2′-substituted carba-nucleoside analogs for antiviral treatment
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Abstract
Provided are compounds of Formula I,
as well as pharmaceutical compositions containing compounds of Formula I and methods for treating Orthomyxoviridae virus infections by administering these compounds. The compounds, compositions, and methods provided are particularly useful for the treatment of Human Influenza virus infections.
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55 Claims
- 1. A compound of Formula I:
-
18. A compound selected from the group consisting of
- 25. A method for treating an Orthomyxoviridae infection in a mammal in need thereof comprising administering a therapeutically effective amount of a compound of Formula I:
- 42. A method for treating an Orthomyxoviridae infection in a mammal in need thereof comprising administering a therapeutically effective amount of a compound, wherein the compound is
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