Compositions of hyaluronan with high elasticity and uses thereof
First Claim
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1. A high elasticity composition suitable for intra-articular injection comprising hyaluronan, wherein:
- the hyaluronan is present in said composition at a concentration of greater than 30 mg/mL;
the hyaluronan has an average molecular weight of between 1.3 and 2 million;
the hyaluronan is not cross-linked and/or is substantially free of chemical modifications;
wherein the composition is substantially free of a pharmaceutically active substance selected from the group consisting of a protein, a glycosaminoglycan that is different from hyaluronan, hydroxypropyl methyl cellulose and a local anesthetic;
wherein the composition is sterile; and
wherein the composition has an elasticity (G′
) of at least 900 Pascal when measured at a frequency of 5.0 Hz.
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Abstract
The present invention provides compositions comprising hyaluronan with high elasticity, as well as methods for improving joint function, reducing pain associated with joint function and treating osteoarthritis by introducing into a joint a therapeutically effective amount of a composition comprising hyaluronan with high elasticity.
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Citations
45 Claims
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1. A high elasticity composition suitable for intra-articular injection comprising hyaluronan, wherein:
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the hyaluronan is present in said composition at a concentration of greater than 30 mg/mL; the hyaluronan has an average molecular weight of between 1.3 and 2 million; the hyaluronan is not cross-linked and/or is substantially free of chemical modifications; wherein the composition is substantially free of a pharmaceutically active substance selected from the group consisting of a protein, a glycosaminoglycan that is different from hyaluronan, hydroxypropyl methyl cellulose and a local anesthetic; wherein the composition is sterile; and wherein the composition has an elasticity (G′
) of at least 900 Pascal when measured at a frequency of 5.0 Hz. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 34, 36, 39, 41, 43, 45)
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9. A high elasticity composition suitable for intra-articular injection comprising hyaluronan, wherein:
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the hyaluronan is present in said composition at a concentration of 40 mg/mL or greater; the hyaluronan has an average molecular weight of between 1 and 2 million; the hyaluronan is not cross-linked and/or is substantially free of chemical modifications; wherein the composition is substantially free of a pharmaceutically active substance selected from the group consisting of a protein, a glycosaminoglycan that is different from hyaluronan, hydroxypropyl methyl cellulose and a local anesthetic; wherein the composition is sterile; and wherein the composition has an elasticity (G′
) of at least 900 Pascal when measured at a frequency of 5.0 Hz. - View Dependent Claims (10, 11, 12, 13, 14, 15, 33, 35, 37, 38, 40, 42, 44)
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Specification