Method and system for quantifying anaesthesia or a state of vigilance
First Claim
1. A method for quantifying at least one of anaesthesia and a state of vigilance from a plurality of parameters acquired from a subject, said method comprising the steps of:
- acquiring a plurality of p parameters pertaining to said subject, said parameters being selected from a first parameter group comprising electrocardiogram data acquired from said subject, a heart rate, a heart rate variability, a blood pressure, a blood pressure variability, a breathing gas composition, a pharmacokinetic/pharmacodynamic modelled effect site concentration and/or plasma concentration, and/or a second parameter group comprising electroencephalogram data and/or auditory evoked potential data acquired from said subject, and/or a third parameter group comprising subject data and/or medication data;
wherein p≧
2, and at least one of said p parameters is selected from said first parameter group or said second parameter group;
wherein said parameters of at least one of said first parameter group and said second parameter group are acquired continuously or at predetermined time intervals by monitoring said subject; and
determining an indicator that performs at least one of quantifying a depth of anaesthesia, detecting intraoperative awareness and quantifying an analgesic component of anaesthesia or a state of vigilance of said subject from said p parameters;
wherein said step of determining said indicator comprises a step of combining said p parameters, wherein said number p of parameters is variable while monitoring said subject;
wherein said step of determining said indicator comprises the steps of;
determining a first sub-indicator based on a first subset of parameters chosen among said p parameters and/or based on a comparison with a first training set of data, wherein said first sub-indicator is adapted to characterize a first aspect of an anaesthesia or vigilance state of said subject;
determining a second sub-indicator based on at least one of a second subset of parameters chosen among said p parameters and a comparison with a second training set of data, said second subset of parameters being different from said first subset of parameters and/or said second training set of data being different from said first training set of data, wherein said second sub-indicator is adapted to characterize a second aspect of an anaesthesia or vigilance state of said subject; and
combining said first sub-indicator and said second sub-indicator to compute said indicator.
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Abstract
A method and a system for quantifying anaesthesia and/or a state of vigilance (e.g. monitoring sedation or sleep) from a plurality of parameters acquired from a subject allows to determine an indicator that reliably quantifies the hypnotic component of anaesthesia and/or the state of vigilance and/or the analgesic component of anaesthesia, even if the number of parameters varies while monitoring the subject. Preferably, a first sub-indicator based on a first subset of parameters adapted to characterize a boundary region between consciousness and unconsciousness is determined, and a second sub-indicator based on a second subset of parameters adapted to characterize a level of hypnosis of said subject is determined, and said first sub-indicator and said second sub-indicator are then combined to compute a global indicator value.
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Citations
15 Claims
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1. A method for quantifying at least one of anaesthesia and a state of vigilance from a plurality of parameters acquired from a subject, said method comprising the steps of:
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acquiring a plurality of p parameters pertaining to said subject, said parameters being selected from a first parameter group comprising electrocardiogram data acquired from said subject, a heart rate, a heart rate variability, a blood pressure, a blood pressure variability, a breathing gas composition, a pharmacokinetic/pharmacodynamic modelled effect site concentration and/or plasma concentration, and/or a second parameter group comprising electroencephalogram data and/or auditory evoked potential data acquired from said subject, and/or a third parameter group comprising subject data and/or medication data; wherein p≧
2, and at least one of said p parameters is selected from said first parameter group or said second parameter group;wherein said parameters of at least one of said first parameter group and said second parameter group are acquired continuously or at predetermined time intervals by monitoring said subject; and determining an indicator that performs at least one of quantifying a depth of anaesthesia, detecting intraoperative awareness and quantifying an analgesic component of anaesthesia or a state of vigilance of said subject from said p parameters; wherein said step of determining said indicator comprises a step of combining said p parameters, wherein said number p of parameters is variable while monitoring said subject; wherein said step of determining said indicator comprises the steps of; determining a first sub-indicator based on a first subset of parameters chosen among said p parameters and/or based on a comparison with a first training set of data, wherein said first sub-indicator is adapted to characterize a first aspect of an anaesthesia or vigilance state of said subject; determining a second sub-indicator based on at least one of a second subset of parameters chosen among said p parameters and a comparison with a second training set of data, said second subset of parameters being different from said first subset of parameters and/or said second training set of data being different from said first training set of data, wherein said second sub-indicator is adapted to characterize a second aspect of an anaesthesia or vigilance state of said subject; and combining said first sub-indicator and said second sub-indicator to compute said indicator. