Water equivalent depth measurement for providing a continuous calibration range based on discrete measurements

• US 9,480,862 B2
• Filed: 03/06/2012
• Issued: 11/01/2016
• Est. Priority Date: 03/07/2011
• Status: Active Grant

• Current Assignee: Ion Beam Applications s.a.
• Original Assignee: Ion Beam Applications s.a.
• Inventors: Gottschalk, Bernard, Jongen, Yves
• Primary Examiner(s): Ippolito, Nicole
• Assistant Examiner(s): LUCK, SEAN M
• Application Number:
  US13/412,734
• Publication Number:
  US 20120228493A1
• Time in Patent Office: 1,701 Days
• Field of Search: 250/307
• US Class Current: 1/1
• CPC Class Codes: A61N 2005/1087 Ions; Protons
• CPC Class Codes: A61N 5/103 Treatment planning systems
• CPC Class Codes: A61N 5/1075 for testing, calibrating, or quality assurance of the radiation treatment apparatus

Abstract

A method for determining a water equivalent depth between an entrance point and a reference point is disclosed. The method may comprise sending to a charged particle beam detector placed at a reference point within or beyond a body a charged particle beam whose energy is modulated between a minimum and maximum energy value, acquiring the time dependent response of said charged particle beam detector, determining from said time dependent response a value of a statistical parameter, providing a calibration curve expressing a relationship between values of said statistical parameter and water equivalent depths, and extracting from this calibration curve the water equivalent depth corresponding to the value of the statistical parameter determined from the time dependent response of the charged particle beam detector placed at the reference point.

Claims

1. A computer-implemented method for determining a water equivalent depth, between an entrance point and a reference point, of a charged particle beam sent towards a body, wherein said entrance point lies on an external surface of the body, and wherein said reference point corresponds to a location of a charged particle beam detector, the method comprising:

providing a beam output apparatus for delivering a charged particle beam to said body in a beam direction defined from said entrance point to said reference point;

choosing a maximum energy value such that a charged particle beam, sent by the beam output apparatus and having said maximum energy value and being sent in said beam direction, would penetrate the body from said entrance point up to at least said reference point;

choosing a minimum energy value such that a charged particle beam, sent by the beam output apparatus and having said minimum energy value and being sent in said beam direction, would penetrate the body from said entrance point and would be stopped in said body before reaching said reference point;

sending in said beam direction, from said beam output apparatus, a charged particle beam that is time modulated in energy between said minimum energy value and said maximum energy value;

acquiring, in response to the sent charged particle beam, a time-dependent response of the charged particle beam detector;

calculating a first statistical value reflecting a statistical moment of said time-dependent response;

generating, based on a discrete measurement of a plurality of statistical moments of prior time-dependent responses, a pre-determined calibration curve that expresses a continuous range of water equivalent depths as a function of second statistical values based on the discrete measurement of the plurality of statistical moments of the prior time-dependent responses; and

determining, from said generated pre-determined calibration curve, the water equivalent depth, between the entrance point and the reference point corresponding to the first statistical value, of the charged particle beam output by the beam output apparatus.

2. The method of claim 1, wherein said reference point is positioned inside said body.

3. The method of claim 1, wherein said reference point is positioned outside said body.

4. The method of claim 1, wherein the charged particle beam detector comprises a semiconductor diode for detecting the charged particle beam.

5. The method of claim 4, wherein said semiconductor diode is connected to an input of a transimpedance amplifier, and wherein said time-dependent response is measured at an output of said transimpedance amplifier.

6. The method of claim 5, wherein said transimpedance amplifier includes a first transimpendance amplifier, an inverting voltage amplifier with a gain ranging between 35 and 45, and an output stage having a gain between the input and the output of said transimpedance amplifier ranging between 0.4 V/nA and 0.6 V/nA.

