Method and system for ventilation

• US 9,474,469 B2
• Filed: 10/22/2009
• Issued: 10/25/2016
• Est. Priority Date: 10/24/2008
• Status: Active Grant

• Current Assignee: Hospitech Respiration Ltd
• Original Assignee: Hospitech Respiration Ltd
• Inventors: Deutsch, Israel, Efrati, Shai
• Primary Examiner(s): Yu, Justine
• Assistant Examiner(s): TSAI, MICHAEL JASPER
• Application Number:
  US13/124,663
• Publication Number:
  US 20110197888A1
• Time in Patent Office: 2,560 Days
• Field of Search: 12820714-20716, 604/93.01, 604/96.01, 604/97.01, 604/99.01, 604/99.02, 604/500, 600/529, 600/533, 600/538
• US Class Current: 1/1
• CPC Class Codes: A61B 5/085 Measuring impedance of respiratory organs or lung elasticity
• CPC Class Codes: A61M 16/0051 with alarm devices
• CPC Class Codes: A61M 16/026 specially adapted for predicting, e.g. for determining an information representative of a flow limitation during a ventilation cycle by using a root square technique or a regression analysis
• CPC Class Codes: A61M 16/0434 Cuffs
• CPC Class Codes: A61M 16/044 External cuff pressure control or supply, e.g. synchronisation with respiration
• CPC Class Codes: A61M 16/0463 combined with suction tubes, catheters or the like; Outside connections
• CPC Class Codes: A61M 16/0479 above the cuff, e.g. giving access to the upper trachea
• CPC Class Codes: A61M 16/0484 at the distal end
• CPC Class Codes: A61M 16/0486 Multi-lumen tracheal tubes
• CPC Class Codes: A61M 2016/0027 pressure meter
• CPC Class Codes: A61M 2016/0036 in the breathing tube and used in both inspiratory and expiratory phase
• CPC Class Codes: A61M 2016/0413 with detectors of CO2 in exhaled gases
• CPC Class Codes: A61M 2205/15 Detection of leaks
• CPC Class Codes: A61M 2205/3306 Optical measuring means
• CPC Class Codes: A61M 2205/3317 Electromagnetic, inductive or dielectric measuring means
• CPC Class Codes: A61M 2205/3331 Pressure; Flow
• CPC Class Codes: A61M 2205/3375 Acoustical, e.g. ultrasonic, measuring means
• CPC Class Codes: A61M 2209/02 Equipment for testing the apparatus

Abstract

A method of monitoring tracheal pressure of a subject is disclosed. The subject is ventilated with breathing gas flowing via an endotracheal tube having an inflatable cuff. The method comprises monitoring sealing of the trachea by the cuff using a close loop control, varying a ventilation pressure thereby varying flow level of the breathing gas, monitoring a response pressure within the cuff in response to the variation, and calculating the tracheal pressure using the ventilation pressure variations, the cuff response pressure and the flow level. In some embodiments, an under-pressure is applied for suctioning fluid carrying secretions, synchronously with variations in the tracheal pressure.

Claims

1. A method of monitoring tracheal pressure of a subject, the subject being ventilated with breathing gas flowing via an endotracheal tube having an inflatable cuff, the method comprising:

monitoring sealing of the trachea by controlling a baseline pressure within said cuff using a close loop control, such as to generally minimize said baseline pressure while ensuring said sealing;

applying variation to a ventilation pressure thereby varying a flow level of the breathing gas;

monitoring variation in a peak above said baseline of a pressure pulse within said cuff responsively to said variation of said ventilation pressure;

calculating a ratio between said monitored variation in said peak and said applied ventilation pressure variations;

calculating the tracheal pressure using said calculated ratio; and

suctioning secretions from the endotracheal tube in synchronization with said monitored tracheal pressure.

2. The method of claim 1, wherein said monitoring said sealing of the trachea comprises measuring a level of at least one measure being indicative of leakage of secretion past said cuff to the lungs;

and the method further comprises adjusting inflation of said cuff based on said level of said at least one measure so as to generally minimize leakage of secretion from above said cuff to the lungs, while minimizing pressure associated damages to the trachea.

3. The method of claim 1, further comprising delivering at least one identifiable additive through said endotracheal tube.

4. The method of claim 3, wherein said monitoring said sealing of the trachea comprises monitoring a level of said at least one identifiable additive at a monitoring location in the body of the subject;

and the method further comprises adjusting inflation of said cuff based on said monitoring so as to generally minimize leakage of secretion from above said cuff to the lungs, while minimizing pressure associated damages to the trachea.

5. The method of claim 1, wherein said tracheal pressure is calculated using a derivative of said ventilation pressure with respect to said response pressure.

6. The method of claim 1, wherein said variation is of less than 10 mmHg.

7. A method of monitoring tracheal pressure of a subject, the subject being ventilated with breathing gas flowing via an endotracheal tube having an inflatable cuff, the method comprising:

monitoring sealing of the trachea by controlling a baseline pressure within said cuff using a close loop control, such as to generally minimize said baseline pressure while ensuring said sealing;

applying variation to a ventilation pressure thereby varying a flow level of the breathing gas;

monitoring variation in a peak above said baseline of a pressure pulse within said cuff responsively to said variation of said ventilation pressure;

calculating a ratio between said monitored variation in said peak and said applied ventilation pressure variations;

calculating obstruction level of said endotracheal tube based on said calculated ratio, an effective internal radius of the endotracheal tube based on said obstruction level, and a pressure drop resulting from said effective internal radius;

calculating the tracheal pressure using said pressure drop; and

suctioning secretions from the endotracheal tube in synchronization with said monitored tracheal pressure.

