Medical sensor system

• US 9,492,109 B2
• Filed: 10/05/2011
• Issued: 11/15/2016
• Est. Priority Date: 10/07/2010
• Status: Expired due to Fees

• Current Assignee: Biotronik SE & Company KG
• Original Assignee: Biotronik SE & Company KG
• Inventors: Bunge, Andreas, Biela, Sarah, Bode, Sven, Naehring, Joerg, Trieu, Hoc Khiem, Urban, Gerald
• Primary Examiner(s): WESTON, TIFFANY C
• Application Number:
  US13/253,121
• Publication Number:
  US 20120088990A1
• Time in Patent Office: 1,868 Days
• US Class Current: 1/1
• CPC Class Codes: A61B 2562/0285 Nanoscale sensors
• CPC Class Codes: A61B 5/14503 invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors A61B5/1459, A61B5/1464, A61B5/1473, A61B5/1482, A61B5/14865 take precedence
• CPC Class Codes: A61B 5/14539 for measuring pH
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/14735 comprising an immobilised reagent
• CPC Class Codes: A61B 5/4839 combined with drug delivery

Abstract

A medical sensor system (10, 10′) for detecting at least one characteristic (12) of an human and/or animal body has a sensor (14), a first characteristic carrier (16), and a characteristic carrier receptor (18). The first characteristic carrier (16) differs, in terms of at least one characteristic parameter, from a second characteristic carrier (20) which is present at least at the time of detection. The sensor (14) is preferably located in vivo at the time of detection of the at least one characteristic.

Claims

1. A medical sensor system (10, 10′

) for detecting a characteristic (12) of a human and/or animal body, the sensor system (10, 10′

) including;

a. a characteristic carrier receptor (18) configured to bind to a second characteristic carrier (20) of interest for sensing;

b. a first characteristic carrier (16);

(1) different from the second characteristic carrier (20), and

(2) configured to bind to the characteristic carrier receptor (18) in competition with the second characteristic carrier (20);

c. a sensor (14) configured to generate a signal dependent on the binding of at least one of the first characteristic carrier (16) and the second characteristic carrier (20) to the characteristic carrier receptor (18);

d. a reservoir (38) wherein the sensor (14) is situated, and

e. an organic membrane (36, 36a) closing the reservoir (38), wherein the organic membrane (36, 36a);

(1) always retains the first characteristic carrier (16) within the reservoir (38), and

(2) is controllable to selectively allow and deny entry of the second characteristic carrier (20) into the reservoir (38).

2. The medical sensor system of claim 1 wherein the sensor (14) is configured to generate an electrical signal dependent on the binding of at least one of the first characteristic carrier (16) and the second characteristic carrier (20) to the characteristic carrier receptor (18).

3. The medical sensor system of claim 1 wherein the sensor (14) is configured to generate a voltage signal dependent on the binding of at least one of the first characteristic carrier (16) and the second characteristic carrier (20) to the characteristic carrier receptor (18).

4. The medical sensor system of claim 1 wherein the sensor (14) includes a semiconductor component (22) configured to generate the binding-dependent signal.

5. The medical sensor system of claim 4 wherein the semiconductor component (22) includes a gate (24) whereupon the characteristic carrier receptor (18) is located.

6. The medical sensor system of claim 1 wherein the sensor (14) includes a region (24) coated with the characteristic carrier receptor (18).

7. The medical sensor system of claim 6 further including a passivating layer (44) on the region (24) of the sensor (14), the passivating layer being configured to saturate non-specific binding sites (46).

8. The medical sensor system of claim 1 wherein the characteristic carrier receptor (18) is defined by a molecule having an antigen recognition site (26).

9. The medical sensor system of claim 1 wherein:

a. the second characteristic carrier (20) is defined by an analyte (30) that has an antigen (28), and

b. the first characteristic carrier (16) is defined by an antagonist (32) of the analyte (30).

10. The medical sensor system of claim 1 wherein the first characteristic carrier (16) has a higher charge (34) than the second characteristic carrier (20).

11. The medical sensor system of claim 1 wherein the organic membrane (36a) is electrically controllable.

12. The medical sensor system of claim 1 further including a reference sensor (44) configured to generate a background signal representative of the absence of the second characteristic carrier (20) from the reservoir (38).

13. The medical sensor system of claim 1 further including a surface coating (48) applied to the membrane (36, 36a), the surface coating (48) being configured to prevent interactions with interfering substances (52).

14. The medical sensor system of claim 1 wherein:

a. the reservoir (38) is at least partially filled with fluid, and

b. the first characteristic carrier (16) is dispersed throughout the fluid.

15. The medical sensor system of claim 1 further including a medical implant (54) whereupon or wherein the medical sensor system (10, 10′

) is situated.

16. The medical sensor system of claim 1 wherein the characteristic carrier receptor (18) includes at least a portion of a monoclonal antibody configured to bind to the first characteristic carrier (16) and the second characteristic carrier (20).

17. A method for operating the medical sensor system of claim 1 including the step of determining the change in the binding-dependent signal when the sensor (14) is located in vivo.

18. A medical sensor system for detecting a characteristic of a human and/or animal body, the sensor system including:

a. a reservoir;

b. a first characteristic carrier within the reservoir;

c. a sensor within the reservoir, the sensor being configured to generate a signal dependent on the relative amounts of;

(1) the first characteristic carrier adjacent the sensor, and

(2) a second characteristic carrier adjacent the sensor,

d. a membrane closing the reservoir, the membrane having a pore therein, the pore having a pore size which is controllable to selectively;

(1) allow passage of the second characteristic carrier into the reservoir, and

(2) prevent passage of the second characteristic carrier into the reservoir.

19. The medical sensor system of claim 18 wherein the pore size is electrically controllable.

20. A medical sensor system for detecting a characteristic of a human and/or animal body, the sensor system including:

a. a reservoir;

b. a characteristic carrier receptor within the reservoir, the characteristic carrier receptor being configured to competitively bind to;

(1) a first characteristic carrier, and

(2) a second characteristic carrier of interest for sensing,

c. a membrane closing the reservoir, the membrane being configured to;

(1) restrain the first characteristic carrier within the reservoir, and

(2) selectively allow entry of the second characteristic carrier into the reservoir in response to a control signal;

d. a sensor configured to generate a signal dependent on the amount of at least one of the first characteristic carrier and the second characteristic carrier bound to the characteristic carrier receptor.

21. The medical sensor system of claim 20, wherein the membrane having a pore therein, the pore size being electrically controllable.