7. The method of claim 1, wherein the pre-determined calibration curve is obtained by:

(1) positioning said charged particle beam detector at a given position in a water or water-equivalent calibration phantom;

(2) sending to said charged particle beam detector the charged particle beam that is time modulated in,energy between said minimum and said maximum energy value;

(3) acquiring a time-dependent response of said charged particle beam detector;

(4) calculating at least one of a root mean square width, a skewness value, or a kurtosis value of said time-dependent response;

(5) determining a corresponding water equivalent depth of the time-dependent response, said corresponding water equivalent depth being the distance between the entrance point of said charged particle beam in said calibration phantom and said given position;

(6) repeating steps (1) to (5) more than one time; and

(7) establishing a calibration curve that expresses the corresponding determined water equivalent depths as a function of the root mean square widths, skewness values, or kurtosis values.

8. The method of claim 1, wherein the charged particle beam detector comprises an array of semiconductor diodes placed transversally with respect to the charged particle beam.

18. The method of claim 1, further comprising:

controlling the beam output apparatus based on the determined water equivalent depth.

19. The method of claim 1, wherein the first statistical value is one of a root mean square width, a skewness value, or a kurtosis value.

23. The method of claim 1, wherein generating a pre-determined calibration curve comprises:

acquiring a plurality of time-dependent responses of the charged particle beam detector at a respective plurality of known depths;

calculating the second statistical values for each of the plurality of time-dependent responses; and

interpolating a plot of the second statistical values as a function of the respective plurality of known depths.

24. The method of claim 1, wherein the first statistical value is solely a function of said time-dependent response.

9. A device for determining a water equivalent depth between an entrance point and a reference point of a charged particle beam sent towards a body, wherein said entrance point lies on an external surface of the body, said device comprising:

a charged particle beam detector that is placed at the reference point;

a processor configured to acquire a time-dependent response of said charged particle beam detector from a charged particle beam that is time modulated in energy;

a processor configured to calculate a first statistical value reflecting a statistical moment of said time-dependent response response;

a processor configured to generate, based on a discrete measurement of a plurality of statistical moments of prior time dependent responses, a pre-determined calibration curve that expresses a continuous range of water equivalent depths as a function of second statistical values based on the discrete measurement of the plurality of statistical moments of the prior time-dependent responses; and

a processor configured to determine from said generated pre-determined calibration curve the water equivalent depth corresponding to the first statistical value of the time-dependent response of the charged particle beam detector placed at the reference point.

10. The device of claim 9, wherein the charged particle beam detector comprises a semiconductor diode.

11. The device of claim 10, wherein said semiconductor diode is connected to an input of a transimpedance amplifier, and in that said time-dependent response is measured at an output of said transimpedance amplifier.

12. The device of claim 11, wherein the charged particle beam detector comprises an array of semiconductor diodes placed transversally with respect to the charged particle beam.

16. The device of claim 9, further comprising:

a processor configured to determine statistical probabilities of skewness and/or kurtosis for said time-dependent response; and

a processor configured to compute a range mixing parameter which is an indicator of observed deviations in said statistical probabilities of at least one of skewness or kurtosis when compared with values obtained during a calibration measurement using a water phantom.

20. The device of claim 9, wherein the first statistical value is one of a root mean square width, a skewness value, or a kurtosis value.

13. A method for determining a water equivalent depth between a number of entrance points and a number of corresponding reference points, said entrance points being located on an external surface of a body, said corresponding reference points being points where a corresponding charged particle beam detector is placed, the method, for each entrance point and corresponding reference point, comprising:

providing a beam output apparatus for delivering a charged particle beam to said body in a beam direction defined from an entrance point to the correspond reference point;

choosing a maximum energy value such that a charged particle beam, sent by the beam output apparatus and having said maximum energy value and being sent in said beam direction, would penetrate the body from said entrance point up to at least said reference point;

choosing a minimum energy value such that a charged particle beam, sent by the beam output apparatus and having said minimum energy value and being sent in said beam direction, would penetrate the body from said entrance point and would be stopped in said body before reaching said reference point;

