Medicament injection device and priming operation

• US 9,492,618 B2
• Filed: 05/24/2012
• Issued: 11/15/2016
• Est. Priority Date: 05/25/2011
• Status: Active Grant

• Current Assignee: Sanofi-Aventis Deutschland GmbH (Sanofi )
• Original Assignee: Sanofi-Aventis Deutschland GmbH (Sanofi )
• Inventors: Day, Shane Alistair
• Primary Examiner(s): LANDRY II, GERALD ERNEST
• Application Number:
  US14/119,420
• Publication Number:
  US 20140114258A1
• Time in Patent Office: 1,636 Days
• Field of Search: 604 65- 67, 604/187, 604/191, 604/506
• US Class Current: 1/1
• CPC Class Codes: A61M 2005/1402 Priming
• CPC Class Codes: A61M 2005/2414 from the side
• CPC Class Codes: A61M 2005/2496 via pivot
• CPC Class Codes: A61M 5/1407 Infusion of two or more substances
• CPC Class Codes: A61M 5/2066 comprising means for injection of two or more media, e.g. by mixing
• CPC Class Codes: A61M 5/2448 comprising means for injection of two or more media, e.g. by mixing
• CPC Class Codes: A61M 5/3146 Priming, e.g. purging, reducing backlash or clearance
• CPC Class Codes: A61M 5/31546 Electrically operated dose setting, e.g. input via touch screen or plus/minus buttons
• CPC Class Codes: A61M 5/31595 Pre-defined multi-dose administration by repeated overcoming of means blocking the free advancing movement of piston rod, e.g. by tearing or de-blocking

Abstract

A medicament delivery device for the administration of one or more drug agents is described. The device has a priming mode and a drug delivery mode for administering delivery of the drug agents. The device includes a controller operative for controlling the device to perform a priming operation, and a user interface for activation of the priming operation. The controller is operative to perform the priming operation by way of a plurality of intermittent doses of medicament, the number of intermittent doses being dependent on the activation of the user interface.

Claims

1. A hand-held insulin injection pen for the administration of one or more drug agents, the pen having at least a priming mode and a drug delivery mode for administering delivery of the one or more drug agents, wherein the pen comprises

a controller operative for controlling the pen to perform a priming operation, and

a user interface for activation of the priming operation,

wherein the controller is operative to perform the priming operation by way of a plurality of intermittent doses of medicament, the number of intermittent doses being dependent on the activation of the priming operation by the user interface, wherein the plurality of intermittent doses comprises a sequence of priming doses predetermined by the controller prior to activation of the priming operation by the user interface.

2. A hand-held insulin injection pen according to claim 1, wherein an interval between the plurality of intermittent doses decreases with time.

3. A hand-held insulin injection pen according to claim 1, wherein an interval between the plurality of intermittent doses increases with time.

4. A hand-held insulin injection pen according to claim 1, wherein a quantity of medicament of the plurality of intermittent doses decreases with time.

5. A hand-held insulin injection pen according to claim 1, wherein a quantity of medicament of the plurality of intermittent doses increases with time.

6. A hand-held insulin injection pen according to claim 1, wherein the user interface comprises a priming and/or dosing button.

7. A hand-held insulin injection pen according to claim 1, wherein the controller has at least one memory for storing priming history and for storing dose administration history.

8. A hand-held insulin injection pen according to claim 1, wherein the controller is operative to limit the number of intermittent doses for a given priming operation to a preset value.

9. A hand-held insulin injection pen according to claim 1, wherein the controller is operative to select between different priming strategies stored in a memory.

10. A hand-held insulin injection pen according to claim 9, comprising first and second medicament cartridge retainers each for holding a medicament cartridge.

11. A hand-held insulin injection pen according to claim 10, wherein a first strategy is to perform the priming operation from the medicament cartridge of one of said first and second medicament cartridge retainers, and a second strategy is to perform the priming operation from the medicament cartridges of both of the first and second medicament cartridge retainers.

12. A hand-held insulin injection pen according to claim 11, wherein the second strategy comprises priming from the medicament cartridge of one of the first and second medicament cartridge retainers at a different rate from the other.

15. A hand-held insulin injection pen according to claim 1, wherein the activation of the priming operation comprises continuous activation of a priming button of the user interface.

13. A method of controlling a hand-held insulin injection pen for the ejection of one or more drug agents, the pen having at least a priming mode and a drug delivery mode for administering delivery of the one or more drug agents, the method comprising:

controlling the pen to perform a priming operation; and

administering a plurality of intermittent doses of medicament in dependence on activation of the priming operation by a user interface, wherein the plurality of intermittent doses comprises a sequence of priming doses predetermined by the controller prior to activation of the priming operation by the user interface.

14. A method according to claim 13, comprising varying the time or volume sequence of the intermittent doses.

16. A hand-held medicament injection pen for the administration of one or more drugs, comprising:

a user interface having a priming button for controlling a priming operation; and

a controller operative for;

determining a sequence of intermittent priming doses;

detecting activation of a priming button via the user interface;

responsive to detecting activation of the priming button, starting the priming operation to dispense the intermittent priming doses according to the determined sequence;

detecting release of the priming button via the user interface prior to completion of the sequence; and

responsive to detecting release of the priming button, stopping the priming operation to stop dispensing the intermittent priming doses prior to completion of the sequence.

17. A hand-held medicament injection pen according to claim 16, wherein the controller is operative to limit the sequence to a preset number of intermittent doses.

18. A hand-held medicament injection pen according to claim 16, wherein the controller is operative to determine the sequence such that a first interval between first successive doses in the sequence is greater than a second interval between second successive doses in the sequence.

19. A hand-held medicament injection pen according to claim 16, wherein the controller is operative to determine the sequence such that a quantity of medicament dispensed for each intermittent priming dose decreases over the sequence.

20. A hand-held medicament injection pen according to claim 16, wherein the controller is operative to determine the sequence based on a selection, via the user interface, of a dose profile from among a plurality of dose profiles.