Implant for the treatment of glaucoma

• US 9,492,319 B2
• Filed: 08/13/2013
• Issued: 11/15/2016
• Est. Priority Date: 02/23/2011
• Status: Active Grant

• Current Assignee: Grieshaber Ophthalmic Research Foundation
• Original Assignee: Grieshaber Ophthalmic Research Foundation
• Inventors: Grieshaber, Hans R., Grieshaber, Matthias C., Stegmann, Robert C.
• Primary Examiner(s): Wiest, Philip R
• Assistant Examiner(s): Klein, Benjamin
• Application Number:
  US13/965,650
• Publication Number:
  US 20130331760A1
• Time in Patent Office: 1,190 Days
• US Class Current: 1/1
• CPC Class Codes: A61F 2210/0014 using shape memory or superelastic materials, e.g. nitinol
• CPC Class Codes: A61F 9/00781 Apparatus for modifying intraocular pressure, e.g. for glaucoma treatment drainage implants in general A61M27/002

Abstract

The invention refers to a tube configured as an implant for insertion at least at one location into the exposed Schlemm'"'"'s canal of an eye and which, for example, has been mechanically dilated. The elongated tube insertable into the Schlemm'"'"'s canal includes a plurality openings that are arranged at the tube in axial direction distanced from each other by ring parts and that are in communication with the trabecular tissue the interior space of the tube and the aqueous humor veins of the episcleral vein system and further includes openings oriented in axial direction at a circular arc shaped segment corresponding to the cross section profile of the tube. To realize the natural trabecular aqueous humor drainage, the tube are inserted into the Schlemm'"'"'s canal that either the openings in the segment are in communication with the aqueous humor veins or that segment with the openings are associated with the trabecular tissue.

Claims

1. A one-piece implant for the treatment of glaucoma in an eye by drainage of the transtrabecular aqueous humor of Schlemm'"'"'s canal comprising:

a flexible, bendable tube which extends in an axial direction, the tube having a circular cross section;

the tube further comprising;

(1) an outer wall having a plurality of openings spaced apart in the axial direction and in a circumferential direction;

the plurality of openings comprising a plurality of first openings and a plurality of second openings;

(2) the plurality of first openings distributed at the outer wall of the tube;

(3) an axially extending segment comprising the plurality of second openings, the second openings arranged distanced from each other in the axial direction, and configured as rectangular elongated holes separated by webs;

(4) a plurality of circular arc shaped ring parts distanced from each other in the axial direction such that the first openings are formed therebetween, and wherein the first openings extend in the circumferential direction from one side of the segment to an opposite side of the segment, each of said first openings having an angle of 290°

to 310°

around the circumference of the tube.

2. The implant of claim 1, wherein each ring part is at a side opposite the segment, and divided by a slot into two ring portions, wherein each slot is arranged in the axial direction of the tube such that the ring portions can be spread apart relative to one another and can return to their original shape.

3. The implant of claim 2, wherein each slot is Z-shaped.

4. The implant of claim 1, wherein the tube is made from biologically compatible material.

5. The implant of claim 4, wherein the tube is made from polymeric material having thermal- or mechanic shape memory and is provided with a heparin-coating.

6. The implant of claim 4, wherein the tube is made from gold.

7. The implant of claim 4, wherein the tube is made from nitinol.

8. The implant of claim 1, wherein the tube is bendable into a circular arc shape and flexible relative to the cross section of the tube.

9. The implant according to claim 1, wherein the first openings are arranged in a geometric pattern in the wall of tube and the segment provided with the second openings and the circular arc shaped ring parts are produced by means of microlaser treatment.

10. The implant according to claim 9, wherein edges that resulted from the laser treatment at the tube are rounded with a radius of 0.025 mm to 0.2 mm.

11. The implant according to claim 10, wherein the edges of the circular arc shaped ring part are rounded with a radius of 0.025 mm to 0.2 mm.

12. The implant according to claim 1, wherein the first openings are arranged in a geometric pattern in the wall of tube and the segment provided with the second openings and the circular arc shaped ring parts are produced by means of an excimer laser.