sending in said beam direction, from said beam output apparatus, a charged particle beam that is time modulated in energy between said minimum energy value and said maximum energy value;

acquiring a time-dependent response of the charged particle beam detector;

wherein, for each time-dependent response curve obtained for each of the said corresponding detectors, further comprising the steps of;

calculating a corresponding statistical value reflecting a statistical moment of the time-dependent response;

generating, based on a discrete measurement of a plurality of statistical moments of prior time-dependent responses, a pre-determined calibration curve that expresses a continuous range of water equivalent depths as a function of second statistical values based on the discrete measurement of the statistical moments of the plurality of prior time-dependent responses; and

determining from said generated pre-determined calibration curve the water equivalent depth between the entrance point and the reference point corresponding to the corresponding statistical value.

14. The method of claim 13, further comprising, for each time-dependent response acquired for each of the corresponding charged particle beam detectors, the steps of:

determining statistical probabilities of skewness and/or kurtosis with respect to the time-dependent response curve;

comparing statistical probabilities of skewness and/or kurtosis obtained in the previous step with values obtained during a calibration measurement using a water phantom;

computing a range mixing parameter which is an indicator of deviations in the compared statistical probabilities of skewness and/or kurtosis; and

classifying the beam detectors according to the range mixing parameter.

21. The method of claim 13, wherein the first statistical value is one of a root mean square width, a skewness value, or a kurtosis value.

15. A method for determining range mixing when a water equivalent depth between a number of entrance points and a number of corresponding reference points is being measured using a charged particle beam, said entrance points being located on an external surface of a body, said corresponding reference points being points where a corresponding charged particle beam detector is placed, the method, for each entrance point and corresponding reference point, comprising:

providing an apparatus for delivering a charged particle beam to said body in a beam direction defined from an entrance point to the correspond reference point;

choosing a maximum energy value such that a charged particle beam having said maximum energy value and being sent in said beam direction penetrates the body from said entrance point up to at least said reference point;

choosing a minimum energy value such that a charged particle beam having said minimum energy value and being sent in said beam direction penetrates the body from said entrance point and is stopped in said body before reaching said reference point;

sending in said beam direction a charged particle beam that is time modulated in energy between said minimum energy value and said maximum energy value;

acquiring a time-dependent response of the charged particle beam detector;

wherein, for each time-dependent response curve obtained for each of the said corresponding detectors, further comprising the steps of;

determining a first statistical value based on a first statistical moment with respect to the time-dependent response curve;

comparing the first statistical moment obtained in the previous step with a pre-determined calibration curve that expresses a continuous range of water equivalent depths as a function of second statistical values based on a discrete measurement of statistical moments of a plurality of prior time-dependent responses;

computing a range mixing parameter which is an indicator of the observed deviations in the first statistical moment; and

classifying the beam detectors according to the range mixing parameter.

17. A device configured to determine a water equivalent depth between an entrance point and a reference point, said entrance point lying on an external surface of a body, said reference point being a point at which a charged particle beam detector is placed, the device comprising:

a processor configured to acquire a time-dependent response of said charged particle beam detector from a charged particle beam that is time modulated in energy;

a processor configured to calculate a first statistical value reflecting a statistical moment of said time-dependent response;

a processor configured to generate, based on a discrete measurement of a plurality of statistical moments of prior time-dependent responses, a pre-determined calibration curve that expresses a continuous range of water equivalent depths as a function of second statistical values based on the discrete measure of the plurality of statistical moments of the prior time-dependent responses; and

a processor configured to determine from said generated pre-determined calibration curve the water equivalent depth corresponding to the first statistical value of the time-dependent response of the charged particle beam detector placed at the reference point.

22. The device of claim 17, wherein the first statistical value is one of a root mean square width, a skewness value, or a kurtosis value.