Methods for the acylation of maytansinol
First Claim
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1. A method of preparing a compound represented by the following formula:
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Abstract
Disclosed is a method of preparing an amino acid ester of maytansinol by reacting maytansinol with an N-carboxyanhydride of an amino acid (NCA) in the presence of a drying agent. Also disclosed is an improved method of preparing an amino acid ester of maytansinol in which a nucleophile is added to the reaction mixture after completion of the reaction between maytansinol and an N-carboxyanhydride of an amino acid.
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22 Claims
- 1. A method of preparing a compound represented by the following formula:
- 6. A method of preparing a compound represented by the following formula:
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