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. A system for quantifying at least one of anaesthesia and a state of vigilance from a plurality of parameters acquired from a subject, said system comprising:
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acquisition means adapted to acquire a plurality of p parameters pertaining to said subject, said parameters being selected from at least one of a first parameter group, a second parameter group, and a third parameter group, wherein said first parameter group comprises at least one of electrocardiogram data acquired from said subject, a heart rate, a heart rate variability, a blood pressure, a blood pressure variability, a breathing gas composition, a pharmacokinetic/pharmacodynamic modelled effect site concentration and plasma concentration, wherein said second parameter group comprises at least one of electroencephalogram data and auditory evoked potential data acquired from said subject, and wherein said a third parameter group comprises at least one of subject data and medication data; wherein p≧
2, and at least one of said p parameters is selected from said first parameter group or said second parameter group;wherein said acquisition means are adapted to acquire said parameters of at least one of said first parameter group and said second parameter group continuously or at predetermined time intervals; and calculation means adapted to determine from said p parameters an indicator that quantifies a depth of anaesthesia and/or detects intraoperative awareness and/or quantifies an analgesic component of anaesthesia or a state of vigilance of said subject; characterized in that said acquisition means are adapted to acquire a number p of parameters that varies while monitoring said subject, and said calculation means are adapted to determine said indicator by combining said number p of parameters that varies while monitoring said subject; wherein said calculations means are adapted to; determine a first sub-indicator based on a first subset of parameters chosen among said p parameters and/or based on a comparison with a first training set of data, wherein said first sub-indicator is adapted to characterize a first aspect of an anaesthesia or vigilance state of said subject; determine a second sub-indicator based on at least one of a second subset of parameters chosen among said p parameters and a comparison with a second training set of data, said second subset of parameters being different from said first subset of parameters and/or said second training set of data being different from said first training set of data, wherein said second sub-indicator is adapted to characterize a second aspect of an anaesthesia or vigilance state of said subject; and combine said first sub-indicator and said second sub-indicator to compute said indicator. - View Dependent Claims (13, 14)
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15. A method for quantifying at least one of anaesthesia and a state of vigilance from a plurality of parameters acquired from a subject, said method comprising the steps of:
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acquiring a plurality of p parameters pertaining to said subject, said parameters being selected from a first parameter group comprising electrocardiogram data acquired from said subject, a heart rate, a heart rate variability, a blood pressure, a blood pressure variability, a breathing gas composition, a pharmacokinetic/pharmacodynamic modelled effect site concentration and/or plasma concentration, and/or a second parameter group comprising electroencephalogram data and/or auditory evoked potential data acquired from said subject, and/or a third parameter group comprising subject data and/or medication data; wherein p≧
2, and at least one of said p parameters is selected from said first parameter group or said second parameter group;wherein said parameters of at least one of said first parameter group and said second parameter group are acquired continuously or at predetermined time intervals by monitoring said subject; and determining an indicator that performs at least one of quantifying a depth of anaesthesia, detecting intraoperative awareness and quantifying an analgesic component of anaesthesia or a state of vigilance of said subject from said p parameters; wherein said step of determining said indicator comprises a step of combining said p parameters, wherein said number p of parameters is variable while monitoring said subject; and wherein said step of combining said p parameters comprises the step of employing one or more of an adaptive neuro fuzzy inference system, a neural network, regression, support vector machines and statistical relational machine learning.
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Specification