Methods and compositions comprising non-natural amino acids
First Claim
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1. A single stranded DNA polynucleotide-polypeptide conjugate comprising a polynucleotide covalently conjugated to a polypeptide, wherein the polynucleotide is at least 95% identical to SEQ ID NO:
- 26, wherein the polypeptide and polynucleotide are covalently conjugated via a non-naturally encoded amino acid in the amino acid sequence of the polypeptide, wherein the polypeptide is human growth hormone, and wherein the non-naturally encoded amino acid has the structure;
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Abstract
Disclosed herein are methods of detecting non-natural amino acids and polypeptides that include at least one non-natural amino acid. The non-natural amino acids, by themselves or as a part of a polypeptide, can include a wide range of functionalities, including but not limited to oxime, carbonyl, and/or hydroxylamine groups. Also disclosed herein are non-natural amino acid polypeptides that are further modified post-translationally, and methods for detecting such polypeptides.
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2 Claims
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1. A single stranded DNA polynucleotide-polypeptide conjugate comprising a polynucleotide covalently conjugated to a polypeptide, wherein the polynucleotide is at least 95% identical to SEQ ID NO:
- 26, wherein the polypeptide and polynucleotide are covalently conjugated via a non-naturally encoded amino acid in the amino acid sequence of the polypeptide, wherein the polypeptide is human growth hormone, and wherein the non-naturally encoded amino acid has the structure;
- View Dependent Claims (2)
- 26, wherein the polypeptide and polynucleotide are covalently conjugated via a non-naturally encoded amino acid in the amino acid sequence of the polypeptide, wherein the polypeptide is human growth hormone, and wherein the non-naturally encoded amino acid has the structure;
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Current AssigneeAmbrx, Inc. (Johnson & Johnson)
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Original AssigneeAmbrx, Inc. (Johnson & Johnson)
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InventorsBuechler, Ying, Miao, Zhenwei, Tian, Feng, Hays Putnam, Anna-Maria A.
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Primary Examiner(s)Hibbert, Catherine S
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Assistant Examiner(s)Mahatan, Channing S
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Application NumberUS12/902,010Publication NumberTime in Patent Office2,220 DaysField of SearchNoneUS Class Current1/1CPC Class CodesG01N 33/6812 Assays for specific amino a...
