Use of cellular extracts for skin rejuvenation

• US 9,486,401 B2
• Filed: 12/22/2014
• Issued: 11/08/2016
• Est. Priority Date: 05/11/2006
• Status: Active Grant

• Current Assignee: Regenics AS
• Original Assignee: Regenics AS
• Inventors: Gammelsaeter, Runhild, Remmereit, Jan
• Primary Examiner(s): Bertoglio, Valarie
• Application Number:
  US14/578,923
• Publication Number:
  US 20150110892A1
• Time in Patent Office: 687 Days
• US Class Current: 1/1
• CPC Class Codes: A61K 35/60 Fish, e.g. seahorses; Fish eggs
• CPC Class Codes: A61K 8/676 Ascorbic acid, i.e. vitamin C
• CPC Class Codes: A61K 8/982 Reproductive organs; Embryos, Eggs
• CPC Class Codes: A61K 8/987 of species other than mammals or birds
• CPC Class Codes: A61Q 19/00 Preparations for care of the skin
• CPC Class Codes: A61Q 19/02 for chemically bleaching or whitening the skin
• CPC Class Codes: A61Q 19/08 Anti-ageing preparations
• CPC Class Codes: A61Q 7/00 Preparations for affecting hair growth

Abstract

The invention describes methods and agents for improving cosmetic appearance, for promoting, improving or restoring health of cells and tissues, preferably skin, and more preferably, for restoring aged or damaged skin to a healthy appearance. In preferred embodiments, the methods and agents comprise active extracts produced from fish eggs. The invention further provides processes for making active fish egg extracts.

Claims

1. A process for producing a biologically active salmon egg fraction comprising:

treating unfertilized salmon eggs to reduce bacterial load;

homogenizing said unfertilized salmon eggs by application of pressure to produce a salmon egg homogenate;

separating a fraction from said unfertilized salmon egg homogenate by centrifugation to provide said biologically active salmon egg fraction, wherein said biologically active fraction comprises about 100 to 380 mg/ml protein in an aqueous solution.

2. The process of claim 1, wherein said pressure is hydraulic pressure.

3. The process of claim 2, wherein said hydraulic pressure is applied via a hydropress.

4. The process of claim 1, further comprising the step of freeze-drying said active fraction.

5. The process of claim 1, further comprising formulating said active fraction for oral administration.

6. The process of claim 1, further comprising combining said active fraction with a lipid.

7. The process of claim 1, further comprising combining said active fraction with a natural marine-derived fat-soluble vitamin.

8. The process of claim 1, further comprising combining said active fraction with a natural or synthetic protein.

9. The process of claim 1, wherein said centrifugation is continuous.