Biosensor structures for improved point of care testing and methods of manufacture thereof
First Claim
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1. A biosensor comprising:
- an electrode;
a first printed layer formed on the electrode comprising a first matrix that includes creatinine amidohydrolase (CNH), creatine amidinohydrolase (CRH), and sarcosine oxidase (SOX);
a second printed layer formed over the first printed layer comprising a second matrix that includes CRH, SOX, and catalase; and
a third printed layer formed over the first printed layer such that the third printed layer is disposed between the first printed layer and the second printed layer, the third printed layer comprising a third matrix that includes CRH,wherein the second printed layer completely covers the third printed layer; and
wherein the third printed layer completely covers the first printed layer.
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Abstract
The present invention relates to analytical testing devices and methods for fabricating electrochemical creatinine biosensors, and in particular using point of care electrochemical biosensors for testing for creatinine in samples. For example, the present invention may be directed to a biosensor having an electrode, a first printed layer formed on the electrode and having a first matrix that includes creatinine amidohydrolase (CNH), creatine amidinohydrolase (CRH), and sarcosine oxidase (SOX), and second printed layer formed over the first printed layer and having a second matrix that includes CRH, SOX, and catalase.
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Citations
13 Claims
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1. A biosensor comprising:
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an electrode; a first printed layer formed on the electrode comprising a first matrix that includes creatinine amidohydrolase (CNH), creatine amidinohydrolase (CRH), and sarcosine oxidase (SOX); a second printed layer formed over the first printed layer comprising a second matrix that includes CRH, SOX, and catalase; and a third printed layer formed over the first printed layer such that the third printed layer is disposed between the first printed layer and the second printed layer, the third printed layer comprising a third matrix that includes CRH, wherein the second printed layer completely covers the third printed layer; and wherein the third printed layer completely covers the first printed layer. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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Specification