8. The method of claim 7, further comprising measuring muscular contribution to pressure at the esophagus of the subject, wherein said calculation of said tracheal pressure is based on said muscular contribution.

9. The method of claim 7, further comprising, following a sequence of calculations of the tracheal pressure, calculating a direct relationship between the tracheal pressure and said cuff response pressure, and using said direct relationship for estimating the tracheal pressure over a predetermined time-period following said calculation of said direct relationship.

10. The method of claim 9, wherein said direct relationship is a linear relationship.

11. The method of claim 9, wherein said predetermined time-period is equivalent to at least 10 breaths of the subject.

12. The method of claim 7, wherein said obstruction level is estimated using a derivative of said ventilation pressure with respect to said response pressure.

13. A system for calculating tracheal pressure of a subject, the subject being ventilated with breathing gas flowing via an endotracheal tube having an inflatable cuff, the system comprising:

a cuff inflating unit for inflating said cuff;

a controller, for adjusting said inflation of said cuff so as to provide a minimal cuff inflation pressure being sufficient to ensure sealing of the trachea by said cuff, and for applying variation to a ventilation pressure and flow level of the breathing gas;

a pressure sensor for sensing a pressure within said cuff to monitoring variation in a peak above a baseline of a pressure pulse within said cuff responsively to said variation of said ventilation pressure; and

a tracheal pressure calculator for calculating a ratio between said monitored variation in said peak and said applied ventilation pressure variations, and for calculating the tracheal pressure using said calculated ratio.

14. The system of claim 13, further comprising:

a relationship calculator, for receiving a sequence of calculated tracheal pressures and calculating a direct relationship between the tracheal pressure and said cuff response pressure; and

a tracheal pressure estimator for estimating the tracheal pressure using said direct relationship over a predetermined time-period following said calculation of said direct relationship.

15. The system of claim 13, further comprising a suctioning device configured for suctioning secretions from the endotracheal tube, wherein said controller is configured for synchronizing said suctioning according to said monitored tracheal pressure.

16. The system of claim 13, further comprising the endotracheal tube.

17. The system of claim 16, wherein said endotracheal tube comprises a main lumen for carrying said breathing gas, and a suction conduit formed with a plurality of openings facing said main lumen for allowing suctioning of fluids from said main lumen into said suction conduit.

18. The system of claim 17, wherein said plurality of openings are distributed along a portion of said endotracheal tube which overlaps said cuff.

19. The system of claim 17, wherein at least one of said plurality of openings is at a distance of at least 2 cm from a distal end of said endotracheal tube.

20. The system of claim 17, wherein at least one of said plurality of openings is slanted relative to a wall of said main lumen.

21. The system of claim 13, further comprising a ventilator for providing the breathing gas into said endotracheal tube.

22. A method of monitoring tracheal pressure of a subject, the subject being ventilated with breathing gas flowing via an endotracheal tube having an inflatable cuff, the method comprising:

monitoring sealing of the trachea by controlling a baseline pressure within said cuff using a close loop control, such as to generally minimize said baseline pressure while ensuring said sealing;

applying variation to a ventilation pressure thereby varying a flow level of the breathing gas;

monitoring variation in a peak above said baseline of a pressure pulse within said cuff responsively to said variation of said ventilation pressure;

calculating a ratio between said monitored variation in said peak and said applied ventilation pressure variations; and

calculating the tracheal pressure using said calculated ratio;

wherein said monitoring said sealing of the trachea comprises measuring a level of at least one measure being indicative of leakage of secretion past said cuff to the lungs; and

the method further comprises adjusting inflation of said cuff based on said level of said at least one measure so as to generally minimize leakage of secretion from above said cuff to the lungs, while minimizing pressure associated damages to the trachea.

23. A method of monitoring tracheal pressure of a subject, the subject being ventilated with breathing gas flowing via an endotracheal tube having an inflatable cuff, the method comprising:

monitoring sealing of the trachea by controlling a baseline pressure within said cuff using a close loop control, such as to generally minimize said baseline pressure while ensuring said sealing;

applying variation to a ventilation pressure thereby varying a flow level of the breathing gas;

monitoring variation in a peak above said baseline of a pressure pulse within said cuff responsively to said variation of said ventilation pressure;

calculating a ratio between said monitored variation in said peak and said applied ventilation pressure variations;

calculating the tracheal pressure using said calculated ratio; and

delivering at least one identifiable additive through said endotracheal tube.

24. The method of claim 23, wherein said monitoring said sealing of the trachea comprises monitoring a level of said at least one identifiable additive at a monitoring location in the body of the subject;

and the method further comprises adjusting inflation of said cuff based on said monitoring so as to generally minimize leakage of secretion from above said cuff to the lungs, while minimizing pressure associated damages to the trachea.