Sample collection and transfer device
First Claim
1. An integrated device for a sample collection and transfer, comprising:
- a capillary channel disposed between a first layer and a second layer, wherein the first layer comprises a hydrophilic layer comprising a fluid inlet for receiving a sample fluid to the capillary channel, wherein the capillary channel comprises an inner surface and an outer surface; and
an outlet for allowing the sample fluid to flow out of the capillary channel; and
an interface assembly comprising;
a third layer comprising an adhesive material, a fourth layer comprising a hydrophilic material, a fifth layer comprising a patterned adhesive material, and a flow path, wherein the third layer is disposed on the fourth layer and the fourth layer is disposed on the fifth layer;
wherein the interface assembly is disposed on the outer surface of the capillary, at a determining position relative to the outlet, such that the capillary is in contact with the third layer of the interface assembly and the outlet is in contact with the flow path of the interface assembly for transfering the sample fluid out of the integrated device;
wherein the integrated device is coupled to a substrate and configured to transfer the sample fluid to the substrate.
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Accused Products
Abstract
An integrated device for a sample collection and transfer is provided. The integrated device comprises a capillary channel disposed between a first layer and a second layer, wherein the first layer comprises a hydrophilic layer comprising a fluid inlet for receiving a sample fluid to the capillary channel, wherein the capillary channel comprises an inner surface and an outer surface and an outlet for driving out the sample fluid. The device further comprises an interface assembly comprising: a third layer, a fourth layer, a fifth layer, and a flow path. The interface assembly is disposed on the outer surface of the capillary, at a determining position relative to the outlet, such that the capillary is in contact with the third layer of the interface assembly and the outlet is in contact with the flow path of the interface assembly for driving out the sample fluid from the integrated device.
22 Citations
32 Claims
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1. An integrated device for a sample collection and transfer, comprising:
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a capillary channel disposed between a first layer and a second layer, wherein the first layer comprises a hydrophilic layer comprising a fluid inlet for receiving a sample fluid to the capillary channel, wherein the capillary channel comprises an inner surface and an outer surface; and
an outlet for allowing the sample fluid to flow out of the capillary channel; andan interface assembly comprising;
a third layer comprising an adhesive material, a fourth layer comprising a hydrophilic material, a fifth layer comprising a patterned adhesive material, and a flow path, wherein the third layer is disposed on the fourth layer and the fourth layer is disposed on the fifth layer;wherein the interface assembly is disposed on the outer surface of the capillary, at a determining position relative to the outlet, such that the capillary is in contact with the third layer of the interface assembly and the outlet is in contact with the flow path of the interface assembly for transfering the sample fluid out of the integrated device; wherein the integrated device is coupled to a substrate and configured to transfer the sample fluid to the substrate. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23)
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24. A system, comprising:
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a substrate; and an integrated device comprising; a capillary channel disposed between a first layer and a second layer, wherein the first layer comprises a hydrophilic layer comprising a fluid inlet for receiving a sample fluid to the capillary channel and wherein the capillary channel comprises an inner surface and an outer surface; and
an outlet connected to the capillary channel; andan interface assembly comprising;
a third layer comprising an adhesive material, a fourth layer comprising a hydrophilic material, a fifth layer comprising a patterned adhesive material and a flow path, wherein the third layer is disposed on the fourth layer and the fourth layer is disposed on the fifth layer;wherein the interface assembly is disposed on the outer surface of the capillary, at a determining position relative to the outlet, such that the capillary channel is in connection with the flow path of the interface assembly; wherein the integrated device is operatively coupled to the substrate such that substrate is in contact with the interface assembly for transferring the sample fluid from the integrated device to the substrate. - View Dependent Claims (25, 26)
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27. A method for sample collection and transfer, comprising:
providing an integrated device, wherein the device comprises; a capillary channel disposed between a first layer and a second layer, wherein the first layer comprises a hydrophilic layer comprising a fluid inlet for receiving a sample fluid to the capillary channel, wherein the capillary channel comprises an inner surface and an outer surface; and
an outlet for allowing the fluid to flow out from the device; andan interface assembly comprising;
a third layer comprising an adhesive material, a fourth layer comprising a hydrophilic material, a fifth layer comprising a patterned adhesive material, and a flow path, wherein the third layer is disposed on the fourth layer and the fourth layer is disposed on the fifth layer;
wherein the interface assembly is disposed on the outer surface of the capillary, at a determining position relative to the outlet, such that the capillary channel is in connection with the flow path of the interface assembly;contacting the integrated device to a substrate comprising an absorbent material; applying a fluid sample to the capillary inlet of the integrated device, wherein the fluid sample is transported from the inlet to the outlet of the capillary; and transferring the fluid from the integrated device to the substrate through the flow path of the interface assembly; wherein the sample collection and transfer is achieved at least in 10 seconds. - View Dependent Claims (28, 29, 30, 31)
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32. A method for sample collection and transfer, comprising:
providing an integrated device, wherein the device comprises; a capillary channel disposed between a first layer and a second layer, wherein the first layer comprises a hydrophilic layer comprising a fluid inlet for receiving a sample fluid to the capillary channel, wherein the capillary channel comprises an inner surface and an outer surface; and
an outlet for driving out the sample fluid; andan interface assembly comprising;
a third layer comprising an adhesive material, a fourth layer comprising a hydrophilic material, a fifth layer comprising a patterned adhesive material, and a flow path, wherein the third layer is disposed on the fourth layer and the fourth layer is disposed on the fifth layer;
wherein the interface assembly is disposed on the outer surface of the capillary, at a determining position relative to the outlet, such that the capillary channel is in connection with the flow path of the interface assembly;contacting the device to the substrate comprising an absorbent material; applying a fluid sample to the capillary inlet of the integrated device, wherein the fluid sample is transported from the inlet to the outlet of the capillary; and transferring the fluid from the integrated device to the substrate through the flow path of the interface assembly, wherein the sample collection and transfer is achieved in at least 10 seconds; and analyzing a portion of the substrate comprising the fluid sample transferred from the device.
Specification