Determination of neuropsychiatric therapy mechanisms of action
First Claim
1. A computer implemented method of assessing neuroimaging and medical data to determine mechanisms of action for neuropsychiatric therapies, the computer implemented method comprising:
- receiving, at a processor via a network connection, neuroimaging data of a first set of human brain scans for each human subject in a plurality of human subjects diagnosed with a given neuropsychiatric condition generated at a first time period prior to beginning implementation of a neuropsychiatric therapy to treat the given neuropsychiatric condition and a second set of human brain scans for the each human subject in the plurality of human subjects diagnosed with the given neuropsychiatric condition generated at a second time period of a given amount of time after beginning the implementation of the neuropsychiatric therapy to treat the given neuropsychiatric condition, wherein a set of one or more scanning devices generate the neuroimaging data of the first set of human brain scans and the second set of human brain scans, and wherein the neuropsychiatric therapy is received by the each human subject in the plurality of human subjects diagnosed with the given neuropsychiatric condition;
automatically searching, using the processor, via the network connection a set of online electronic medical literature sources for portions of medical literature describing the neuropsychiatric therapy used to treat the given neuropsychiatric condition;
automatically identifying, using the processor, a first set of regions of interest in the first set of human brain scans for the each human subject in the plurality of human subjects diagnosed with the given neuropsychiatric condition generated at the first time period prior to beginning the implementation of the neuropsychiatric therapy to treat the given neuropsychiatric condition and a second set of regions of interest in the second set of human brain scans for the each human subject in the plurality of human subjects diagnosed with the given neuropsychiatric condition generated at the second time period of the given amount of time after beginning the implementation of the neuropsychiatric therapy to treat the given neuropsychiatric condition;
identifying, using the processor, a set of changes in the neuroimaging data of the first set of human brain scans and the second set of human brain scans for the each human subject in the plurality of human subjects diagnosed with the given neuropsychiatric condition based on a comparison of the first set of regions of interest for the each human subject with the second set of regions of interest for the each human subject, wherein the set of changes comprises indicators of change occurring after the each human subject began receiving the neuropsychiatric therapy to treat the given neuropsychiatric condition;
analyzing, using the processor, the set of changes for the each human subject with the portions of the medical literature describing the neuropsychiatric therapy used to treat the given neuropsychiatric condition to identify a set of changes attributable to the neuropsychiatric therapy;
generating, using the processor, a mechanism of action for the neuropsychiatric therapy for the plurality of human subjects diagnosed with the given neuropsychiatric condition based on the analyzing of the set of changes for the each human subject, wherein the mechanism of action comprises a set of links to the portions of the medical literature associated with the neuropsychiatric therapy and each change in the set of changes identified from an automatic searching of the set of online electronic medical literature sources;
generating, using the processor, the set of links to the portions of the medical literature associated with the neuropsychiatric therapy used to treat the given neuropsychiatric condition; and
embedding, using the processor, the set of links to the portions of the medical literature associated with the neuropsychiatric therapy used to treat the given neuropsychiatric condition within the first set of regions of interest located in the first set of human brain scans for the each human subject in the plurality of human subjects diagnosed with the given neuropsychiatric condition and the second set of regions of interest located in the second set of human brain scans for the each human subject in the plurality of human subjects diagnosed with the given neuropsychiatric condition.
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Abstract
A computer implemented method, apparatus, and computer program product of determining mechanisms of action for therapies. A first set of brain scans for each subject in a plurality of subjects generated at a first time period and a second set of brain scans for each subject generated at a second time period are received. Each subject is diagnosed with a given condition and received a given therapy. A set of changes in the set of brain scans is identified for the each subject based on a comparison of a first set of regions of interest in the first set of scans for each subject with a second set of regions of interest in the second set of scans for each subject. A set of typical changes attributable to the given therapy is identified. A mechanism of action for the given therapy is generated based on the set of typical changes.
