Prefilled syringe with breakaway force feature

• US 9,486,583 B2
• Filed: 03/05/2013
• Issued: 11/08/2016
• Est. Priority Date: 03/06/2012
• Status: Active Grant

• Current Assignee: Antares Pharma Incorporated
• Original Assignee: Antares Pharma Incorporated
• Inventors: Lannan, James W., Sund, Julius C.
• Primary Examiner(s): Price, Nathan R
• Assistant Examiner(s): LEE, WENG WAH
• Application Number:
  US13/785,582
• Publication Number:
  US 20130237921A1
• Time in Patent Office: 1,344 Days
• Field of Search: 604/131, 604135-138, 604/187
• US Class Current: 1/1
• CPC Class Codes: A61M 2005/2013 triggering of discharging means by contact of injector with patient body
• CPC Class Codes: A61M 2005/2073 preventing premature release, e.g. by making use of a safety lock
• CPC Class Codes: A61M 2005/3267 Biased sleeves where the needle is uncovered by insertion of the needle into a patient's body
• CPC Class Codes: A61M 5/2033 Spring-loaded one-shot injectors with or without automatic needle insertion multishot dosing syringes A61M5/31525, needle insertion only A61M5/3287
• CPC Class Codes: A61M 5/50 having means for preventing re-use, or for indicating if defective, used, tampered with or unsterile retractable needles or needle protectors with means for preventing re-use A61M5/321

Abstract

A jet injector that includes a prefilled syringe. The syringe includes a fluid chamber that contains a medicament. The syringe also has an injection-assisting needle, and a plunger is movable within the fluid chamber. A housing is configured for allowing insertion of the needle to a penetration depth. The housing includes a retractable guard and an interference component, e.g., a lock ring, adjacent to the retractable guard that interferes with the movement of the retractable guard. An energy source is configured for biasing the plunger to produce an injecting pressure to jet inject the medicament from the fluid chamber through the needle to an injection site.

Claims

1. A jet injector, comprising:

a prefilled syringe comprising;

a container portion defining a fluid chamber containing a medicament and defining a longitudinal axis therethrough;

an injection-assisting needle disposed at the distal end of the chamber, having an injecting tip configured for piercing an insertion location, and defining a fluid pathway in fluid communication with the chamber for injecting the fluid from the chamber into an injection site;

a plunger movable within the fluid chamber;

a housing that houses the prefilled syringe and is configured for allowing insertion of the needle at the injection location to an insertion point that is at a penetration depth below the surface, the housing comprising;

a retractable guard that is movable between a protecting position in which the needle is disposed within the guard and an injecting position in which the tip of the needle is exposed for insertion to the insertion point, and

an interference component adjacent to the retractable guard, the interference component being a ring having at least one abutment arm, the abutment arm having at least one tapered portion and an engagement portion axially adjacent to the at least one tapered portion, the engagement portion comprising a surface angled relative to an incline of the tapered portion, the angled surface of the engagement portion extending radially outward relative to the longitudinal axis and from a proximal end of the tapered portion and is configured to block and cause resistance to the movement of the retractable guard when the retractable guard is moved at least partially from the protecting position toward the injecting position;

a syringe support supportively mounting the prefilled syringe in the housing;

an energy source configured for biasing the plunger with a force selected to produce an injecting pressure on the medicament in the fluid chamber to jet inject the medicament from the fluid chamber through the needle to the injection site.

2. The jet injector of claim 1, wherein the energy source and prefilled syringe are configured such that the injecting pressure remains between about 80 p.s.i. and about 1000 p.s.i. during injection of the medicament.

3. The jet injector of claim 2, wherein the energy source and prefilled syringe are configured such that the injecting pressure remains below about 500 p.s.i. and above about 90 p.s.i. during the injection of the medicament.

4. The jet injector of claim 2, wherein the energy source and prefilled syringe are configured to produce the injecting pressure that remains at least at about 100 p.s.i. during the injection of the medicament.

5. The jet injector of claim 4, wherein the energy source and prefilled syringe are configured such that the injecting pressure remains up to about 350 p.s.i. during the injection of the medicament.

