurement.

14. The blood sampling tube as claimed in claim 1, wherein the data interface of the blood sampling tube comprises a wireless or wired data interface or a removable data memory card, wherein the card is removable from the blood sampling tube.

15. The blood sampling tube as claimed in claim 1, wherein the data interface of the blood sampling tube transmits the at least one measured biochemical function of the fluid to an external readout instrument.

16. The blood sampling tube as claimed in claim 15, wherein the external readout instrument connected to the data interface is a mobile hand-held device.

17. The blood sampling tube as claimed in claim 16, wherein the mobile hand-held device is a mobile communications device.

18. The blood sampling tube as claimed in claim 1, wherein the blood sampling tube is a disposable product.