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Citations
22 Claims
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1. A computer implemented method of assessing neuroimaging and medical data to determine mechanisms of action for neuropsychiatric therapies, the computer implemented method comprising:
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receiving, at a processor via a network connection, neuroimaging data of a first set of human brain scans for each human subject in a plurality of human subjects diagnosed with a given neuropsychiatric condition generated at a first time period prior to beginning implementation of a neuropsychiatric therapy to treat the given neuropsychiatric condition and a second set of human brain scans for the each human subject in the plurality of human subjects diagnosed with the given neuropsychiatric condition generated at a second time period of a given amount of time after beginning the implementation of the neuropsychiatric therapy to treat the given neuropsychiatric condition, wherein a set of one or more scanning devices generate the neuroimaging data of the first set of human brain scans and the second set of human brain scans, and wherein the neuropsychiatric therapy is received by the each human subject in the plurality of human subjects diagnosed with the given neuropsychiatric condition; automatically searching, using the processor, via the network connection a set of online electronic medical literature sources for portions of medical literature describing the neuropsychiatric therapy used to treat the given neuropsychiatric condition; automatically identifying, using the processor, a first set of regions of interest in the first set of human brain scans for the each human subject in the plurality of human subjects diagnosed with the given neuropsychiatric condition generated at the first time period prior to beginning the implementation of the neuropsychiatric therapy to treat the given neuropsychiatric condition and a second set of regions of interest in the second set of human brain scans for the each human subject in the plurality of human subjects diagnosed with the given neuropsychiatric condition generated at the second time period of the given amount of time after beginning the implementation of the neuropsychiatric therapy to treat the given neuropsychiatric condition; identifying, using the processor, a set of changes in the neuroimaging data of the first set of human brain scans and the second set of human brain scans for the each human subject in the plurality of human subjects diagnosed with the given neuropsychiatric condition based on a comparison of the first set of regions of interest for the each human subject with the second set of regions of interest for the each human subject, wherein the set of changes comprises indicators of change occurring after the each human subject began receiving the neuropsychiatric therapy to treat the given neuropsychiatric condition; analyzing, using the processor, the set of changes for the each human subject with the portions of the medical literature describing the neuropsychiatric therapy used to treat the given neuropsychiatric condition to identify a set of changes attributable to the neuropsychiatric therapy; generating, using the processor, a mechanism of action for the neuropsychiatric therapy for the plurality of human subjects diagnosed with the given neuropsychiatric condition based on the analyzing of the set of changes for the each human subject, wherein the mechanism of action comprises a set of links to the portions of the medical literature associated with the neuropsychiatric therapy and each change in the set of changes identified from an automatic searching of the set of online electronic medical literature sources; generating, using the processor, the set of links to the portions of the medical literature associated with the neuropsychiatric therapy used to treat the given neuropsychiatric condition; and embedding, using the processor, the set of links to the portions of the medical literature associated with the neuropsychiatric therapy used to treat the given neuropsychiatric condition within the first set of regions of interest located in the first set of human brain scans for the each human subject in the plurality of human subjects diagnosed with the given neuropsychiatric condition and the second set of regions of interest located in the second set of human brain scans for the each human subject in the plurality of human subjects diagnosed with the given neuropsychiatric condition. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. A non-transitory computer readable storage medium having computer usable program code for assessing neuroimaging and medical data to determine mechanisms of action for neuropsychiatric therapies embodied therewith that is executable by a computer, the computer usable program code comprising:
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computer usable program code configured to receive via a network connection neuroimaging data of a first set of human brain scans for each human subject in a plurality of human subjects diagnosed with a given neuropsychiatric condition generated at a first time period prior to beginning implementation of a neuropsychiatric therapy to treat the given neuropsychiatric condition and a second set of human brain scans for the each human subject in the plurality of human subjects diagnosed with the given neuropsychiatric condition generated at a second time period of a given amount of time after beginning the implementation of the neuropsychiatric therapy to treat the given neuropsychiatric condition, wherein a set of one or more scanning devices generate the neuroimaging data of the first set of human brain scans and the second set of human brain scans, and wherein the neuropsychiatric therapy is received by the each human subject in the plurality of human subjects diagnosed with the given neuropsychiatric condition; computer usable