Regulation of food preference using GLP-1 agonists
First Claim
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1. A method for shifting food preference in a subject with an abnormal or excessive intake of food, comprisingadministering to the subject an effective amount of Arg34, Lys26(Nε
- -(γ
-Glu(Nε
-hexadecanoyl)))-GLP-1(7-37);
wherein the subject is obese and has a BMI greater than 25;
wherein the abnormal or excessive intake of food is of a first food comprising a glycemic index above 40%, wherein more than 30% of the total energy in said first food stems from fat, and a second food comprising mono- and di-saccharides that together constitute more than 50% of the total amount of carbohydrate in said second food; and
wherein the food preference is shifted away from the first food and the second food.
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Abstract
GLP-1 agonists selectively decrease the amount of food intake, wherein the food has a high glycemic index or wherein the amount of mono- and di-saccharides together constitute a large proportion of the total amount of carbohydrates.
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2 Claims
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1. A method for shifting food preference in a subject with an abnormal or excessive intake of food, comprising
administering to the subject an effective amount of Arg34, Lys26(Nε - -(γ
-Glu(Nε
-hexadecanoyl)))-GLP-1(7-37);wherein the subject is obese and has a BMI greater than 25; wherein the abnormal or excessive intake of food is of a first food comprising a glycemic index above 40%, wherein more than 30% of the total energy in said first food stems from fat, and a second food comprising mono- and di-saccharides that together constitute more than 50% of the total amount of carbohydrate in said second food; and wherein the food preference is shifted away from the first food and the second food. - View Dependent Claims (2)
- -(γ
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