Mode switching by a ventricular leadless pacing device

• US 9,492,668 B2
• Filed: 11/11/2014
• Issued: 11/15/2016
• Est. Priority Date: 11/11/2014
• Status: Active Grant

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Sheldon, Todd J, Demmer, Wade M
• Primary Examiner(s): FAIRCHILD, MALLIKA DIPAYAN
• Application Number:
  US14/538,518
• Publication Number:
  US 20160129262A1
• Time in Patent Office: 735 Days
• US Class Current: 1/1
• CPC Class Codes: A61N 1/36592 controlled by the heart rate variability
• CPC Class Codes: A61N 1/3688 configured for switching the pacing mode, e.g. from AAI to DDD
• CPC Class Codes: A61N 1/3756 Casings with electrodes thereon, e.g. leadless stimulators

Abstract

In some examples, a leadless pacing device (hereinafter, “LPD”) is configured for implantation in a ventricle of a heart of a patient, and is configured to switch between an atrio-ventricular synchronous pacing mode and an asynchronous ventricular pacing mode in response to detection of one or more sensing events, which may be, for example, undersensing events. In some examples, an LPD is configured to switch from a sensing without pacing mode to an atrio-ventricular synchronous pacing mode in response to determining, for a threshold number of cardiac cycles, a ventricular depolarization was not detected within a ventricular event detection window that begins at an atrial activation event.

Claims

1. A method comprising:

sensing an electrical cardiac signal using a leadless pacing device while the leadless pacing device is in an atrio-ventricular synchronous pacing mode;

receiving, by a processing module, the electrical cardiac signal sensed by the leadless pacing device while the leadless pacing device is in the atrio-ventricular synchronous pacing mode;

detecting, by a processing module, a first atrial activation event;

determining, by a processing module and based on the electrical cardiac signal, a second atrial activation event was not detected within a detection window that begins at the first atrial activation event; and

controlling, by the processing module, the leadless pacing device to deliver pacing pulses to a ventricle of a patient according to an asynchronous ventricular pacing mode based on the determination that the second atrial activation event was not detected within the detection window.

2. The method of claim 1, wherein controlling the leadless pacing device to deliver pacing pulses according to the asynchronous ventricular pacing mode based on the determination that the second atrial activation event was not detected within the detection window further comprises:

in response to determining the second atrial activation event was not detected within the detection window, incrementing a counter;

after incrementing the counter, determining, by the processing module, whether a value of the counter is greater than or equal to a threshold value; and

in response to determining the value of the counter is greater than or equal to a threshold value, controlling, by the processing module, the leadless pacing device to deliver pacing pulses in the asynchronous ventricular pacing mode.

3. The method of claim 2, wherein the threshold value is one.

4. The method of claim 2, wherein the threshold value is two or three.

5. The method of claim 1, wherein the electrical cardiac signal comprises a first electrical cardiac signal, the method further comprising determining the detection window, wherein determining the detection window comprises:

sensing a second electrical cardiac signal using the leadless pacing device prior to sensing the first electrical cardiac signal;

receiving, by the processing module, the second electrical cardiac signal sensed by the leadless pacing device prior to sensing the first electrical cardiac signal;

detecting, by the processing module and based on the second electrical cardiac signal, a plurality of atrial activation events;

determining intervals between each consecutive two atrial activation events of the plurality of atrial activation events; and

determining, by the processing module, an average length of the interval between each consecutive two atrial activation events of the plurality of atrial activation events, wherein a duration of the detection window is based on the average length of the interval.

6. The method of claim 1, wherein the electrical cardiac signal comprises a first electrical cardiac signal, the method further comprising determining the detection window, wherein determining the detection window comprises:

sensing a second electrical cardiac signal using the leadless pacing device prior to sensing the first electrical cardiac signal;

receiving, by the processing module, the second electrical cardiac signal sensed by the leadless pacing device prior to sensing the first electrical cardiac signal;

detecting, based on the second electrical cardiac signal, a first ventricular activation event;

detecting, based on the second electrical cardiac signal, a second ventricular activation event, the second ventricular activation event being a next ventricular activation event after the first ventricular activation event; and

determining an interval between the first and second ventricular activation events, wherein a duration of the detection window is based on the interval between the first and second ventricular activation events.

7. The method of claim 1, further comprising:

detecting, by the processing module and based on the sensed electrical cardiac signal, a first ventricular activation event; and

detecting, by the processing module based on the sensed electrical cardiac signal, a second ventricular activation event, wherein determining the second atrial activation event was not detected within the detection window further comprises determining the second atrial activation event was not detected between the first and second ventricular activation events.

8. The method of claim 1, further comprising controlling, by the processing module, the leadless pacing device to deliver pacing pulses to the patient in the atrio-ventricular synchronous pacing mode, wherein controlling the leadless pacing device to deliver the pacing pulses to the patient in the atrio-ventricular synchronous pacing mode comprises:

detecting a third atrial activation event; and

controlling the leadless pacing device to deliver a pacing pulse to the ventricle of the patient a predetermined time period after the third atrial activation event.

