Treatment for diabetes in patients inappropriate for metformin therapy
DCFirst Claim
1. A method for treating and/or preventing type 2 diabetes mellitus in a patient having moderate or severe chronic renal impairment or end-stage renal disease comprising orally administering to the patient a DPP-4 inhibitor, which is 1-[(4-methyl-quinazolin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8-(3-(R)-amino-piperidin-1-yl)-xanthine or a pharmaceutically acceptable salt thereof, wherein said DPP-4 inhibitor is administered in an oral dose of 5 mg per day to said patient, wherein metformin therapy for said patient is ineligible due to contraindication against metformin.
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Abstract
The present invention relates to the finding that certain DPP-4 inhibitors are particularly suitable for treating and/or preventing metabolic diseases, particularly diabetes, in patients for whom metformin therapy is inappropriate due to intolerability or contraindication against metformin.
312 Citations
14 Claims
- 1. A method for treating and/or preventing type 2 diabetes mellitus in a patient having moderate or severe chronic renal impairment or end-stage renal disease comprising orally administering to the patient a DPP-4 inhibitor, which is 1-[(4-methyl-quinazolin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8-(3-(R)-amino-piperidin-1-yl)-xanthine or a pharmaceutically acceptable salt thereof, wherein said DPP-4 inhibitor is administered in an oral dose of 5 mg per day to said patient, wherein metformin therapy for said patient is ineligible due to contraindication against metformin.
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8. A method for treating type 2 diabetes mellitus in a patient with severe chronic renal impairment and for whom metformin therapy is ineligible due to contraindication against metformin, comprising orally administering to the patient a DPP-4 inhibitor which is 1-[(4-methyl-quinazolin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8-(3-(R)-amino-piperidin-1-yl)-xanthine in a dose of 5 mg.
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9. A method for treating type 2 diabetes mellitus in a patient with severe chronic renal impairment and who is ineligible for metformin therapy due to contraindication against metformin, comprising orally administering to the patient a DPP-4 inhibitor which is 1-[(4-methyl-quinazolin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8-(3-(R)-amino-piperidin-1-yl)-xanthine in a dose of 5 mg, wherein said DPP-4 inhibitor is used for said patient in the same dose as for a patient with normal renal function.
- 10. A method for treating type 2 diabetes mellitus in a patient having chronic renal insufficiency or chronic renal impairment of moderate, severe or terminal stage, comprising orally administering to the patient a DPP-4 inhibitor which is 1-[(4-methyl-quinazolin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8-(3-(R)-amino-piperidin-1-yl)-xanthine in a dose of 5 mg once daily, wherein metformin therapy for said patient is ineligible due to contraindication against metformin.
- 13. A method of treating a type 2 diabetic patient with severe chronic renal impairment and for whom metformin therapy is ineligible due to contraindication against metformin comprising orally administering 5 mg of 1-[(4-methyl-quinazolin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8-(3-(R)-amino-piperidin-1-yl)-xanthine to the patient, wherein the patient may be on insulin and/or sulfonylurea background medication.
Specification