Metrics of electrical dyssynchrony and electrical activation patterns from surface ECG electrodes

• US 9,486,151 B2
• Filed: 02/26/2014
• Issued: 11/08/2016
• Est. Priority Date: 06/12/2013
• Status: Active Grant

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Ghosh, Subham, Gillberg, Jeffrey M
• Primary Examiner(s): EVANISKO, GEORGE ROBERT
• Application Number:
  US14/190,508
• Publication Number:
  US 20140371807A1
• Time in Patent Office: 986 Days
• US Class Current: 1/1
• CPC Class Codes: A61B 5/282 Holders for multiple electrodes for introduction into the body A61B5/287
• CPC Class Codes: A61B 5/349 Detecting specific parameters of the electrocardiograph cycle
• CPC Class Codes: A61B 5/353 Detecting P-waves
• CPC Class Codes: A61B 5/355 Detecting T-waves
• CPC Class Codes: A61B 5/6805 Vests
• CPC Class Codes: A61B 5/7282 Event detection, e.g. detecting unique waveforms indicative of a medical condition A61B5/4094, A61B5/4818, A61B5/349, A61B5/0823 take precedence
• CPC Class Codes: A61N 1/3627 for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy
• CPC Class Codes: A61N 1/3682 with a variable atrioventricular delay
• CPC Class Codes: A61N 1/3684 for stimulating the heart at multiple sites of the ventricle or the atrium
• CPC Class Codes: A61N 1/36842 Multi-site stimulation in the same chamber
• CPC Class Codes: A61N 1/36843 Bi-ventricular stimulation

Abstract

A method and system of cardiac pacing is disclosed. A baseline rhythm is determined using a plurality of body-surface electrodes. A set of baseline functional electrical metrics is determined in response to determining the baseline rhythm. Resynchronization pacing is delivered using a right ventricular electrode and a pacing left ventricular electrode or only with a left ventricular electrode. A set of functional electrical metrics relating to cardiac depolarization and repolarization is determined in response to resynchronization pacing. A determination is made as to whether relative reduction of at least one functional electrical metric from the set of functional electrical metrics exceeds X % of its corresponding value from the set of baseline functional electrical metrics. A determination is made as to whether an absolute value of at least one electrical metric from the set of the functional electrical metrics is less than Y ms. A determination is made as to whether a site is responsive to cardiac resynchronization therapy (CRT).

Claims

1. A method of cardiac pacing comprising:

(a) determining a baseline rhythm using a plurality of body-surface electrodes;

(b) determining a set of baseline functional electrical metrics in response to determining the baseline rhythm;

(c) delivering resynchronization pacing using a right ventricular electrode and a left ventricular electrode or delivering the resynchronization pacing using only a left ventricular electrode;

(d) determining a set of functional electrical metrics relating to cardiac depolarization and repolarization in response to resynchronization pacing;

(e) determining whether relative reduction of at least one functional electrical metric from the set of functional electrical metrics in step d exceeds X % of its corresponding value from the set of baseline functional electrical metrics in step (b);

(f) determining whether an absolute value of at least one electrical metric from the set of the functional electrical metrics in step (d) is less than Y ms; and

(g) determining that a site is responsive to cardiac resynchronization therapy (CRT) in response to determining whether steps (e) or (f) are met.

2. The method of claim 1 wherein the baseline functional electrical metrics includes an intrinsic atrioventricular (iAV) delay.

3. The method of claim 2 wherein resynchronization pacing is delivered using a set of AV delays.

4. The method of claim 3 wherein the resynchronization pacing is delivered using a first AV delay, the first AV delay comprising a sensed AV (SAV) interval or a paced AV (PAV) interval, the SAV or the PAV is equal to the greater of an intrinsic iAV-60 ms and 80 ms.

5. The method of claim 4 wherein the resynchronization pacing is delivered using a second AV delay, the second AV delay comprising a SAV interval or a PAV interval being set at one of iAV-30 ms and iAV-90 ms.

6. The method of claim 5 wherein the resynchronization pacing is delivered using a third AV delay, the third AV delay being set at one of IAV-30 ms and iAV-90 ms.

7. The method of claim 5, wherein the second AV delay uses the SAV interval provided the first AV delay used the SAV interval.

8. The method of claim 5, wherein the second AV delay uses the PAV interval provided the first AV delay used the PAV interval.

9. The method of claim 5, wherein the second AV delay uses the PAV interval while the first AV delay used the SAV interval.

10. The method of claim 3 wherein the set of AV delays are employed to confirm response or non-response.

11. The method of claim 3 wherein selection of an AV delay is dependent upon AV delay values near the intrinsic AV delay (iAV).

12. The method of claim 3 wherein AV delay values near the iAV includes AV delays greater than or equal to (iAV-30 ms or iAV-90 ms), 80 ms.

13. The method of claim 1 wherein the functional electrical metrics are indicative of electrical dyssynchrony during a cardiac depolarization process and dispersion of repolarization during a cardiac repolarization process.

14. The method of claim 1 wherein the functional electrical metrics are associated with at least one resynchronization of activation metric.

15. The method of claim 14 wherein the resynchronization of activation metric relates to dispersion of electrical activation times corresponding to a plurality of the body-surface electrodes on a torso or on certain predefined anatomic areas of the torso.

16. The method of claim 15 wherein at least one resynchronization of activation metric is standard deviation of activation times acquired from all the torso electrodes.

17. The method of claim 15 wherein at least one resynchronization of activation metric is standard deviation of activation times of only left-sided electrodes of the torso electrodes.

