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Method and system for quantifying anaesthesia or a state of vigilance

  • US 9,474,452 B2
  • Filed: 05/21/2012
  • Issued: 10/25/2016
  • Est. Priority Date: 06/17/2011
  • Status: Expired due to Fees
First Claim
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1. A method for quantifying at least one of anaesthesia and a state of vigilance from a plurality of parameters acquired from a subject, said method comprising the steps of:

  • acquiring a plurality of p parameters pertaining to said subject, said parameters being selected from a first parameter group comprising electrocardiogram data acquired from said subject, a heart rate, a heart rate variability, a blood pressure, a blood pressure variability, a breathing gas composition, a pharmacokinetic/pharmacodynamic modelled effect site concentration and/or plasma concentration, and/or a second parameter group comprising electroencephalogram data and/or auditory evoked potential data acquired from said subject, and/or a third parameter group comprising subject data and/or medication data;

    wherein p≧

    2, and at least one of said p parameters is selected from said first parameter group or said second parameter group;

    wherein said parameters of at least one of said first parameter group and said second parameter group are acquired continuously or at predetermined time intervals by monitoring said subject; and

    determining an indicator that performs at least one of quantifying a depth of anaesthesia, detecting intraoperative awareness and quantifying an analgesic component of anaesthesia or a state of vigilance of said subject from said p parameters;

    wherein said step of determining said indicator comprises a step of combining said p parameters, wherein said number p of parameters is variable while monitoring said subject;

    wherein said step of determining said indicator comprises the steps of;

    determining a first sub-indicator based on a first subset of parameters chosen among said p parameters and/or based on a comparison with a first training set of data, wherein said first sub-indicator is adapted to characterize a first aspect of an anaesthesia or vigilance state of said subject;

    determining a second sub-indicator based on at least one of a second subset of parameters chosen among said p parameters and a comparison with a second training set of data, said second subset of parameters being different from said first subset of parameters and/or said second training set of data being different from said first training set of data, wherein said second sub-indicator is adapted to characterize a second aspect of an anaesthesia or vigilance state of said subject; and

    combining said first sub-indicator and said second sub-indicator to compute said indicator.

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