Methods compositions, and kit for whitening hyper pigmented spots on skin

• US 9,474,705 B2
• Filed: 06/18/2014
• Issued: 10/25/2016
• Est. Priority Date: 06/19/2013
• Status: Active Grant

• Current Assignee: ELC Management LLC (The Estee Lauder Companies Inc.)
• Original Assignee: ELC Management LLC (The Estee Lauder Companies Inc.)
• Inventors: Mu, Weilin, Castro, John R.
• Primary Examiner(s): FISHER, ABIGAIL L
• Application Number:
  US14/308,406
• Publication Number:
  US 20140377198A1
• Time in Patent Office: 860 Days
• Field of Search: None
• US Class Current: 1/1
• CPC Class Codes: A61K 2800/43 Pigments; Dyes
• CPC Class Codes: A61K 2800/74 Biological properties of particular ingredients
• CPC Class Codes: A61K 2800/87 Application Devices; Containers; Packaging
• CPC Class Codes: A61K 2800/95 Involves in-situ formation or cross-linking of polymers
• CPC Class Codes: A61K 8/19 containing inorganic ingredients
• CPC Class Codes: A61K 8/25 Silicon; Compounds thereof
• CPC Class Codes: A61K 8/29 Titanium; Compounds thereof
• CPC Class Codes: A61K 8/585 Organosilicon compounds
• CPC Class Codes: A61K 8/8147 Homopolymers or copolymers of acids; Metal or ammonium salts thereof, e.g. crotonic acid, (meth)acrylic acid; Compositions of derivatives of such polymers
• CPC Class Codes: A61K 8/8152 Homopolymers or copolymers of esters, e.g. (meth)acrylic acid esters; Compositions of derivatives of such polymers
• CPC Class Codes: A61K 8/891 saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
• CPC Class Codes: A61P 17/16 Emollients or protectives, e.g. against radiation
• CPC Class Codes: A61Q 19/02 for chemically bleaching or whitening the skin

Abstract

A skin whitening composition comprising a liquid polymeric coating material that, upon exposure to ambient air and moisture in skin, hardens to a water resistant, water vapor permeable, adherent and conformable solid film when applied to skin, and at least one skin whitening active; and a method and kit for whitening skin.

Claims

1. A method for whitening discrete hyper pigmented spots on skin by applying to the discrete spots in need of whitening and not to the surrounding non-hyper-pigmented skin a liquid pigmented treatment composition comprising at least one skin whitening active in a polymeric coating material comprising 1-35% dimethicone silylate;

from 1-50% of a volatile solvent selected from the group consisting of isododecane, dimethicone and mixtures thereof;

from 1-50% of a non-volatile silicone oil having a viscosity of 20 to 200,000 cst at room temperature;

from about 0.1 to 40% of a silicone surfactant;

from about 0.1 to 15% of a quaternized montmorillonite mineral; and

from 0.5 to 65% titanium dioxide in combination with pigments that, upon exposure to ambient air and moisture in skin, hardens to a water resistant, water vapor permeable, conformable solid film that colors the spots so they are shade matched with the surrounding non-hyperpigmented skin and remains unchanged in adherence and color to the spots for 24 hours after application and is thereafter applied to the spots every 12 to 72 hours to color the spots to shade match them to the surrounding untreated skin while whitening the treated spots over time while the pigmentation of the untreated surrounding non-hyperpigmented spots remains unchanged.

2. The method of claim 1 wherein the treatment composition is re-applied after the first application for a time sufficient to cause the discrete hyper-pigmented spots to whiten to match the untreated surrounding non-hyperpigmented skin.

3. The method of claim 2 wherein the treatment composition is applied for 4 to 60 days.

4. A method for whitening discrete hyper pigmented spots on skin by applying to the discrete spots in need of whitening and not to the surrounding non-hyper-pigmented skin, a treatment composition comprising a skin whitening active in a liquid polymeric coating comprising dimethicone silylate, isododecane, dimethicone, phenyl trimethicone, dimethicone copolyol, a quaternized montmorillonite mineral, polymethylmethacrylate, and titanium dioxide containing pigments, that, upon exposure to ambient air and moisture in skin hardens to a water resistant, water vapor permeable, adherent, conformable solid film that colors the spot to shade match the surrounding untreated non-hyperpigmented skin wherein the adherence of the treatment composition to the spots remains unchanged for 24 hours and the treatment composition is re-applied every 12 to 72 hours thereafter for a time sufficient to cause the treated discrete hyper-pigmented spots to match the surrounding non-hyperpigmented skin and whiten the spots over time while the untreated surrounding non-hyperpigmented skin remains unchanged.

5. The method of claim 4 wherein the treatment composition is applied every 12 to 72 hours for a period of 4 to 60 days.

6. A kit for whitening discrete hyper pigmented spots on the hands comprising:

a receptacle having a closure with a cap and extending rod having affixed at the distal end a deformable pinpoint applicator with an application surface of a size that permits application of a treatment composition to discrete hyperpigmented spots on the hands and not surrounding non-hyperpigmented skin, and stored within the receptacle a treatment composition comprising at least one skin whitening active in a polymeric coating material comprising 1-35% dimethicone silylate;

from 1-50% of a volatile solvent selected from the group consisting of isododecane, dimethicone and mixtures thereof;

from 1-50% of a non-volatile silicone oil having a viscosity of 20 to 200,000 cst at room temperature;

from about 0.1 to 40% of a silicone surfactant;

from about 0.1 to 15% of a quaternized montmorillonite mineral; and

from 0.5 to 65% titanium dioxide in combination with pigments that, upon exposure to ambient air and moisture in skin, hardens to a water resistant, water vapor permeable, adherent and conformable solid film that colors the spot so they are shade matched with the surrounding non-hyperpigmented skin;

wherein the adherence and color of the treatment composition to the spots on the hands remains unchanged for one day after application.

7. The kit of claim 6 wherein the applicator is a brush.

8. The kit of claim 6 wherein the pinpoint applicator is made from silicone or a thermoplastic material selected from the group consisting of polyurethane, polyethylene, or polypropylene.

9. The kit of claim 6 wherein the pinpoint applicator is made from thermoplastic polyurethane.

10. The kit of claim 9 wherein the pinpoint applicator is deformable.

11. The kit of claim 9 wherein the pinpoint applicator is flocked.

12. The kit of claim 6 wherein the applicator has an application surface from 5 to 25 millimeters in diameter.