Magnetic resonance imaging apparatus and magnetic resonance imaging method

• US 9,474,455 B2
• Filed: 04/20/2010
• Issued: 10/25/2016
• Est. Priority Date: 09/18/2009
• Status: Active Grant

• Current Assignee: Toshiba Medical Systems Corporation (Canon Inc.)
• Original Assignee: Toshiba Medical Systems Corporation (Canon Inc.)
• Inventors: Miyazaki, Mitsue, Kuhara, Shigehide
• Primary Examiner(s): TURCHEN, ROCHELLE DEANNA
• Application Number:
  US12/763,643
• Publication Number:
  US 20110071382A1
• Time in Patent Office: 2,380 Days
• Field of Search: 600/410, 600/413, 600/419
• US Class Current: 1/1
• CPC Class Codes: A61B 5/0037 Performing a preliminary scan, e.g. a prescan for identifying a region of interest
• CPC Class Codes: A61B 5/0263 using NMR
• CPC Class Codes: A61B 5/029 Measuring or recording blood output from the heart, e.g. minute volume A61B8/065 takes precedence
• CPC Class Codes: A61B 5/318 Heart-related electrical modalities, e.g. electrocardiography [ECG]
• CPC Class Codes: A61B 5/7271 Specific aspects of physiological measurement analysis A61B5/316, A61B5/349 and A61B5/374 take precedence
• CPC Class Codes: A61B 5/742 using visual displays A61B5/339 takes precedence
• CPC Class Codes: G01R 33/385 using gradient magnetic field coils
• CPC Class Codes: G01R 33/4833 using spatially selective excitation of the volume of interest, e.g. selecting non-orthogonal or inclined slices
• CPC Class Codes: G01R 33/543 Control of the operation of the MR system, e.g. setting of acquisition parameters prior to or during MR data acquisition, dynamic shimming, use of one or more scout images for scan plane prescription G01R33/546 takes precedence
• CPC Class Codes: G01R 33/5601 involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent
• CPC Class Codes: G01R 33/5608 Data processing and visualization specially adapted for MR, e.g. for feature analysis and pattern recognition on the basis of measured MR data, segmentation of measured MR data, edge contour detection on the basis of measured MR data, for enhancing measured MR data in terms of signal-to-noise ratio by means of noise filtering or apodization, for enhancing measured MR data in terms of resolution by means for deblurring, windowing, zero filling, or generation of gray-scaled images, colour-coded images or images displaying vectors instead of pixels image data processing or generation, in general G06T
• CPC Class Codes: G01R 33/5635 Angiography, e.g. contrast-enhanced angiography [CE-MRA] or time-of-flight angiography [TOF-MRA]
• CPC Class Codes: G01R 33/56366 Perfusion imaging

Abstract

According to one of the aspects of an MRI apparatus of the present invention, the MRI apparatus includes an imaging data acquiring unit and a blood flow information generating unit. The imaging data acquiring unit acquires imaging data from an imaging region including myocardium, without using a contrast medium, by applying a spatial selective excitation pulse to a region including at least a part of an ascending aorta for distinguishably displaying inflowing blood flowing into the imaging region. The blood flow information generating unit generates blood flow image data based on the imaging data.

Claims

1. A magnetic resonance imaging (MRI) apparatus comprising:

an assembly of gantry components including static and gradient magnetic field generators and at least one radio frequency (RF) coil; and

an MRI control system, connected to control said gantry components, including at least one RF transmitter, at least one RF receiver and one or more computer control circuits, the MRI control system being configured to;

acquire a plurality of MR images from an imaging region including a coronary artery providing a myocardium with blood without using a contrast medium, by applying a spatially selective RF excitation pulse to a region including at least a part of an ascending aorta of a heart; and

generate a plurality of blood flow images of the heart based on the acquired plurality of MR images,

wherein the plurality of MR images are acquired while changing, for each of the plurality of MR images, respective traveling times of the inflowing blood between each application of the spatially selective RF excitation pulse and each data acquisition so that a start time of each data acquisition is in the same cardiac time phase regardless of using the different traveling times, by changing a delay time from a synchronization signal to the spatially selective RF excitation pulse.

2. The magnetic resonance imaging apparatus according to claim 1, wherein the MRI control system is further

configured to apply a spatially selective RF excitation pulse plural times, and to acquire the plurality of MR images in 3-dimensional form, each corresponding to a mutually different traveling time of the inflowing blood, in synchronization with a heartbeat by changing a time interval from application timing of the spatially selective RF excitation pulses to acquisition timing of imaging data for the plurality of MR images;

and

generate the plurality of blood flow images, each corresponding to a mutually different traveling time, based on the plurality of MR images.