program code configured to automatically search via the network connection a set of online electronic medical literature sources for portions of medical literature describing the neuropsychiatric therapy used to treat the given neuropsychiatric condition; computer usable program code configured to automatically select a first set of regions of interest in the first set of human brain scans for the each human subject in the plurality of human subjects diagnosed with the given neuropsychiatric condition generated at the first time period prior to beginning the implementation of the neuropsychiatric therapy to treat the given neuropsychiatric condition and a second set of regions of interest in the second set of human brain scans for the each human subject in the plurality of human subjects diagnosed with the given neuropsychiatric condition generated at the second time period of the given amount of time after beginning the implementation of the neuropsychiatric therapy to treat the given neuropsychiatric condition; computer usable program code configured to identify a set of changes in the neuroimaging data of the first set of human brain scans and the second set of human brain scans for the each human subject in the plurality of human subjects diagnosed with the given neuropsychiatric condition based on a comparison of the first set of regions of interest for the each human subject with the second set of regions of interest for the each human subject, wherein the set of changes comprises indicators of change occurring after the each human subject began receiving the neuropsychiatric therapy to treat the given neuropsychiatric condition; computer usable program code configured to analyze the set of changes for the each human subject with the portions of the medical literature describing the neuropsychiatric therapy used to treat the given neuropsychiatric condition to identify a set of changes attributable to the neuropsychiatric therapy; computer usable program code configured to generate a mechanism of action for the neuropsychiatric therapy for the plurality of human subjects diagnosed with the given neuropsychiatric condition based on the analyzing of the set of changes for the each human subject, wherein the mechanism of action comprises a set of links to the portions of the medical literature associated with the neuropsychiatric therapy and each change in the set of changes identified from an automatic searching of the set of online electronic medical literature sources; computer usable program code configured to generate the set of links to the portions of the medical literature associated with the neuropsychiatric therapy used to treat the given neuropsychiatric condition; and computer usable program code configured to embed the set of links to the portions of the medical literature associated with the neuropsychiatric therapy used to treat the given neuropsychiatric condition within the first set of regions of interest located in the first set of human brain scans for the each human subject in the plurality of human subjects diagnosed with the given neuropsychiatric condition and the second set of regions of interest located in the second set of human brain scans for the each human subject in the plurality of human subjects diagnosed with the given neuropsychiatric condition. - View Dependent Claims (11, 12, 13, 14, 15, 16)
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17. An apparatus for assessing neuroimaging and medical data to determine mechanisms of action for neuropsychiatric therapies comprising:
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a bus system; a communications system coupled to the bus system; a non-transitory computer readable storage medium connected to the bus system, wherein the non-transitory computer readable storage medium stores computer usable program code; and a processor chip coupled to the bus system, wherein the processor chip executes the computer usable program code to; receive via a network connection neuroimaging data of a first set of human brain scans for each human subject in a plurality of human subjects diagnosed with a given neuropsychiatric condition generated at a first time period prior to beginning implementation of a neuropsychiatric therapy to treat the given neuropsychiatric condition and a second set of human brain scans for the each human subject in the plurality of human subjects diagnosed with the given neuropsychiatric condition generated at a second time period of a given amount of time after beginning the implementation of the neuropsychiatric therapy to treat the given neuropsychiatric condition, wherein a set of one or more scanning devices generate the neuroimaging data of the first set of human brain scans and the second set of human brain scans, and wherein the neuropsychiatric therapy is received by the each human subject in the plurality of human subjects diagnosed with the given neuropsychiatric condition; automatically search via the network connection a set of online electronic medical literature sources for portions of medical literature describing the neuropsychiatric therapy used to treat the given neuropsychiatric condition; analyze the first set of brain scans and the second set of brain scans to identify a first set of regions of interest in the first set of human brain scans for the each human subject in the plurality of human subjects diagnosed with the given neuropsychiatric condition generated at the first time period prior to beginning the implementation of the neuropsychiatric therapy to treat the given neuropsychiatric condition and a second set of regions of interest in the second set of human brain scans for the each human subject in the plurality of human subjects diagnosed with the given neuropsychiatric condition generated at the second time period of the given amount of time after beginning the implementation of the neuropsychiatric therapy to treat the given neuropsychiatric condition; identify a set of changes in the