Sensor system for drug delivery device, drug delivery device having the same and method of using the same

• US 9,480,795 B2
• Filed: 01/21/2009
• Issued: 11/01/2016
• Est. Priority Date: 01/21/2009
• Status: Active Grant

• Current Assignee: Xerox Corporation (Xerox Holdings Corp.)
• Original Assignee: Palo Alto Research Center, Inc. (Xerox Holdings Corp.)
• Inventors: Uhland, Scott Albert, Peeters, Eric, Preas, Bryan Thomas, Martini, Joerg
• Primary Examiner(s): Price, Nathan R
• Assistant Examiner(s): Snyder, Melissa A
• Application Number:
  US12/356,824
• Publication Number:
  US 20100185143A1
• Time in Patent Office: 2,841 Days
• Field of Search: 604 65- 66
• US Class Current: 1/1
• CPC Class Codes: A61M 2205/3303 Using a biosensor
• CPC Class Codes: A61M 2205/3306 Optical measuring means
• CPC Class Codes: A61M 2205/3317 Electromagnetic, inductive or dielectric measuring means
• CPC Class Codes: A61M 2205/3368 Temperature
• CPC Class Codes: A61M 5/16836 by sensing tissue properties at the infusion site, e.g. for detecting infiltration detecting tissue temperature for diagnostic purposes A61M39/0247
• CPC Class Codes: A61M 5/1684 by detecting the amount of infusate remaining, e.g. signalling end of infusion
• CPC Class Codes: A61M 5/1723 using feedback of body parameters, e.g. blood-sugar, pressure measurement of body parameters A61B5/00

Abstract

A system for use with a drug delivery device includes a sensor unit and a deactivation unit operatively coupled to an output of the sensor unit and to a drug-retaining region of the drug delivery device, wherein the drug-retaining region contains a drug. The sensor unit is configured to detect a characteristic of a local environment and generate an output corresponding to a value of the detected characteristic. The deactivation unit is configured to render the drug ineffective when the output of the sensor unit satisfies a predetermined condition.

Claims

1. A system for use with a drug delivery device, the system comprising:

a sensor unit; and

a deactivation unit operatively coupled to an output of the sensor unit and to a drug-retaining region of the drug delivery device, the drug-retaining region containing a drug, the deactivation unit having control circuitry and one of either an energy source or capsules, the deactivation unit to apply the energy or the capsules to the drug-retaining region,

wherein the sensor unit is configured to detect a characteristic of a local environment to determine if the device is connected to a user and generate an output corresponding to a value of the detected characteristic, and

wherein the deactivation unit is configured to render the drug ineffective by neutralizing the drug in the drug-retaining region when the output of the sensor unit satisfies a predetermined condition indicating that the device is not connected to the user.

2. The system of claim 1, wherein the local environment comprises the user.

3. The system of claim 1, wherein the local environment comprises a user-engageable element coupled to the drug delivery device.

4. The system of claim 1, wherein the characteristic of the local environment comprises at least one selected from the group consisting of a mechanical characteristic, a thermal characteristic, an electrical characteristic, an optical characteristic and a chemical characteristic.

5. The system of claim 1, wherein the predetermined condition is satisfied when the value of the detected characteristic of the local environment is outside a predetermined range.

6. The system of claim 1, wherein the predetermined condition is satisfied when the value of the detected characteristic of the local environment is within a predetermined range.

7. The system of claim 1, wherein the predetermined condition is satisfied when a rate at which the value of the detected characteristic of the local environment changes is outside a predetermined range.

8. The system of claim 1, wherein the predetermined condition is satisfied when the user engages with a user-engageable element coupled to the drug delivery device.

9. The system of claim 1, wherein the drug is transportable to the user from the drug-retaining region when the user is within an operable range of the drug delivery device and wherein the predetermined condition is satisfied when the user is outside the operable range of the drug delivery device.

10. A drug delivery device, comprising:

a drug-retaining region containing a drug;

a sensor unit, wherein the sensor unit is configured to detect a characteristic of a local environment to determine if the device is connected to a user and generate an output corresponding to a value of the detected characteristic; and

a deactivation unit operatively coupled to the drug-retaining region and to an output of the sensor unit, the deactivation unit configured to render the drug ineffective by neutralizing the drug in the drug-retaining region when the output of the sensor unit satisfies a predetermined condition indicating that the device is not connected to the user, the deactivation unit having control circuitry and one of either an energy source or capsules, the deactivation unit to apply the energy or the capsules to the drug-retaining region.

11. The drug delivery device of claim 10, wherein the drug delivery device includes at least one selected from the group consisting of an inhaler, a syringe, an intravenous bag, an implanted drug delivery system, a transdermal patch, a pill bottle, a liquid medicine bottle and an eyedropper.

12. The drug delivery device of claim 10, further comprising a housing, wherein the drug-retaining region is located within the housing, and wherein the sensor unit comprises at least one sensor coupled to the housing.

13. The drug delivery device of claim 12, wherein the deactivation unit comprises a neutralizing unit operatively coupled to the drug-retaining region, wherein the neutralizing unit is configured to neutralize the drug when the predetermined condition is satisfied.

14. The drug delivery device of claim 10, further comprising a user-engageable element, wherein a characteristic of the user-engageable element is detectable by the sensor unit when the user engages with the user-engageable element.

15. The drug delivery device of claim 10, further comprising:

when the deactivation unit comprises the energy source,

“

an energy source operatively coupled to the drug-retaining region,”

“

wherein”

the drug is transportable from the drug-retaining region to the user upon application of energy from the energy source to the drug-retaining region, and

wherein the deactivation unit “

is operatively couple to the energy source and”

is further configured to discontinue the application of energy from the energy source to the drug-retaining region when the output of the sensor unit satisfies the predetermined condition.