Pain management with stimulation subthreshold to paresthesia

• US 9,468,762 B2
• Filed: 02/05/2015
• Issued: 10/18/2016
• Est. Priority Date: 03/24/2009
• Status: Active Grant

• Current Assignee: TC1 LLC (Abbott Laboratories Incorporated)
• Original Assignee: St. Jude Medical Luxembourg Holdings SMI S.A.R.L.
• Inventors: Kishawi, Eyad, Kramer, Jeffery M.
• Primary Examiner(s): GETZOW, SCOTT M
• Application Number:
  US14/615,281
• Publication Number:
  US 20150151126A1
• Time in Patent Office: 621 Days
• US Class Current: 1/1
• CPC Class Codes: A61N 1/0551 Spinal or peripheral nerve electrodes
• CPC Class Codes: A61N 1/36017 with leads or electrodes penetrating the skin
• CPC Class Codes: A61N 1/36021 for treatment of pain
• CPC Class Codes: A61N 1/36071 Pain
• CPC Class Codes: A61N 1/36157 Current A61N1/3616 takes precedence

Abstract

Devices, systems and methods are provided for treating pain while minimizing or eliminating possible complications and undesired side effects, particularly the sensation of paresthesia. This is achieved by stimulating in proximity to a dorsal root ganglion with stimulation energy in a manner that will affect pain sensations without generating substantial sensations of paresthesia. In some embodiments, such neurostimulation takes advantage of anatomical features and functions particular to the dorsal root ganglion.

Claims

1. A method of modulating a dorsal root ganglion of a patient comprising:

advancing an electrode along a nerve root sleeve angulation of a dorsal root;

positioning the electrode on or near a dorsal root ganglion associated with the dorsal root;

providing electrical pulses to the electrode using a plurality of different pulse parameters to identify a stimulation program of multiple stimulation parameters that cause analgesia without resultant paresthesia, wherein the providing comprises selecting a pulse frequency less than 25 Hz, a pulse amplitude of less than 500 microamps, and a pulse width of less than 120 microseconds; and

activating a pulse generator to provide electrical pulses to the patient using the electrode according to the identified stimulation program of multiple stimulation parameters to treat pain of the patient with analgesia and without resultant paresthesia.

2. The method of claim 1 wherein the providing comprises varying pulse frequency between 2 Hz and 25 Hz.

3. The method of claim 1 wherein the providing comprises varying multiple stimulation parameters to achieve dermatome specific pain relief.

4. The method of claim 1, wherein the activating a pulse generator comprises providing stimulation pulses below a threshold for Aβ

fiber recruitment.

5. The method of claim 4, wherein the activating a pulse generator comprises providing stimulation pulses below a threshold for Aβ

fiber cell body recruitment.

6. The method of claim 5, wherein the activating a pulse generator comprises providing stimulation pulses above a threshold for C fiber cell body modulation.

7. The method of claim 5, wherein the activating a pulse generator comprises providing stimulation pulses above a threshold for small myelinated fiber cell body modulation.

8. The method of claim 5, wherein the activating a pulse generator comprises providing stimulation pulses above a threshold for unmyelinated fiber cell body modulation.