neuroimaging data of the first set of human brain scans and the second set of human brain scans for the each human subject in the plurality of human subjects diagnosed with the given neuropsychiatric condition based on a comparison of the first set of regions of interest for the each human subject with the second set of regions of interest for the each human subject, wherein the set of changes comprises indicators of change occurring after the each human subject began receiving the neuropsychiatric therapy to treat the given neuropsychiatric condition; analyze the set of changes for the each human subject with the portions of the medical literature describing the neuropsychiatric therapy used to treat the given neuropsychiatric condition to identify a set of changes attributable to the neuropsychiatric therapy; generate the set of links to the portions of the medical literature associated with the neuropsychiatric therapy used to treat the given neuropsychiatric condition; and embed the set of links to the portions of the medical literature associated with the neuropsychiatric therapy used to treat the given neuropsychiatric condition within the first set of regions of interest located in the first set of human brain scans for the each human subject in the plurality of human subjects diagnosed with the given neuropsychiatric condition and the second set of regions of interest located in the second set of human brain scans for the each human subject in the plurality of human subjects diagnosed with the given neuropsychiatric condition. - View Dependent Claims (18, 19)
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20. A data processing system for assessing neuroimaging and medical data to determine mechanisms of action for neuropsychiatric therapies comprising:
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a set of online electronic medical literature sources, wherein the set of online medical literature sources comprises medical literature; a neuroimage mapping manager, wherein the neuroimage mapping manager automatically retrieves via a network connection portions of the medical literature that describe a neuropsychiatric therapy from the set of online electronic medical literature sources;
analyzes neuroimaging data corresponding to a plurality of human brain scans for a plurality of human subjects diagnosed with a given neuropsychiatric condition who receive the neuropsychiatric therapy to identify a first set of regions of interest in a first set of human brain scans for each human subject in the plurality of human subjects diagnosed with the given neuropsychiatric condition and a second set of regions of interest in a second set of human brain scans for each human subject in the plurality of human subjects diagnosed with the given neuropsychiatric condition and identifies a set of changes in the neuroimaging data of the first set of human brain scans and the second set of human brain scans for each human subject in the plurality of human subjects diagnosed with the given neuropsychiatric condition based on a comparison of the first set of regions of interest for each human subject with the second set of regions of interest for each human subject, wherein the first set of brain scans for each human subject in the plurality of human subjects diagnosed with the given neuropsychiatric condition is generated at a first time period prior to beginning implementation of the neuropsychiatric therapy to treat the given neuropsychiatric condition and the second set of human brain scans for each human subject in the plurality of human subjects diagnosed with the given neuropsychiatric condition is generated at a second time period of a given amount of time after beginning the implementation of the neuropsychiatric therapy to treat the given neuropsychiatric condition, and wherein a set of one or more scanning devices generate the neuroimaging data of the first set of human brain scans and the second set of human brain scans, and wherein the neuropsychiatric therapy is administered to each human subject in the plurality of human subjects diagnosed with the given neuropsychiatric condition, and wherein the set of changes identified in the first set of human brain scans and the second set of human brain scans for each human subject in the plurality of human subjects diagnosed with the given neuropsychiatric condition is changes that occur after each human subject began to receive the neuropsychiatric therapy; anda therapy mechanism generator, wherein the therapy mechanism generator analyzes the set of changes for each human subject with the portions of the medical literature that describe the neuropsychiatric therapy used to treat the given neuropsychiatric condition to identify a set of changes attributable to the neuropsychiatric therapy;
generates a mechanism of action for the neuropsychiatric therapy based on the set of changes, wherein the mechanism of action comprises a set of links to the portions of the medical literature associated with the neuropsychiatric therapy and each change in the set of changes identified from an automatic searching of the set of online electronic medical literature sources;
generates the set of links to the portions of the medical literature associated with the neuropsychiatric therapy used to treat the given neuropsychiatric condition; and
embeds the set of links to the portions of the medical literature associated with the neuropsychiatric therapy used to treat the given neuropsychiatric condition within the first set of regions of interest located in the first set of human brain scans for the each human subject in the plurality of human subjects diagnosed with the given neuropsychiatric condition and the second set of regions of interest located in the second set of human brain scans for the each human subject in the plurality of human subjects diagnosed with the given neuropsychiatric condition. - View Dependent Claims (21, 22)
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Specification