Transcranial magnetic stimulation for altering susceptibility of tissue to pharmaceuticals and radiation
First Claim
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1. A method of increasing the effect of a drug upon a targeted area of a patient'"'"'s tissue by transcranial magnetic stimulation (TMS), the method comprising:
- delivering a drug that reaches a target tissue via blood vessels to the patient;
steering a TMS electromagnet to deliver a first magnetic field energy to the target tissue, wherein the first magnetic field energy has a low frequency of 5 Hz or less, wherein the TMS electromagnet is oriented so that an induced current in the target tissue or a principle current at an apex of the TMS electromagnet is oriented transversely to an anterior to posterior (AP) axis of the patient'"'"'s head; and
applying the first magnetic field energy to increase perfusion of the target tissue, so that availability of drug to the target tissue is increased.
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Abstract
Described herein are methods for modulating the susceptibility of one or more target or tissue regions, and particularly one or more brain regions, to a therapeutic agent such as a drug, immune agent, compound, radiation, etc. In particular, the methods and systems described herein may include magnetic stimulation (including transcranial magnetic stimulation) of target or non-target regions to modulate the susceptibility of the one or more target or tissue regions to a therapeutic agent.
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Citations
17 Claims
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1. A method of increasing the effect of a drug upon a targeted area of a patient'"'"'s tissue by transcranial magnetic stimulation (TMS), the method comprising:
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delivering a drug that reaches a target tissue via blood vessels to the patient; steering a TMS electromagnet to deliver a first magnetic field energy to the target tissue, wherein the first magnetic field energy has a low frequency of 5 Hz or less, wherein the TMS electromagnet is oriented so that an induced current in the target tissue or a principle current at an apex of the TMS electromagnet is oriented transversely to an anterior to posterior (AP) axis of the patient'"'"'s head; and applying the first magnetic field energy to increase perfusion of the target tissue, so that availability of drug to the target tissue is increased. - View Dependent Claims (2, 3, 4, 5, 6)
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7. A method for increasing the effect of a drug upon a targeted area of a patient'"'"'s tissue by transcranial magnetic stimulation (TMS), the method comprising:
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delivering a drug that reaches a target tissue via blood vessels to the patient; steering a TMS electromagnet to deliver a first magnetic field energy to the target tissue; applying the first magnetic field energy to the target tissue to increase perfusion of the target tissue, so that availability of the drug to the target tissues is increased; and applying a second magnetic field energy to a non-target tissue to decrease perfusion of the non-target tissue, so that availability of the drug to the non-target tissue is reduced, wherein the first magnetic field energy has a low frequency of 5 Hz or less, wherein the TMS electromagnet is oriented so that an induced current from the TMS electromagnet is oriented transversely to an anterior to posterior (AP) axis of the patient'"'"'s head. - View Dependent Claims (8, 9, 10)
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11. A method of increasing the effect of a drug upon a targeted area of a patient'"'"'s head by transcranial magnetic stimulation (TMS), the method comprising:
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delivering a drug that reaches a target tissue via blood vessels to the patient; steering a plurality of TMS electromagnets to deliver a first magnetic field energy to the target tissue, wherein the first magnetic field energy has a low frequency of 5 Hz or less, wherein the TMS electromagnet is oriented so that an induced current in the target tissue or a principle current at an apex of at least one of the TMS electromagnets is oriented transversely to an anterior to posterior (AP) axis of the patient'"'"'s head; and applying the first magnetic field energy to increase perfusion of the target tissue, so that availability of drug to the target tissue is increased.
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12. A method of increasing the effect of a drug upon a targeted area of a patient'"'"'s tissue by transcranial magnetic stimulation (TMS), the method comprising:
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delivering a drug that reaches a target tissue via blood vessels to the patient; steering a TMS electromagnet to deliver a first magnetic field energy to the target tissue, wherein the first magnetic field energy has a low frequency of 5 Hz or less, wherein the TMS electromagnet is oriented so that a current induced from the TMS electromagnet is oriented transversely to an anterior to posterior (AP) axis of the patient'"'"'s head; and applying the first magnetic field energy to increase perfusion of the target tissue, so that availability of drug to the target tissue is increased. - View Dependent Claims (13, 14, 15, 16, 17)
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Specification