Intraoperative imaging system and apparatus

• US 9,492,080 B2
• Filed: 05/01/2015
• Issued: 11/15/2016
• Est. Priority Date: 07/30/2010
• Status: Active Grant

• Current Assignee: Adventus Technologies, Inc.
• Original Assignee: Adventus Technologies, Inc.
• Inventors: Uhlhorn, Stephen Roger, Ruggeri, Marco, Manns, Fabrice, Parel, Jean-Marie Arthur
• Primary Examiner(s): SAHLE, MAHIDERE S
• Application Number:
  US14/702,213
• Publication Number:
  US 20150230702A1
• Time in Patent Office: 564 Days
• Field of Search: 351/205, 351/206, 351/221, 600/407, 600/425
• US Class Current: 1/1
• CPC Class Codes: A61B 3/0025 characterised by electronic signal processing, e.g. eye models
• CPC Class Codes: A61B 3/102 for optical coherence tomography [OCT]
• CPC Class Codes: A61B 3/1173 for examining the eye lens
• CPC Class Codes: A61B 3/1225 using coherent radiation
• CPC Class Codes: A61B 3/13 Ophthalmic microscopes
• CPC Class Codes: A61B 3/14 Arrangements specially adapted for eye photography apparatus or arrangements for taking photographs per se G03B
• CPC Class Codes: A61B 5/7207 of noise induced by motion artifacts

Abstract

Systems, methods and apparatuses for an intraocular imaging system are disclosed comprising an optical coherence tomography (OCT) system. The OCT system has an imaging range that may enable substantial portions of an eye or even a whole eye to be imaged. The OCT system may be coupled to an operation microscope, such that, for example, a surgeon can visualize ocular structures like the human crystalline lens and other ocular structures such as the cornea and/or vitreous while surgical instruments are in the field of view.

Claims

1. An intraocular imaging method comprising:

receiving image data representing image information of an ocular system from a plurality of images having a corresponding plurality of depth ranges, wherein at least two of the plurality of depth ranges overlap;

identifying a portion of at least one image that overlaps with a portion of at least one other image;

cropping said portion of at least one image; and

generating a composite image from the remainder of the plurality of images;

wherein at least one of the plurality of images is a subsurface image; and

wherein generating a composite image comprises forming from the image data a single image for the overlapping portion of the depth ranges.

2. The method of claim 1 wherein the plurality of depth ranges is three or more depth ranges.

3. The method of claim 2, wherein said at least two of the depth ranges that overlap are over an anterior segment of the ocular system and at least one of said depth ranges is over a retina of the ocular system.

4. The method of claim 3, wherein the plurality of depth ranges is at least four depth ranges, and at least one depth range is over a vitreous humor of the ocular system.

5. The method of claim 3, wherein said forming from the image data a single image for the overlapping portion of the depth range comprises removing artifacts from the image data.

6. The method of claim 3, wherein a first of said depth ranges that overlap has a zero delay location anterior to the cornea and a second one of said depth ranges that overlap has a zero delay location posterior to the crystalline lens.

7. The method of claim 6, wherein the first and second depth ranges overlap with each other.

8. The method of claim 3, wherein the depth range over the retina has a zero delay location near to the vitreo-retinal boundary.

9. An intraocular imaging system comprising:

imaging optics configured to obtain a plurality of images at a corresponding plurality of imaging ranges, at least two of the plurality of imaging ranges overlapping;

image processor circuitry configured in at least one of hardware and software to receive and process images to form, from the received plurality of images, a composite image comprising a single image for the overlapping portion of the imaging ranges;

wherein said single image is obtained by identifying a portion of at least one image corresponding to an overlapping depth range and cropping said portion; and

wherein at least one of the plurality of images is a subsurface image.

10. The intraocular imaging system of claim 9, wherein the plurality of different imaging ranges comprises at least three optical paths.

11. The intraocular imaging system of claim 10, wherein said overlapping image ranges comprise a first and a second image range and the plurality of images ranges comprises a third image range posterior to the first and second image ranges and spaced apart from the first and second image ranges a distance enabling the first and second image ranges to include a crystalline lens of a human eye and the third image range to include a retina of the eye.

12. The intraocular imaging system of claim 10, wherein said overlapping image ranges comprise a first and a second image range and the plurality of images ranges comprises a third image range posterior to the first and second image ranges and spaced apart from the first and second image ranges a distance enabling the first and second image ranges to include a cornea and crystalline lens of a human eye and the third image range to include a retina of the eye.

13. An intraocular imaging system comprising:

imaging optics forming an optical coherence tomography system configured to obtain a plurality of images at a corresponding plurality of different imaging ranges about respective zero delay locations, at least two of the plurality of imaging ranges overlapping;

an image output configured to receive image information at the plurality of different image ranges and output the image information in a machine readable form;

wherein said image output comprises identifying a portion of at least one image corresponding to overlapping depth ranges;

cropping said portion; and

wherein at least one of the plurality of images is a subsurface image.

14. The intraocular imaging system of claim 13, wherein the machine readable form comprises light signals and the image output is a connection suitable for transmitting said light signals of an optical fiber.

15. The intraocular imaging system of claim 13, configured so that the imaging ranges of said overlapping imaging ranges are locatable so that a zero delay location of a first of the overlapping imaging ranges is anterior to a cornea of a human eye and a zero delay location of a second of the overlapping imaging ranges is posterior to the crystalline lens of the eye.

16. The intraocular imaging system of claim 15, configured to image at a third imaging range, the third imaging range located so as to include the retina of the eye.

17. The intraocular imaging system of claim 16, configured to switch between the imaging ranges in about 300 microseconds.

18. The intraocular imaging system of claim 17, wherein the imaging optics comprises a light source with a center wavelength between 835 nm and 1300 nm and a full-width, half-maximum bandwidth between 50 nm and 200 run.

19. The intraocular imaging system of claim 13, wherein each imaging range is about 10 to 12 mm in air.