3. The magnetic resonance imaging apparatus according to claim 2, wherein the MRI control system is further

configured to acquire imaging data for said the plurality of MR images during diastole of an imaged patient heart.

4. The magnetic resonance imaging apparatus according to claim 2, wherein the MRI control system is further

configured to automatically set at least one delay time in electrocardiogram synchronization for acquisition of plural sets of MR imaging data to be acquired in an arbitrary cardiac phase, and to acquire the plural sets of MR imaging data by using the at least one automatically set delay time.

5. The magnetic resonance imaging apparatus according to claim 4, wherein the MRI control system is further

configured to use a specified pulse sequence for acquiring imaging data corresponding to traveling time of the inflowing blood and a specified time parameter used to determine a pulse sequence, in order to automatically set a delay time from a reference wave of an electrocardiogram signal in a pulse sequence for acquiring imaging data corresponding to traveling time of the inflowing blood.

6. The magnetic resonance imaging apparatus according to claim 2, wherein the MRI control system is further

configured to apply a labeling pulse as the spatially selective RF excitation pulse.

7. The magnetic resonance imaging apparatus according to claim 2, wherein the MRI control system is further

configured to acquire the plurality of MR images by changing Black Blood Traveling Time of a spatially selective inversion recovery pulse of a Time Spatial Labeling Inversion Pulse method used as the spatially selective RF excitation pulse.

8. The magnetic resonance imaging apparatus according to claim 7, wherein the MRI control system is further

configured to set the Black Blood Traveling Time long enough to extend over plural heartbeats during data acquisition for at least one of the plurality of MR images.

9. The magnetic resonance imaging apparatus according to claim 2, wherein the MRI control system is further

configured to apply a saturation pulse as the spatially selective RF excitation pulse.

10. The magnetic resonance imaging apparatus according to claim 2, wherein the MRI control system is further

configured to apply a labeling pulse as the spatially selective RF excitation pulse to a region different from the imaging region, and to acquire imaging data for the plurality of MR images for distinguishably displaying blood labeled by the labeling pulse.

11. The magnetic resonance imaging apparatus according to claim 10, wherein the MRI control system is further

configured to apply the labeling pulse to a region including a coronary artery.

12. The magnetic resonance imaging apparatus according to claim 10, wherein the MRI control system is further

configured to apply the labeling pulse to a region including only one of a right coronary artery, a left main coronary trunk, a left circumflex artery, and a left anterior descending artery.

13. The magnetic resonance imaging apparatus according to claim 10, wherein the MRI control system is further

configured to apply the labeling pulse to a slab located inside a ventricle.

14. The magnetic resonance imaging apparatus according to claim 10, wherein the MRI control system is further

configured to apply the labeling pulse to a region displayed and set on a scout image indicating a right ventricle, a left ventricle and a left atrium.

15. The magnetic resonance imaging apparatus according to claim 10, wherein the MRI control system is further

configured to apply the labeling pulse to a region determined based on 3-dimensional vessel image data of a coronary artery in a sagittal plane of a heart.

16. The magnetic resonance imaging apparatus according to claim 10, wherein the MRI control system is further

configured to apply a spatially non-selective inversion recovery pulse to the imaging region.

17. The magnetic resonance imaging apparatus according to claim 16, wherein the MRI control system is further

configured to apply an imaging region selective inversion recovery pulse to excite the imaging region selectively after applying the spatially non-selective inversion recovery pulse and the labeling pulse.

18. The magnetic resonance imaging apparatus according to claim 16, wherein the MRI control system is further

configured to set an inversion recovery time after the spatially non-selective inversion recovery pulse for data acquisition timing for the plurality of MR images and a time interval from application of the labeling pulse to the data acquisition for at least one of the plurality of said MR images, changeably and independently of each other.

19. The magnetic resonance imaging apparatus according to claim 18, wherein the MRI control system is further

configured to set the data acquisition timing for the plurality of said MR images to a timing when both an absolute value of longitudinal magnetization of blood except the inflowing blood and an absolute value of longitudinal magnetization of the myocardium become equal to or less than a predetermined value.

20. The magnetic resonance imaging apparatus according to claim 19, wherein the MRI control system is further

configured to inhibit a signal from the blood except the inflowing blood by performing image reconstruction processing using real parts of the imaging data acquired for said plurality of MR images.

21. The magnetic resonance imaging apparatus according to claim 2, wherein the MRI control system is further

configured to acquire the imaging data for the plurality of MR images distinguishably displaying the inflowing blood by applying the spatially selective RF excitation pulse to the imaging region.

22. The magnetic resonance imaging apparatus according to claim 2, wherein the MRI control system is further

configured to acquire imaging data for a second plurality of MR images each corresponding to mutually different traveling times without application of the spatially selective RF excitation pulse, and

to generate the plurality of blood flow images based on difference data between the plurality of MR images acquired with application of the spatially selective RF excitation pulse and the second plurality of MR images acquired without application of the spatially selective RF excitation pulse.

