Vagal nerve stimulator with mode switching

• US 9,486,631 B2
• Filed: 06/30/2014
• Issued: 11/08/2016
• Est. Priority Date: 05/25/2005
• Status: Active Grant

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Libbus, Imad, Kramer, Andrew P., Linder, William J., Stahmann, Jeffrey E.
• Primary Examiner(s): Bertram, Eric D.
• Application Number:
  US14/318,785
• Publication Number:
  US 20140316487A1
• Time in Patent Office: 862 Days
• Field of Search: 607/3
• US Class Current: 1/1
• CPC Class Codes: A61M 5/1723 using feedback of body parameters, e.g. blood-sugar, pressure measurement of body parameters A61B5/00
• CPC Class Codes: A61N 1/3605 Implantable neurostimulators for stimulating central or peripheral nerve system
• CPC Class Codes: A61N 1/36053 adapted for vagal stimulation A61N1/36114 takes precedence
• CPC Class Codes: A61N 1/36114 Cardiac control, e.g. by vagal stimulation stimulating the heart A61N1/362
• CPC Class Codes: A61N 1/36128 Control systems
• CPC Class Codes: A61N 1/36135 using physiological parameters
• CPC Class Codes: A61N 1/3688 configured for switching the pacing mode, e.g. from AAI to DDD

Abstract

Various aspects of the present subject matter relate to an implantable device. Various device embodiments comprise at least one port to connect to at least one lead with at least electrode, stimulation circuitry connected to the at least one port and adapted to provide at least one neural stimulation therapy to at least one neural stimulation target using the at least one electrode, sensing circuitry connected to the at least one port and adapted to provide a sensed signal, and a controller connected to the stimulation circuitry to provide the at least one neural stimulation therapy and to the sensing circuitry to receive the sensed signal. In response to a triggering event, the controller is adapted to switch between at least two modes. Other aspects and embodiments are provided herein.

Claims

1. A system for using at least one electrode to deliver vagal nerve stimulation therapy to vagus nerve in a patient, comprising:

an implantable device configured to be implanted in the patient, comprising;

stimulation circuitry configured to use the at least one electrode to deliver electrical stimulation to the vagus nerve;

memory including sets of programmed instructions stored therein to operate the device to deliver the vagal nerve stimulation in at least two different operating modes, wherein the implantable device is configured to change operating modes in response to an external signal, each of the at least two different operating modes is used to deliver vagal nerve stimulation therapy, and the sets of programmed instructions are concurrently in the memory and include different sets of programmed instructions to operate the device to deliver the vagal nerve stimulation therapy; and

a controller connected to the memory and the stimulation circuitry to control the stimulation circuitry, the controller configured to control delivery of the electrical stimulation for the neural stimulation therapy including change adjustable parameters to control delivery of the electrical stimulation for the neural stimulation therapy, the controller configured to execute the programmed instructions in the memory to operate the device to deliver the vagal nerve stimulation therapy in the at least two operating modes, the controller configured to receive the external signal transmitted from an external device external to the patient and respond to the received external signal by changing from executing one set of programmed instructions to operate the device to deliver the vagal nerve stimulation therapy in one of the operating modes to executing another, different set of programmed instructions to operate the device to deliver the vagal nerve stimulation therapy in another one of the operating modes.

2. The system of claim 1, wherein the controller is configured to receive a magnetic signal transmitted from the external device, and respond to the received magnetic signal by changing from executing one set of programmed instructions to operate the device to deliver the vagal nerve stimulation therapy in one of the operating modes to executing the other, different set of programmed instructions to operate the device to deliver the vagal nerve stimulation therapy in the other one of the operating modes.

3. The system of claim 1, wherein the at least one electrode includes an electrode configured to be placed around the vagus nerve.

4. The system of claim 1, wherein the at least one electrode includes an intravascular electrode configured to stimulate the vagus nerve.

5. The system of claim 1, wherein the controller is configured to change a dose of the neural stimulation therapy when executing the other, different set of programmed instructions to operate the device to deliver the vagal nerve stimulation therapy in the other one of the operating modes.

6. The system of claim 5, wherein the controller is configured to change stimulation sites to change the dose of the neural stimulation therapy.

7. The system of claim 1, wherein one of the different sets of programmed instructions includes programmed instructions to operate the device to deliver afferent vagal nerve stimulation, and the other set of programmed instructions includes programmed instructions to operate the device to deliver efferent vagal nerve stimulation.

8. The system of claim 1, wherein the system is configured to sense a physiological signal, wherein the operating modes include at least two modes selected from the group of modes consisting of:

a stimulation and sensing mode, a stimulation mode in which the neural stimulation therapy is provided without using the sensed signal, and a sensing mode in which the neural stimulation therapy is not provided to the neural stimulation target.

9. The system of claim 1, wherein one of the operating modes includes stimulation of the vagus nerve using the at least one electrode, and another operating mode includes stimulation of the vagus nerve using at least one other additional electrode.

10. The system of claim 1, wherein the operating modes include sensing at a first sensing site and sensing at a second sensing site.

11. The system of claim 10, wherein sensing includes sensing at least one of blood pressure, heart rate or nerve traffic.

12. The system of claim 1, wherein the operating modes include parasympathetic stimulation and sympathetic stimulation.

13. A system for using at least one electrode to deliver vagal nerve stimulation therapy to vagus nerve in a patient, comprising:

a patient-actuated external device configured to deliver a wireless signal; and

an implantable device configured to be implanted in the patient, comprising;

stimulation circuitry configured to use the at least one electrode to deliver electrical stimulation to the vagus nerve;

memory including sets of programmed instructions stored therein to operate the device to deliver the vagal nerve stimulation in at least two different operating modes, wherein the implantable device is configured to change operating modes in response to the wireless signal, each of the at least two different operating modes is used to deliver vagal nerve stimulation therapy, and the sets of programmed instructions are concurrently in the memory and include different sets of programmed instructions to operate the device to deliver the vagal nerve stimulation therapy; and

a controller connected to the memory and the stimulation circuitry to control the stimulation circuitry, the controller configured to control delivery of the electrical stimulation for the neural stimulation therapy including change adjustable parameters to control delivery of the electrical stimulation for the neural stimulation therapy, the controller configured to execute the programmed instructions in the memory to operate the device to deliver the vagal nerve stimulation therapy in the at least two operating modes, the controller configured to receive the wireless signal transmitted from the external device and respond to the received wireless signal by changing from executing one set of programmed instructions to operate the device to deliver the vagal nerve stimulation therapy in an operating mode to executing another, different set of programmed instructions to operate the device to deliver the vagal nerve stimulation therapy in another operating mode.

14. The system of claim 13, wherein the wireless signal includes a magnetic signal.

15. The system of claim 13, wherein the patient-actuated external device includes a magnet.

16. The system of claim 13, wherein the patient-actuated external device includes a programmer.

17. The system of claim 13, wherein the at least one electrode includes an electrode configured to be placed around the vagus nerve.

18. The system of claim 13, wherein the controller is configured to change a dose of the neural stimulation therapy when executing the other, different set of programmed instructions to operate the device to deliver the vagal nerve stimulation therapy in the other operating mode.

19. The system of claim 13, wherein one of the different sets of programmed instructions includes programmed instructions to operate the device to deliver afferent stimulation of the vagus nerve, and the other set of programmed instructions includes programmed instructions to operate the device to deliver efferent stimulation.

20. The system of claim 13, wherein one of the operating modes includes stimulation of the vagus nerve using the at least one electrode, and another operating mode includes stimulation of the vagus nerve using at least one other additional electrode.