9. The method of claim 1, wherein the detection window is a first detection window, wherein controlling the leadless pacing device to deliver the pacing pulses to the patient in the asynchronous ventricular pacing mode further comprises:

detecting a ventricular activation event;

determining whether intrinsic depolarization of the ventricle is detected within a second detection window that begins at the ventricular activation event; and

in response to intrinsic depolarization of the ventricle is not detected within the second detection window, controlling the leadless pacing device to deliver a pacing pulse to the ventricle.

10. The method of claim 1, wherein the asynchronous ventricular pacing mode is rate-adaptive.

11. The method of claim 1, further comprising:

detecting, by the leadless pacing device, a plurality of ventricular activation events; and

determining, by a processing module, an average VV interval based on the plurality of ventricular activation events, wherein, when the leadless pacing device is in the asynchronous ventricular pacing mode, the leadless pacing device delivers pacing pulses to a ventricle of a patient at a rate equal to the average VV interval plus an offset.

12. A leadless pacing system comprising:

a leadless pacing device configured to sense an electric cardiac signal and configured to deliver pacing therapy to a heart of a patient; and

a processing module configured to;

detect, based on the electric cardiac signal and while the leadless pacing device is in an atrio-ventricular synchronous pacing mode, a first atrial activation event,

determine, based on the electric cardiac signal, a second atrial activation event was not detected within a detection window that begins at the first atrial activation event, and

control the leadless pacing device to deliver pacing pulses to a ventricle of the patient according to an asynchronous ventricular pacing mode based on the determination that the second atrial activation event was not detected within the detection window.

13. The system of claim 12, wherein the processing module is configured to control the leadless pacing device to deliver pacing pulses according to the asynchronous ventricular pacing mode by at least:

in response to determining the second atrial activation event was not detected within the detection window, incrementing a counter;

after incrementing the counter, determining, by the processing module, whether a value of the counter is greater than or equal to a threshold value; and

in response to determining the value of the counter is greater than or equal to a threshold value, controlling, by the processing module, the leadless pacing device to deliver pacing pulses in the asynchronous ventricular pacing mode.

14. The system of claim 13, wherein the threshold value is one.

15. The system of claim 13, wherein the threshold value is two or three.

16. The system of claim 12, wherein the electrical cardiac signal comprises a first electrical cardiac signal, wherein the leadless pacing device is configured to sense a second electrical cardiac signal prior to sensing the first cardiac signal, and wherein the processing module is configured to determine the detection window by at least:

detecting, based on the second electrical cardiac signal, a plurality of atrial activation events;

determining intervals between each consecutive two atrial activation events of the plurality of atrial activation events; and

determining an average length of the interval between each consecutive two atrial activation events of the plurality of atrial activation events, wherein a duration of the detection window is based on the average length of the interval.

17. The system of claim 12, wherein the electrical cardiac signal comprises a first electrical cardiac signal, wherein the leadless pacing device is configured to sense a second electrical cardiac signal prior to sensing the first cardiac signal, and wherein the processing module is configured to determine the detection window by at least:

detecting, based on the second electrical cardiac signal, a first ventricular activation event;

detecting, based on the second electrical cardiac signal, a second ventricular activation event, the second ventricular activation event being a next ventricular activation event after the first ventricular activation event; and

determining an interval between the first and second ventricular activation events, wherein a duration of the detection window is based on the interval between the first and second ventricular activation events.

18. The system of claim 12, wherein the processing module is configured to:

detecting, based on the sensed electrical cardiac signal, a first ventricular activation event; and

detecting, based on the sensed electrical cardiac signal, a second ventricular activation event, wherein the processing module is configured to determine the second atrial activation event was not detected within the detection window comprises by at least determining the second atrial activation event was not detected between the first and second ventricular activation events.

19. The system of claim 12, wherein the processing module is configured to control the leadless pacing device to deliver pacing pulses to the patient in the atrio-ventricular synchronous pacing mode by at least:

detecting a third atrial activation event; and

controlling the leadless pacing device to deliver a pacing pulse to the ventricle of the patient a predetermined time period after the third atrial activation event.

20. The system of claim 12, wherein the detection window is a first detection window, and wherein the processing module is configured to control the leadless pacing device to deliver pacing pulses to the patient in the asynchronous ventricular pacing mode by at least:

detecting a ventricular activation event;

determining whether intrinsic depolarization of the ventricle is detected within a second detection window that begins at the ventricular activation event; and

in response to intrinsic depolarization of the ventricle is not detected within the second detection window, controlling the leadless pacing device to deliver a pacing pulse to the ventricle.

21. The system of claim 12, wherein the asynchronous ventricular pacing mode is rate-adaptive.

22. The system of claim 12, wherein the processing module is configured to detect a plurality of ventricular activation events, determine an average VV interval based on the plurality of ventricular activation events, control the leadless pacing device to deliver pacing pulses according to the asynchronous ventricular pacing mode at a rate equal to the average VV interval plus an offset.

23. A non-transitory computer-readable storage medium comprising instructions that, when executed by a processing module, cause the processing module to:

detect, based on an electrical cardiac signal sensed by a leadless pacing device while the leadless pacing device is in an atrio-ventricular synchronous pacing mode, a first atrial activation event;

determine, based on the electrical cardiac signal, a second atrial activation event was not detected within a detection window that begins at the first atrial activation event; and

control the leadless pacing device to deliver pacing pulses to a ventricle of a patient according to an asynchronous ventricular pacing mode based on the determination that the second atrial activation event was not detected within the detection window.