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Determination of neuropsychiatric therapy mechanisms of action

  • US 9,483,613 B2
  • Filed: 09/16/2015
  • Issued: 11/01/2016
  • Est. Priority Date: 07/08/2008
  • Status: Expired due to Fees
First Claim
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1. A computer implemented method of assessing neuroimaging and medical data to determine mechanisms of action for neuropsychiatric therapies, the computer implemented method comprising:

  • receiving, at a processor via a network connection, neuroimaging data of a first set of human brain scans for each human subject in a plurality of human subjects diagnosed with a given neuropsychiatric condition generated at a first time period prior to beginning implementation of a neuropsychiatric therapy to treat the given neuropsychiatric condition and a second set of human brain scans for the each human subject in the plurality of human subjects diagnosed with the given neuropsychiatric condition generated at a second time period of a given amount of time after beginning the implementation of the neuropsychiatric therapy to treat the given neuropsychiatric condition, wherein a set of one or more scanning devices generate the neuroimaging data of the first set of human brain scans and the second set of human brain scans, and wherein the neuropsychiatric therapy is received by the each human subject in the plurality of human subjects diagnosed with the given neuropsychiatric condition;

    automatically searching, using the processor, via the network connection a set of online electronic medical literature sources for portions of medical literature describing the neuropsychiatric therapy used to treat the given neuropsychiatric condition;

    automatically identifying, using the processor, a first set of regions of interest in the first set of human brain scans for the each human subject in the plurality of human subjects diagnosed with the given neuropsychiatric condition generated at the first time period prior to beginning the implementation of the neuropsychiatric therapy to treat the given neuropsychiatric condition and a second set of regions of interest in the second set of human brain scans for the each human subject in the plurality of human subjects diagnosed with the given neuropsychiatric condition generated at the second time period of the given amount of time after beginning the implementation of the neuropsychiatric therapy to treat the given neuropsychiatric condition;

    identifying, using the processor, a set of changes in the neuroimaging data of the first set of human brain scans and the second set of human brain scans for the each human subject in the plurality of human subjects diagnosed with the given neuropsychiatric condition based on a comparison of the first set of regions of interest for the each human subject with the second set of regions of interest for the each human subject, wherein the set of changes comprises indicators of change occurring after the each human subject began receiving the neuropsychiatric therapy to treat the given neuropsychiatric condition;

    analyzing, using the processor, the set of changes for the each human subject with the portions of the medical literature describing the neuropsychiatric therapy used to treat the given neuropsychiatric condition to identify a set of changes attributable to the neuropsychiatric therapy;

    generating, using the processor, a mechanism of action for the neuropsychiatric therapy for the plurality of human subjects diagnosed with the given neuropsychiatric condition based on the analyzing of the set of changes for the each human subject, wherein the mechanism of action comprises a set of links to the portions of the medical literature associated with the neuropsychiatric therapy and each change in the set of changes identified from an automatic searching of the set of online electronic medical literature sources;

    generating, using the processor, the set of links to the portions of the medical literature associated with the neuropsychiatric therapy used to treat the given neuropsychiatric condition; and

    embedding, using the processor, the set of links to the portions of the medical literature associated with the neuropsychiatric therapy used to treat the given neuropsychiatric condition within the first set of regions of interest located in the first set of human brain scans for the each human subject in the plurality of human subjects diagnosed with the given neuropsychiatric condition and the second set of regions of interest located in the second set of human brain scans for the each human subject in the plurality of human subjects diagnosed with the given neuropsychiatric condition.

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