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Composition and method for treatment of depression and psychosis in humans

  • US 9,486,453 B2
  • Filed: 09/03/2015
  • Issued: 11/08/2016
  • Est. Priority Date: 07/12/2012
  • Status: Active Grant
First Claim
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1. A method for reducing akathisia caused by lurasidone treatment in a subject with bipolar disorder, comprising:

  • administering an akathisia-inducing amount of lurasidone to the subject;

    once akathisia is induced, continuing to administer lurasidone at a same dosage and frequency that caused akathisia; and

    administering a therapeutically effective amount of a second composition comprising D-cycloserine (DCS) at a dosage in excess of 500 mg/day, wherein the DCS produces a NMDA receptor antagonistic blood plasma concentration measured at greater than 25 micrograms/mL,thereby reducing akathisia.

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