Mineralization and biological modification of biomaterial surfaces
First Claim
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1. A method for controlling mineralization of a biomaterial surface, comprising:
- (a) functionalizing at least a first surface of a biomaterial; and
(b) contacting the functionalized biomaterial surface with an amount of a mineral-containing solution effective to form a mineralized biomaterial,wherein(i) the mineralized biomaterial comprises an extended, mineral coating at the functionalized biomaterial surface and is degradable over a controllable time scale; and
(ii) the biomaterial comprises at least a first porous, biodegradable polymer portion having an interconnected pore structure and further comprises at least a first portion that is prepared by a process comprising heating a biodegradable polymer.
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Abstract
Disclosed are advantageous methods for patterning and/or mineralizing biomaterial surfaces. The techniques described are particularly useful for generating three-dimensional or contoured bioimplant materials with patterned surfaces or patterned, mineralized surfaces. Also provided are various methods of using the mineralized and/or patterned biomaterials in tissue engineering, such as bone tissue engineering, providing more control over ongoing biological processes, such as mineralization, growth factor release, cellular attachment and tissue growth.
41 Citations
20 Claims
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1. A method for controlling mineralization of a biomaterial surface, comprising:
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(a) functionalizing at least a first surface of a biomaterial; and (b) contacting the functionalized biomaterial surface with an amount of a mineral-containing solution effective to form a mineralized biomaterial, wherein (i) the mineralized biomaterial comprises an extended, mineral coating at the functionalized biomaterial surface and is degradable over a controllable time scale; and (ii) the biomaterial comprises at least a first porous, biodegradable polymer portion having an interconnected pore structure and further comprises at least a first portion that is prepared by a process comprising heating a biodegradable polymer. - View Dependent Claims (2, 3, 4, 5, 6)
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7. A method for controlling mineralization of a biomaterial surface, said method comprising:
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(a) forming a biomaterial by heating a biodegradable polymer, said biomaterial comprising at least a first porous, biodegradable polymer portion that has an interconnected pore structure; (b) functionalizing a first surface of said biomaterial; and (c) contacting the functionalized biomaterial surface with an amount of a mineral-containing solution effective to form a mineralized biomaterial that comprises an extended, mineral coating at the functionalized biomaterial surface. - View Dependent Claims (8, 9, 10, 11, 12)
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13. A method for generating an extended, osteoconductive mineral coating on a surface of a porous, biodegradable polymer biomaterial, comprising:
contacting a surface of said porous, biodegradable polymer biomaterial with an amount of a mineral-containing solution effective to form an extended, osteoconductive mineral coating on said surface, wherein said porous, biodegradable polymer biomaterial has an interconnected pore structure and is degradable over a controllable time scale; and said biomaterial comprises at least a first portion that is prepared by a process comprising heating a biodegradable polymer. - View Dependent Claims (14, 15, 16, 17, 18, 19, 20)
Specification