18. The method of claim 14 wherein at least one resynchronization of activation metric is associated with central tendency of electrical activation times corresponding to a plurality of the body-surface electrodes on a torso or on certain predefined anatomic areas of the torso.

19. The method of claim 18 wherein the central tendency of electrical activation times reflects one of an average global activation time and an average regional activation time.

20. The method of claim 1, wherein X % ranges from about 5% to about 100%.

21. The method of claim 1, wherein Y ranges from about 15 ms to about 150 ms.

22. The method of claim 1 further comprising:

selecting an optimal site to locate a lead.

23. The method of claim 1 wherein the functional electrical metrics comprise a measure of dispersion, and further wherein the measure of dispersion includes standard deviation, range or interquartile deviation of activation times, repolarization times, activation-recovery intervals associated with a plurality of the body-surface electrodes.

24. The method of claim 1, wherein the functional electrical metrics comprise a central tendency, and further wherein the central tendency is one of a mean, a median, mode or a sum of absolute values of activation times associated with a plurality of the body-surface electrodes.

25. The method of claim 1, wherein the method further comprises determining a non-responsive site as one which does not satisfy step (g) for resynchronization pacing delivered at any of a set of AV delays separated from each other by at least 20 ms.

26. The method of claim 1, wherein delivering resynchronization pacing and determining a set of functional electrical metrics comprises:

delivering resvnchronization pacing using a first LV pacing electrode and a second LV pacing electrode; and

determining a first and second functional electrical metric of the set of functional electrical metrics relating to cardiac depolarization and repolarization in response to the resynchronization pacing using each of the first LV pacing electrode and the second LV pacing electrode, the method further comprising;

determining the first LV pacing electrode and the second LV pacing electrode are equivalently responsive based upon the first functional electrical metric determined in response to the resynchronization pacing using each of the first LV pacing electrode and the second LV pacing electrode; and

selecting one of the first LV electrode and the second LV electrode as an optimal electrode from which to pace in response to generating data based upon the second functional electrical metric determined in response to the resynchronization pacing using each of the first LV pacing electrode and the second LV pacing electrode.

27. A method of cardiac pacing comprising:

(a) determining a baseline rhythm using a plurality of body-surface electrodes;

(b) determining a set of baseline functional electrical metrics in response to determining the baseline rhythm;

(c) delivering resynchronization pacing using a right ventricular electrode and a pacing left ventricular electrode or delivering resynchronization pacing using only a left ventricular electrode;

(d) determining a set of functional electrical metrics relating to cardiac depolarization and repolarization in response to resynchronization pacing;

(e) determining whether relative reduction of a first functional electrical metric from the set of functional electrical metrics in step (d) exceeds X % of a first electrical functional metric from the set of baseline functional electrical metrics in step (b);

(f) determining whether an absolute value of a second functional electrical metric from the set of the functional electrical metrics is less than Y ms; and

(g) determining that a site is responsive to CRT in response to determining whether steps (e) and (f) are met.

28. The method of claim 27, wherein X % ranges from about 5% ms to about 100% ms.

29. The method of claim 27, wherein Y ranges from about 15 ms to about 150 ms.

30. A system of cardiac pacing comprising:

a plurality of body-surface electrodes;

means for determining a baseline rhythm using the plurality of body-surface electrodes;

means for determining a set of baseline functional electrical metrics in response to determining the baseline rhythm;

at least one of a right ventricular electrode and a pacing left ventricular electrode;

delivering means for delivering resynchronization pacing using the right ventricular electrode and the pacing left ventricular electrode or delivering means for delivering resynchronization pacing using only the left ventricular electrode;

means for determining a set of functional electrical metrics relating to cardiac depolarization and repolarization in response to resynchronization pacing;

means for determining whether relative reduction of a first functional electrical metric from the set of functional electrical metrics exceeds X % of a first electrical functional metric from the set of baseline functional electrical metrics;

means for determining whether an absolute value of a second functional electrical metric from the set of the functional electrical metrics is less than Y ms; and

means for determining that a site is responsive to CRT in response to determining whether the relative reduction of the first functional electrical metric from the set of functional electrical metrics exceeds X % of the first electrical functional metric from the set of baseline functional electrical metrics and whether the absolute value of the second functional electrical metric from the set of the functional electrical metrics is less than Y ms.

31. The system of claim 30, wherein X % ranges from about 5% ms to about 100% ms.

32. The system of claim 30, wherein Y ranges from about 15 ms to about 150 ms.

33. The system of claim 30 wherein the baseline functional electrical metrics includes an atrioventricular (iAV) delay.

34. The system of claim 33 wherein the resynchronization pacing is delivered using a set of AV delays.

35. The system of claim 34 wherein the resynchronization pacing is delivered using a first AV delay, the first AV delay comprising a sensed AV (SAV) interval or a paced AV (PAV) interval, the SAV or the PAV is equal to the greater of an intrinsic iAV-60 ms and 80 ms.

36. The system of claim 35 wherein the resynchronization pacing is delivered using a second AV delay, the second AV delay comprising a SAV interval or a PAV interval being set at one of iAV-30 ms and iAV-90 ms.

37. The system of claim 36 wherein the resynchronization pacing is delivered using a third AV delay, the third AV delay being set at one of iAV-30 ms and iAV-90 ms.

38. The system of claim 34 wherein the set of AV delays are employed to confirm response or non-response to CRT pacing.

39. The system of claim 38 wherein selection of an AV delay is dependent upon the set of AV delay values near the iAV delay.

40. The system of claim 39 wherein AV delay values near the iAV includes AV delays greater than or equal to (iAV-30 ms or iAV-90 ms), 80 ms.