6. The jet injector of claim 1, wherein the prefilled syringe has a distal portion in which the injection-assisting needle is located, and a proximal portion opposite the distal portion;

and the syringe support axially supports the proximal portion of the pre-filled syringe during the jet injection of the medicament, such that the distal portion of the prefilled syringe is substantially unsupported in an axial direction.

7. The jet injector of claim 6, wherein the container portion of the pre-filled syringe is made of blown glass.

8. The jet injector of claim 7, wherein the injection-assisting needle is adhered to the glass.

9. The jet injector of claim 1, wherein the ring is dimensioned to fit within the housing.

10. The jet injector of claim 1, wherein the energy source comprises a spring.

11. The jet injector of claim 10, further comprising a ram that is biased by the spring against the plunger to produce the injecting pressure, wherein the ram comprises a bell portion on which the spring is seated, and the bell portion defines a hollow interior configured for receiving the prefilled syringe when the device is fired, such that the spring surrounds the prefilled syringe.

12. The jet injector of claim 1, further comprising a trigger mechanism operably associated with the energy source for activating the energy source to jet inject the medicament, wherein the trigger mechanism is configured for activating the energy source after the retractable guard is retracted from the protecting position.

13. The jet injector of claim 12, wherein the retractable guard is operably associated with the trigger mechanism to cause the trigger mechanism to activate the energy source when the guard is retracted to the injecting position.

14. The jet injector of claim 1, wherein the interference component is a sleeve having an engagement portion extending outwardly from an outer surface of the sleeve that is configured to cause resistance to the movement of the retractable guard when the retractable guard is moved at least partially from the protecting position toward the injecting position.

15. The jet injector of claim 1, wherein the interference component is a latch coupled to the housing that is configured to cause resistance to the movement of the retractable guard when the retractable guard is moved at least partially from the protecting position toward the injecting position.

16. The jet injector of claim 1, wherein the housing is configured for allowing insertion of the needle to the penetration depth, which is between about 0.5 mm and about 5 mm below the surface at the insertion location.

17. The jet injector of claim 1, wherein the housing is configured for allowing insertion of the needle to the penetration depth, which is between about 11 mm and about 13 mm below the surface at the insertion location.

18. The jet injector of claim 1, wherein the chamber contains about between 0.02 mL and about 4 mL of the medicament.

19. The jet injector of claim 1, wherein the penetration depth and injecting pressure are sufficient to substantially prevent backflow of the injected medicament.

20. The jet injector of claim 1, further comprising a syringe cushion associated with the syringe support and prefilled syringe to compensate for shape irregularities of the pre-filled syringe.

21. A jet injector, comprising:

a prefilled syringe comprising;

a container portion defining a fluid chamber containing a medicament and defining a longitudinal axis therethrough;

an injection-assisting needle disposed at the distal end of the chamber, having an injecting tip configured for piercing an insertion location, and defining a fluid pathway in fluid communication with the chamber for injecting the fluid from the chamber into an injection site;

a plunger movable within the fluid chamber;

a housing that houses the prefilled syringe and is configured for allowing insertion of the needle at the injection location to an insertion point that is at a penetration depth below the surface, the housing comprising;

a retractable guard that is movable between a protecting position in which the needle is disposed within the guard and an injecting position in which the tip of the needle is exposed for insertion to the insertion point, and

an interference component adjacent to the retractable guard, the interference component having at least one abutment arm, the abutment arm having at least one tapered portion and an engagement portion axially adjacent to the at least one tapered portion, the engagement portion comprising a surface angled relative to an incline of the tapered portion, the angled surface of the engagement portion extending radially outward relative to the longitudinal axis and from a proximal end of the tapered portion and is configured to block and cause resistance to the movement of the retractable guard when the retractable guard is moved at least partially from the protecting position toward the injecting position;

a syringe support supportively mounting the prefilled syringe in the housing;

an energy source configured for biasing the plunger with a force selected to produce an injecting pressure on the medicament in the fluid chamber to jet inject the medicament from the fluid chamber through the needle to the injection site.

22. The jet injector of claim 21, wherein the interference component is a ring having a proximal end and a distal end, the at least one abutment arm extending distally from the proximal end of the ring, the ring being dimensioned to fit within the housing.