Apparatus for process automation using a pin and bushing array

• US 9,480,987 B2
• Filed: 10/08/2013
• Issued: 11/01/2016
• Est. Priority Date: 11/07/2005
• Status: Active Grant

• Current Assignee: Boone, Charles, Sasan Raghibizadeh
• Original Assignee: Boone, Charles, Sasan Raghibizadeh
• Inventors: Raghibizadeh, Sasan, Boone, Charles
• Primary Examiner(s): Logan, Kyle
• Application Number:
  US14/048,216
• Publication Number:
  US 20140039671A1
• Time in Patent Office: 1,120 Days
• Field of Search: 700/230
• US Class Current: 1/1
• CPC Class Codes: A61L 2/24 Apparatus using programmed or automatic operation
• CPC Class Codes: B01L 13/02 for receptacle or instruments
• CPC Class Codes: B01L 2300/0819 Microarrays; Biochips
• CPC Class Codes: B01L 9/52 Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips
• CPC Class Codes: B01L 9/543 for disposable pipette tips, e.g. racks or cassettes
• CPC Class Codes: B01L 9/547 for dispensing pins
• CPC Class Codes: G01N 2035/00326 Analysers with modular structure
• CPC Class Codes: G01N 2035/042 moved independently, e.g. by fork manipulator
• CPC Class Codes: G01N 2035/1037 Using surface tension, e.g. pins or wires
• CPC Class Codes: G01N 35/0099 comprising robots or similar manipulators robots per se B25J
• CPC Class Codes: G01N 35/1011 Control of the position or alignment of the transfer device
• CPC Class Codes: G01N 35/1074 arranged in a two-dimensional array

Abstract

An apparatus and method for transferring plurality of samples from one sample container to another one is disclosed wherein each sample is randomly accessible and can be “cherry picked”. The disclosed method of actuation allows for using a smaller number of actuators than the number of sample transferring channels or pins and thereby simplifies the design and control of the sample transferring apparatus.

Claims

1. An apparatus, comprising:

a plurality of functional modules, each functiona mod u e comprising a tool interface, the tool interface capable of moving independently and along a first axis and a second axis, each tool interface to interface with at least one tool to operate on work samples;

a conveyer to transfer work samples from at least one of the plurality of functional modules to another functional module or another module or instrument, the conveyor capable of movement along a third axis perpendicular to the first and second axes; and

a controller for coordinating the operation of the plurality of functional modules and the conveyer;

wherein, the plurality of functional modules are substantially identical to each other in terms of the tool interface and ability to move in the first and second axes.

2. The apparatus of claim 1, wherein the first axis is a horizontal axis and the second axis is a vertical axis, thereby taking advantage of vertical space and minimizing apparatus footprint.

3. The apparatus of claim 1, further comprising:

a first tool to interface with a first functional module of the at least one functional module, the first tool comprising one or more of a gripper, a pipettor, a pinhead, a bar-code reader, a charge-coupled device camera, a re-arrayer pinhead, a magnetic pinhead, a suction manifold, a dispense manifold, a micro-arraying print-head, or a combination of such tools.

4. The apparatus of claim 1, further comprising:

at least one sub-module to cooperatively operate with at least one functional module in the plurality of functional modules on work samples or tools, thus the sub-module to be within the work space of that functional module such that the sub-module to be accessible by at least one tool of the functional module.

5. The apparatus of claim 4, the at least one sub-module comprising one or more of a stacker, a carousel, a stacker with incubator, a carousel with incubator an incubator, a wash tower, a shaker, a centrifuge, a vacuum filtration manifold, a plate reader, a slide scanner, a gel reader, a magnetic stirrer, a piercer, a thermocycler, a plate sealer, a plate washer, a plate filler, a liquid handler, a plate heater a plate imager, a scale, a dryer a reagent library, or a combination of such modules.

8. The apparatus of claim 4, wherein the at least one functional module isinstalled on a moving base whereby the at least one functional module can travel horizontally and/or rotate along the the vertical axis to access one or more sub-modules.

12. The apparatus of claim 1, wherein the conveyer comprises a tray, the tray comprising at least one sample plate holder, the sample plate holder configured to locate a sample plate on the tray, wherein the conveyor and each functional module are located with respect to each other so that the tool of t he tool interface can reach and operate on the sample plate while the sample plate is on the conveyor.

13. The apparatus of claim 1, wherein the conveyer comprises a tray, the tray comprising at least one sample plate holder, the sample plate holder configured to locate a sample plate on the tray, wherein the conveyor and each functional module are located with respect to each other so that so that the conveyer can position the tray with respect to the tool of the tool interface for the said location of the plate on the tray.

14. The apparatus of claim 12, wherein the conveyer comprises a tray, the tray comprising at least one sample plate holder, the sample plate holder configured to locate a sample plate on the tray, wherein the conveyor and each functional module are located with respect to each other so that so that the conveyer can position the tray with respect to the tool of the tool interface for the said location of the plate on the tray.

6. An apparatus, comprising:

at least one functional module, each functional module comprising a tool a second axis, each tool interface to interface with at least one tool to operate on work samples;

a conveyer to transfer work samples from the at least one functional module to another functional module or another module or instrument, the conveyor capable of movement along a third axis perpendicular to the first and second axes; and

a controller for coordinating the operation of the at least one functional module and the conveyer;

wherein, when a plurality of functional modules are present, the functional modules are substantially identical, wherein the conveyer comprises a tray, the tray comprising at least one sample plate holder, the sample plate holder configured to locate a sample plate on the tray.

9. The apparatus of claim 6, further comprising locking actuators for locking the sample plate on the tray, each locking actuator controlled by the controller for opening and closing.

10. The apparatus of claim 6, wherein the sample plate holder has locating pins for locating the sample plate on the tray.

11. The apparatus of claim 9, wherein the sa p plain holder has locating pins for locating the sample plate on the tray.

7. An apparatus, comprising:

at least one functional module, each functional module comprising a tool interface, the tool interface capable of moving independently and along a first axis and a second axis, each tool interface to interface with at least one tool to operate on work samples;

a conveyer to transfer work samples from the at least one functional module to another functional module or another module or instrument, the conveyor capable of movement along a third axis perpendicular to the first and second axes;

a controller for coordinating the operation of the at least one functional module and the conveyer;

wherein, when a plurality of functional modules are present, the functional odules are substantially identical,

a first sub-module to cooperatively operate on work samples with the at least one functional module,

wherein the first sub-module further comprises;

a plurality of devices arranged vertically, each device to complete one step of a plurality of cleaning or sterilization steps of a tool;

the apparatus to serve in an automation apparatus, whereby the vertical arrangement of the plurality of devices takes advantage of vertical space and minimizes apparatus footprint.