Intrinsic frequency analysis for left ventricle ejection fraction or stroke volume determination
First Claim
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1. A system for acquiring and analyzing a hemodynamic waveform of a subject by Intrinsic Frequency (IF) analysis, the system comprising:
- a scanner adapted to capture a signal corresponding to a hemodynamic waveform; and
at least one computer processor connected to the scanner by a wired or wireless connection, wherein the computer processor is adapted to receive the signal for the hemodynamic waveform, determine a Dicrotic Notch using the signal, calculate first and second intrinsic frequencies (ω
1, ω
2) on each side of the Dicrotic Notch and at least one of other IF parameters including a1, b1, a2, b2, and c for the waveform, and output a signal corresponding to at least one of left ventricle ejection fraction (LVEF) and stroke volume (SV).
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Abstract
Hardware and software methodology are described for non-invasively monitoring cardiac health. Hemodynamic waveforms variously acquired for a subject are analyzed to calculate or approximate intrinsic frequencies in two domains in two domains across the Dicrotic Notch. Together with associated notch timing, heart rate and blood pressure values left ventricle ejection fraction and/or stroke volume can be determination.
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Citations
11 Claims
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1. A system for acquiring and analyzing a hemodynamic waveform of a subject by Intrinsic Frequency (IF) analysis, the system comprising:
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a scanner adapted to capture a signal corresponding to a hemodynamic waveform; and at least one computer processor connected to the scanner by a wired or wireless connection, wherein the computer processor is adapted to receive the signal for the hemodynamic waveform, determine a Dicrotic Notch using the signal, calculate first and second intrinsic frequencies (ω
1, ω
2) on each side of the Dicrotic Notch and at least one of other IF parameters including a1, b1, a2, b2, and c for the waveform, and output a signal corresponding to at least one of left ventricle ejection fraction (LVEF) and stroke volume (SV). - View Dependent Claims (2, 3)
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4. A non-transitory computer readable medium having stored thereon instructions, which when executed cause one or more processors to:
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determine a Dicrotic Notch using an input signal corresponding to a hemodynamic waveform; calculate, by Intrinsic Frequency (IF) analysis, first and second intrinsic frequencies (ω
1, ω
2) on each side of the Dicrotic Notch and at least one of other IF parameters including a1, b1, a2, b2, c for the hemodynamic waveform; andoutput a signal corresponding to at least one of left ventricle ejection fraction (LVEF) and stroke volume (SV). - View Dependent Claims (5, 6)
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7. A method of analyzing a signal using a computer comprising a processor, the method comprising:
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noninvasively acquiring a signal for a hemodynamic waveform of a subject with a sensor device, wherein the signal is acquired without calibrating the sensor device, and wherein the sensor device outputs signal magnitude by a selection of voltage, light intensity, microwave intensity, displacement or pressure; analyzing, by the processor, the signal magnitude of each of a first section and a second section of the hemodynamic waveform signal, wherein the waveform includes a Dicrotic Notch, to determine first and second intrinsic frequencies (ω
1, ω
2) on opposite sides of the Dicrotic Notch; andoutputting, by the processor, a result for at least one of left ventricle ejection fraction (LVEF) and stroke volume (SV). - View Dependent Claims (8, 9, 10, 11)
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Specification