23. The magnetic resonance imaging apparatus according to claim 2, wherein the MRI control system is further

configured to apply another spatially selective RF excitation pulse in a period between (a) the application time of the spatially selective RE excitation pulse and (b) acquisition time of imaging data.

24. The magnetic resonance imaging apparatus according to claim 2, wherein the MRI control system is further configured to:

acquire a plurality of 2-dimensional data sets with application of the spatially selective RF excitation pulse by changing a delay time from (a) an application time of the spatially selective RE excitation pulse to (b) image data acquisition timing, and to display a plurality of cross-sectional images based on the plural 2-dimensional data sets; and

select at least two of the cross-sectional images based on input information, and to set the delay time corresponding to the selected cross-sectional images as a time interval from the application of the spatially selective RF excitation pulse to acquisition of the imaging data for the plurality of MR images.

25. The magnetic resonance imaging apparatus according to claim 2, wherein the MRI control system is further

configured to acquire one or more of the imaging data for the plural MR images by applying at least one of medicational stress and exercise stress to the imaging region.

26. The magnetic resonance imaging apparatus according to claim 2, wherein the MRI control system is further configured to:

acquire imaging data for one or more of the plurality of MR images as a first data set by applying at least one of medicational stress and exercise stress to the imaging region;

acquire imaging data for plural second MR images as a second data set by applying neither medicational stress nor exercise stress to the imaging region; and

generate the plurality of blood flow images based on differences between the first data set and the second data set.

27. The magnetic resonance imaging apparatus according to claim 2, wherein the MRI control system is further

configured to acquire a magnetic resonance signal for measuring motion quantity caused by respiration prior to acquisition of the plurality of imaging data, and to correct disposition of the imaging region according to the measured motion quantity.

28. The magnetic resonance imaging apparatus according to claim 2, wherein the MRI control system is further configured to:

acquire a magnetic resonance signal for measuring motion quantity caused by respiration prior to acquisition of respective ones of the plurality of MR images; and

generate the plurality of blood flow images by performing motion correction using the measured motion quantity.

29. The magnetic resonance imaging apparatus according to claim 2, wherein the MRI control system is further

configured to generate the plurality of blood flow images by performing correction to eliminate a signal component corresponding to a background of an image from the imaging data.

30. The magnetic resonance imaging apparatus according to claim 2, wherein the MRI control system is further

configured to control a time interval from (a) a last reference wave of an electrocardiogram signal before acquisition of the imaging data to (b) the acquisition of the imaging data by estimating a cyclic period of a heartbeat based on the electrocardiogram signal.

32. The magnetic resonance imaging apparatus according to claim 1, wherein the MRI control system is configured to acquire:

the plurality of MR images with application of a spatially non-selective inversion recovery pulse and a spatially selective inversion recovery pulse, and

a plurality of second images with application of a spatially selective inversion pulse without applying a spatially non-selective inversion recovery pulse.

31. A magnetic resonance imaging (MRI) method comprising:

acquiring 3-dimensional MR imaging data sets from an imaging region including a coronary artery providing a myocardium with blood without using a contrast medium, by applying a spatially selective RF excitation pulse plural times to a region including (a) at least a part of an ascending aorta of a heart; and

generating a plurality of blood flow images of the heart based on the acquired MR imaging data,

wherein the plurality of MR imaging data sets are acquired while changing, for each of the plurality of MR imaging data sets, respective traveling times of the inflowing blood between each application of the spatially selective RF excitation pulse and each data acquisition so that a start time of each data acquisition is in the same cardiac time phase regardless of using the different traveling times, by changing a delay time from a synchronization signal to the spatially selective RF excitation pulse.

33. A magnetic resonance imaging apparatus comprising:

an assembly of gantry components including static and gradient magnetic field generators, and at least one radio frequency (RF) coil; and

an MRI control system, connected to control said gantry components, including at least one RF transmitter, at least one RF receiver and one or more computer control circuits, the MRI control system configured to;

acquire a plurality of MR images from an imaging region including a coronary artery providing a myocardium with blood without using a contrast medium, including application of a spatially selective RF excitation pulse to a region including at least a part of an ascending aorta of a heart; and

generate a plurality of blood flow images of the heart based on the acquired plurality of MR images,

wherein the plurality of MR images are acquired while changing, for each of the plurality of MR images, respective traveling times of the inflowing blood between each application of the spatially selective RF excitation pulse and each data acquisition so that a start time of each data acquisition is in the same cardiac time phase regardless of using the different traveling times, by changing a delay time from a synchronization signal to the spatially selective RF excitation pulse.