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Second harmonic imaging nanoprobes and techniques for use thereof

  • US 9,476,830 B2
  • Filed: 11/21/2007
  • Issued: 10/25/2016
  • Est. Priority Date: 11/21/2006
  • Status: Active Grant
First Claim
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1. A second harmonic generating nanoprobe imager comprising:

  • at least one nanocrystal nanoprobe formed of a crystal material being associated with at least one biological target, the crystal material having a unit cell with no inversion symmetry such that the crystal material generates a second harmonic emission when radiated by an external excitation source;

    an external excitation source for radiating the nanocrystal nanoprobe at a frequency such that the crystal material of the nanocrystal nanoprobe generates a second harmonic emission; and

    a detector configured to collect a signal from the second harmonic emission, the signal identifying at least one biological target; and

    wherein the at least one nanocrystal nanoprobe generates the second harmonic emission regardless of the attachment and orientation of the nanocrystal nanoprobe to the at least one biological target.

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