Automated medical liquid filling system and method

• US 9,474,690 B2
• Filed: 10/20/2014
• Issued: 10/25/2016
• Est. Priority Date: 12/02/2005
• Status: Active Grant

• Current Assignee: Baxter Corporation Englewood (Baxter International Inc.)
• Original Assignee: Baxter Corporation Englewood (Baxter International Inc.)
• Inventors: Ranalletta, Joseph Vincent, Hutchins, Loren Havener, Aumiller, Joshua Nathan
• Primary Examiner(s): ARNETT, NICOLAS ALLEN
• Application Number:
  US14/518,132
• Publication Number:
  US 20150101707A1
• Time in Patent Office: 736 Days
• Field of Search: 141/2, 141/18, 141 25- 27, 141/95, 141/104, 141/318, 604/407
• US Class Current: 1/1
• CPC Class Codes: A61J 1/20 Arrangements for transferring or mixing fluids, e.g. from vial to syringe
• CPC Class Codes: A61J 1/2065 having aligning and guiding means
• CPC Class Codes: A61M 2005/3114 Filling or refilling
• CPC Class Codes: A61M 2207/00 Methods of manufacture, assembly or production
• CPC Class Codes: A61M 2209/045 for filling, e.g. for filling reservoirs
• CPC Class Codes: B65B 3/003 Filling medical containers such as ampoules, vials, syringes or the like

Abstract

A medical liquid filling system and associated methods are provided, the system comprising a disposable and a drive system. The disposable includes a tubular member and a piston slidably disposed within the tubular member for retraction and advancement within at least a first portion of the tubular member. The disposable may include a seal member for sealing the first portion of the tubular member and may be interconnected to the piston for co-movement therewith. The drive system may include a piston drive member selectively interconnectable to the piston for driven advancement and retraction of the piston within the tubular member. The drive system may be interconnected to a controller, which may be operable to automate or semi-automate various filling operations. A user interface may be interconnected to the controller for providing input of various system operation parameters, which may be communicated to the controller to facilitate automated or semi-automated operation of the filling system.

Claims

1. A drive system, interconnectable to a disposable that includes a tubular member and a piston slidably disposed in the tubular member, for automated filling of at least one interconnectable receptacle with a medical liquid, comprising:

a piston drive member interconnectable to a piston of a disposable for driven advancement and retraction of the piston within a tubular member of the disposable;

a drive motor interconnected to the piston drive member for advancement and retraction of the piston drive member, wherein said drive motor includes a drive motor monitor that provides an output signal indicative of a force output of said drive motor;

a position sensor that provides another output signal indicative of sensed degrees of movement of said piston drive member; and

,

a controller for utilizing one of the output signal and the another output signal to determine a primary control parameter for use in controlling the drive motor to maintain a pressure within said tubular member within a predetermined pressure range, and wherein the controller utilizes the other one of the output signal and the another output signal to determine a secondary control parameter and to determine when said secondary control parameter is outside of a predetermined range.

2. A drive system as recited in claim 1, wherein in response to a determination that the secondary control parameter is outside said predetermined range said controller controls the drive motor to decrease a force supplied by the drive motor to the piston drive member.

3. A drive system as recited in claim 1, further comprising:

a user interface, wherein in response to a determination that the secondary control parameter is outside said predetermined range said controller provides an indication to a user at the user interface.

4. A drive system as recited in claim 1, said position sensor further comprising:

a reference member, wherein said position sensor senses degrees of relative movement between said piston drive member and the reference member and provides said another output signal in relation thereto.

5. A drive system as recited in claim 1, wherein said drive motor comprises:

a moveable output member and, interconnectable to the piston drive member;

a magnetic field member for inducing movement of the moveable output member;

wherein said drive motor monitor comprises a sensor for sensing the position of the moveable output member in relation to the magnetic field member, and for providing said output signal in relation thereto, wherein said controller utilizes said output signal to determine a motor force as the primary control parameter.

6. A drive system as recited in claim 5, wherein said controller utilizes said another output signal to determine a movement rate value as the secondary control parameter.

7. A drive system as recited in claim 1, wherein said controller utilizes said primary control parameter to generate a control signal to operate said drive motor to maintain said pressure within said tubular member within said predetermined pressure range.

8. A drive system as recited in claim 7, wherein said drive motor comprises:

a moveable output member interconnectable to the piston drive member; and

,

a magnetic field member for inducing movement of the moveable output member;

wherein said drive motor monitor comprises a sensor for sensing the position of the moveable output member in relation to the magnetic field member, and for providing said output signal in relation thereto, wherein said controller utilizes said output signal to determine a motor force as the primary control parameter.

9. A drive system as recited in claim 8, wherein said controller utilizes said motor force and a predetermined cross-sectional area of said tubular member of said disposable to generate said control signal to operate said drive motor to maintain a pressure within said tubular member within said predetermined pressure range.

10. A drive system as recited in claim 9, further comprising:

a user interface employable by user to establish said predetermined cross-sectional area for use by said controller.

11. A drive system as recited in claim 7, wherein said position sensor further comprises:

a reference member, wherein said position sensor senses degrees of relative movement between said piston drive member and the reference member and provides said another output signal in relation thereto.

12. A drive system as recited in claim 7, wherein said position sensor comprises:

a rotary encoder.

13. A drive system as recited in claim 7, wherein said controller utilizes said another output signal and a predetermined viscosity of a medical liquid flowed in to and out of said tubular member of said disposable to determine a motor force.

14. A drive system as recited in claim 13, further comprising:

a user interface employable by user to establish said predetermined viscosity of said medical fluid.

15. A drive system as recited in claim 1, wherein said predetermined pressure range includes a predetermined minimum pressure to be maintained during retraction of said piston within said tubular member by said piston drive member to flow a medical liquid in to the tubular member.

16. A drive system as recited in claim 1, wherein said predetermined pressure range further includes a predetermined maximum pressure to be maintained during advancement of said piston within said tubular member by said piston drive member to flow a medical liquid out of the tubular member.

17. A drive system as recited in claim 16, wherein said predetermined pressure range includes a predetermined minimum pressure to be maintained during retraction of said piston within said tubular member by said piston drive member to flow the medical liquid in to the tubular member.

18. A drive system as recited in claim 1, wherein said controller uses said another output signal and a known diameter of the tubular member to control the drive motor to obtain a desired fill volume of a medical liquid in to the tubular member during retraction of the piston in the tubular member.

19. A drive system as recited in claim 18, wherein said controller utilizes said another output signal to determine a movement rate value for use with said known diameter control the drive motor to obtain said desired fill volume.

20. A drive system as recited in claim 1, wherein said controller utilizes said another output signal to determine a movement rate value, and wherein the controller utilizes the movement rate value to control the drive motor to obtain a flow rate of a medical liquid in to the tubular member within a first rate range during retraction of the piston in the tubular member, and to obtain a flow rate of the medical liquid out of the tubular member within a second rate range during advancement of the piston in the tubular member, wherein the first rate range and second rate range are at least partially non-overlapping.