Method for delivering liraglutide preparations into a lumen of the intestinal tract using a swallowable drug delivery device
First Claim
1. A method for delivering Liraglutide to a patient, said method comprising:
- providing an oral solid Liraglutide dosage shaped as a tissue penetrating member having a pointed tip, the tissue penetrating member configured to be carried by a swallowable capsule and penetrate and be inserted into an intestinal wall, wherein upon ingestion, the capsule advances to the small intestine of the patient; and
delivering the solid Liraglutide dosage into the wall of the small intestine by an application of mechanical force upon a surface of the tissue penetrating member from an expandable member operably coupled to the tissue penetrating member wherein upon insertion into the intestinal wall, the tissue penetrating member remains to release Liraglutide into the blood stream from the intestinal wall by degradation of the of the tissue penetrating member.
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Accused Products
Abstract
Embodiments of the invention provide swallowable devices, preparations and methods for delivering drugs and other therapeutic agents within the GI tract. Many embodiments provide a swallowable device for delivering the agents. Particular embodiments provide a swallowable device such as a capsule for delivering drugs into the intestinal wall or other GI lumen. Embodiments also provide various drug preparations that are configured to be contained within the capsule, advanced from the capsule into the intestinal wall and degrade to release the drug into the bloodstream to produce a therapeutic effect. The preparation can be operably coupled to delivery means having a first configuration where the preparation is contained in the capsule and a second configuration where the preparation is advanced out of the capsule into the intestinal wall. Embodiments of the invention are particularly useful for the delivery of drugs which are poorly absorbed, tolerated and/or degraded within the GI tract.
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Citations
21 Claims
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1. A method for delivering Liraglutide to a patient, said method comprising:
- providing an oral solid Liraglutide dosage shaped as a tissue penetrating member having a pointed tip, the tissue penetrating member configured to be carried by a swallowable capsule and penetrate and be inserted into an intestinal wall, wherein upon ingestion, the capsule advances to the small intestine of the patient; and
delivering the solid Liraglutide dosage into the wall of the small intestine by an application of mechanical force upon a surface of the tissue penetrating member from an expandable member operably coupled to the tissue penetrating member wherein upon insertion into the intestinal wall, the tissue penetrating member remains to release Liraglutide into the blood stream from the intestinal wall by degradation of the of the tissue penetrating member. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18)
- providing an oral solid Liraglutide dosage shaped as a tissue penetrating member having a pointed tip, the tissue penetrating member configured to be carried by a swallowable capsule and penetrate and be inserted into an intestinal wall, wherein upon ingestion, the capsule advances to the small intestine of the patient; and
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19. A method for delivering Liraglutide to a patient, said method comprising:
- providing a solid Liraglutide dosage in a penetrating form within a swallowable capsule having at least one tissue penetrating member having a lumen;
delivering the Liraglutide dosage into a wall of the small intestine from the capsule via the tissue penetrating member lumen and an application of mechanical force on the solid Liraglutide dosage, the delivery of the Liraglutide being effectuated responsive to a condition unique to the small intestine, and wherein the Liraglutide is released into the blood stream from the dosage of Liraglutide in the wall of the small intestine. - View Dependent Claims (20, 21)
- providing a solid Liraglutide dosage in a penetrating form within a swallowable capsule having at least one tissue penetrating member having a lumen;
Specification