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Compositions of hyaluronan with high elasticity and uses thereof

  • US 9,492,474 B2
  • Filed: 07/09/2014
  • Issued: 11/15/2016
  • Est. Priority Date: 07/10/2013
  • Status: Active Grant
First Claim
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1. A high elasticity composition suitable for intra-articular injection comprising hyaluronan, wherein:

  • the hyaluronan is present in said composition at a concentration of greater than 30 mg/mL;

    the hyaluronan has an average molecular weight of between 1.3 and 2 million;

    the hyaluronan is not cross-linked and/or is substantially free of chemical modifications;

    wherein the composition is substantially free of a pharmaceutically active substance selected from the group consisting of a protein, a glycosaminoglycan that is different from hyaluronan, hydroxypropyl methyl cellulose and a local anesthetic;

    wherein the composition is sterile; and

    wherein the composition has an elasticity (G′

    ) of at least 900 Pascal when measured at a frequency of 5.0 Hz.

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