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Arrays and methods of use

  • US 9,481,883 B2
  • Filed: 07/22/2015
  • Issued: 11/01/2016
  • Est. Priority Date: 03/16/2001
  • Status: Expired due to Term
First Claim
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1. A method of producing a molecular array comprising:

  • providing a solid support comprising a plurality of physically discrete elements, wherein one element of said plurality of physically discrete elements is separated from another element of said plurality of physically discrete elements by one or more raised regions or trenches and each of said plurality of physically discrete elements is arranged at predetermined locations on said solid support and is separated by a fixed distance; and

    immobilizing a plurality of target oligonucleotide molecules onto said plurality of physically discrete elements, thereby producing immobilized target oligonucleotide molecules and a molecular array comprising said plurality of physically discrete elements having said immobilized target oligonucleotide molecules, wherein each of said plurality of physically discrete elements of the molecular array contains only one of said immobilized target oligonucleotide molecules.

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