Magnetic resonance imaging apparatus and magnetic resonance imaging method

• US 9,488,711 B2
• Filed: 11/12/2014
• Issued: 11/08/2016
• Est. Priority Date: 11/13/2013
• Status: Active Grant

• Current Assignee: Toshiba Medical Systems Corporation (Canon Inc.)
• Original Assignee: Toshiba Medical Systems Corporation (Canon Inc.)
• Inventors: Kimura, Tokunori
• Primary Examiner(s): NAKHJAVAN, SHERVIN K
• Application Number:
  US14/539,584
• Publication Number:
  US 20150131884A1
• Time in Patent Office: 727 Days
• Field of Search: None
• US Class Current: 1/1
• CPC Class Codes: A61B 5/02007 Evaluating blood vessel condition, e.g. elasticity, compliance
• CPC Class Codes: A61B 5/0263 using NMR
• CPC Class Codes: A61B 5/055 involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
• CPC Class Codes: A61B 5/489 Blood vessels
• CPC Class Codes: G01R 33/5602 by filtering or weighting based on different relaxation times within the sample, e.g. T1 weighting using an inversion pulse
• CPC Class Codes: G01R 33/5607 by reducing the NMR signal of a particular spin species, e.g. of a chemical species for fat suppression, or of a moving spin species for black-blood imaging
• CPC Class Codes: G01R 33/5635 Angiography, e.g. contrast-enhanced angiography [CE-MRA] or time-of-flight angiography [TOF-MRA]

Abstract

According to one embodiment, an MRI apparatus includes a data acquiring part and a data processing part. The data acquiring part acquires first and second MR signals by applying at least one IR pulse under an application condition according to a relaxation time of a fluid. The first MR signals include MR signals, having negative values, from the fluid. The second MR signals include MR signals, having positive values, from the fluid. The data processing part generates first and second image data. The first image data depict the fluid as a lower signal region than that of a tissue. The second image data depict the fluid as a higher signal region than that of the tissue. The data processing part generates the first image data with a phase correction based on the second MR signals.

Claims

1. A magnetic resonance imaging (MRI) apparatus comprising:

at least one radio frequency (RF) coil disposed within static and gradient magnetic field generators, an RF transmitter and an RF receiver coupled to said at least one RE coil, and at least one control computer connected to control said gradient magnetic field generators, said RF transmitter, said RF transmitter and said RF receiver to execute MRI data acquisition sequences and to process acquired MRI signals;

said at least one control computer being configured to

acquire first and second magnetic resonance signals from a flowing fluid within same imaging area of an object using at least one inversion recovery pulse related to a MR relaxation time of a flowing fluid within the object, the first magnetic resonance signals, from the fluid including negative values, the second magnetic resonance signals from the fluid including positive values, and

generate first and second image data based, respectively, on the first and second magnetic resonance signals, the first image data depicting the fluid as a lower signal region than a signal region of surrounding tissue, the second image data depicting the fluid as a higher signal region than a signal region of the surrounding tissue;

the first image data being generated with a phase correction based on the second magnetic resonance signals.

2. The magnetic resonance imaging apparatus of claim 1, wherein:

phase correction of real space signals is performed using phase data and the first image data is generated by imaging real parts of the real space signals after the phase correction, the real space signals being generated based on the first magnetic resonance signals, the phase data being obtained based on the second magnetic resonance signals.

3. The magnetic resonance imaging apparatus of claim 1, wherein:

the at least one inversion recovery pulse is applied repeatedly and a part of the first magnetic resonance signals and a part of the second magnetic resonance signals are alternately acquired between repeated applications of the at least one inversion recovery pulse.

4. The magnetic resonance imaging apparatus of claim 1, wherein:

a first inversion recovery pulse is applied in a first application region and a second inversion recovery pulse is applied in a second application region, the first application region being larger than the imaging area, the second application region being larger than the imaging area and smaller than the first application region, the first application region being set to make magnetic resonance signals from the fluid, having flowed from an outside into the imaging area, show negative values at acquisition timing of the first magnetic resonance signals, the second application region being set to make magnetic resonance signals from the fluid, having flowed from an outside into the imaging area, show positive values at acquisition timing of the second magnetic resonance signals; and

longitudinal relaxation weighted image data is generated as the first image data and the second image data.

5. The magnetic resonance imaging apparatus of claim 1, wherein:

a first inversion recovery pulse is applied and a second inversion recovery pulse is applied, the first inversion recovery pulse being applied in each of a first application region and a second application region after a predetermined time interval, the first application region being larger than the imaging area, the first application region being set to make magnetic resonance signals from the fluid, having flowed from an outside into the imaging area, show negative values at acquisition timing of the first magnetic resonance signals, the second application region being larger than the imaging area and smaller than the first application region, the second inversion recovery pulse being applied twice in a third application region with the predetermined time interval or another predetermined time interval, the third application region being larger than the imaging area and smaller than the first application region, the third application region being same as or different from the second application region, the third application region being set to make magnetic resonance signals from the fluid, having flowed from an outside into the imaging area, show positive values at acquisition timing of the second magnetic resonance signals; and

transverse relaxation weighted image data or proton density weighted image data is generated as the first image data and the second image data.

