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Engineered renal tissues, arrays thereof, and methods of making the same

  • US 9,481,868 B2
  • Filed: 10/06/2015
  • Issued: 11/01/2016
  • Est. Priority Date: 10/06/2014
  • Status: Active Grant
First Claim
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1. A three-dimensional, engineered, bioprinted, biological renal tubule model comprising:

  • a. a layer of renal interstitial tissue, the renal interstitial tissue comprising renal fibroblasts and endothelial cells; and

    b. a layer of renal epithelial tissue, the renal epithelial tissue comprising renal tubular epithelial cells, the renal epithelial tissue in contact with the layer of renal interstitial tissue to form the three-dimensional, engineered, biological renal tubule model;

    provided that the interstitial tissue comprises an interstitial bio-ink, the epithelial tissue comprises an epithelial bio-ink, and form a three-dimensional, engineered, biological renal tubule model; and

    wherein the fibroblasts and endothelial cells are the only cells present in the layer of renal interstitial tissue and are present in a ratio of fibroblasts to endothelial cells at which the renal tubule model is planar six days post-printing.

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