6. The magnetic resonance imaging apparatus of claim 1, wherein:

an inversion recovery pulse is applied in an application region outside the imaging area and the second magnetic resonance signals are acquired with no inversion recovery pulse being applied, the application region being set to make magnetic resonance signals from the fluid, having flowed from an outside into the imaging area, show negative values at acquisition timing of the first magnetic resonance signals; and

transverse relaxation weighted image data or proton density weighted image data is generated as the first image data and the second image data.

7. The magnetic resonance imaging apparatus of claim 1, wherein:

the first magnetic resonance signals are acquired by applying the at least one inversion recovery pulse and the second magnetic resonance signals are acquired without applying an inversion recovery pulse, the second magnetic resonance signals including magnetic resonance signals from the tissue and magnetic resonance signals from the fluid having flowed into the imaging area, intensities of the magnetic resonance signals from the tissue being suppressed by repeatedly applying a radio frequency excitation pulse to the imaging area with a repetition time shorter than a longitudinal relaxation time of the tissue, the magnetic resonance signals from the fluid having positive values.

8. The magnetic resonance imaging apparatus of claim 1, wherein:

at least multiple sets of the first magnetic resonance signals are acquired, the sets respectively corresponding to at least one of (a) different inversion times and (b) different echo times; and

image data is generated showing at least one of a distribution of a longitudinal relaxation time, a distribution of a transverse relaxation time, a distribution of a permeability of the fluid to the tissue and blood dynamic state image data, based on at least the multiple sets of the first magnetic resonance signals.

9. The magnetic resonance imaging apparatus of claim 1, wherein:

the first magnetic resonance signals and the second magnetic resonance signals are acquired using inversion times which are effectively the same; and

the second image data is generated as image data, in which a depiction of the tissue is suppressed and the fluid is depicted, by subtraction processing between image data generated based on the first magnetic resonance signals and image data generated based on the second magnetic resonance signals.

10. The magnetic resonance imaging apparatus of claim 1, wherein:

the first magnetic resonance signals and the second magnetic resonance signals are acquired after applying a common inversion recovery pulse.

11. The magnetic resonance imaging (MRI) apparatus comprising:

at least one radio frequency (RF) coil disposed within static and gradient magnetic field generators, an RE transmitter and an RF receiver coupled to said at least one RF coil, and at least one control computer connected to control said gradient magnetic field generators, said RF transmitter, said RF transmitter and said RF receiver to execute MRI data acquisition sequences and to process acquired MRI signals;

said at least one control computer being configured to

acquire magnetic resonance signals from an imaging area of an object by applying at least one inversion recovery pulse related to relaxation times of a first component to be a suppression target and a second component to be a weighted target, the magnetic resonance signals including signals, having negative values, from the first component and signals, having positive values, from the second component, the magnetic resonance signals corresponding to an asymmetric sampling region in at least one direction in k-space; and

generate real space image data including a phase correction based on the acquired magnetic resonance signals, the image data depicting the first component as a lower signal region than a signal region of the second component.

12. The magnetic resonance imaging apparatus of claim 11, wherein:

the magnetic resonance signals are acquired by a spin echo series of an MRI pulse sequence.

13. The magnetic resonance imaging apparatus of claim 12, wherein:

the magnetic resonance signals are acquired by applying refocus pulses having at least two different flip angles.

14. The magnetic resonance imaging apparatus of claim 11, wherein:

the phase correction is performed using phase data obtained based on the magnetic resonance signals.

15. The magnetic resonance imaging apparatus of claim 14, wherein:

the phase data is obtained based on magnetic resonance signals in a narrow region in a lower frequency side in at least one direction than a symmetric low frequency region out of the sampling region.

16. The magnetic resonance imaging apparatus of claim 14, wherein:

the phase data is obtained based on magnetic resonance signals in a symmetric low frequency region out of the sampling region.

17. The magnetic resonance imaging apparatus of claim 14, wherein:

the phase data is obtained by inverting a phase of a real space signal determined to have shifted by 180 degrees from a phase of a real space signal corresponding to the second component, the real space signal corresponding to the second component being obtained based on the magnetic resonance signals, inversion of the phase being performed for each voxel.

18. The magnetic resonance imaging apparatus of claim 14, wherein:

the phase data is obtained by an interpolation based on a phase distribution of real space signals corresponding to the second component, the real space signals corresponding to the second component being obtained based on the magnetic resonance signals.

19. The magnetic resonance imaging apparatus of claim 11, wherein:

the phase correction is performed using phase data obtained based on reference image data, the reference image data being generated using original data which are magnetic resonance signals different from the magnetic resonance signals acquired from the imaging area.

20. The magnetic resonance imaging apparatus of claim 11, wherein:

magnetic resonance signals having the negative values are acquired from blood as the first component and magnetic resonance signals having the positive values are acquired from a tissue as the second component.

21. A magnetic resonance imaging (MRI) method comprising:

controlling gradient magnetic field generators, a radio frequency (RF) transmitter and an RF receiver coupled to at least one RF coil disposed in an imaging volume of an MRI system to effect;

acquiring first and second magnetic resonance signals from a same imaging area of an object by applying at least one inversion recovery pulse according to a relaxation time of a fluid flowing within the object, the first magnetic resonance signals from the fluid, having negative values, the second magnetic resonance signals from the fluid, having positive values; and

generating first and second image data, respectively based on the first and second magnetic resonance signals, the first image data depicting the fluid as a lower signal region than a signal region of a tissue, the second image data depicting the fluid as a higher signal region than a signal region of the tissue;

wherein the first image data are generated with a phase correction based on the second magnetic resonance signals.