Device and method for treatment of cells and cell tissue

• US 9,492,681 B2
• Filed: 01/16/2012
• Issued: 11/15/2016
• Est. Priority Date: 02/14/2011
• Status: Expired due to Fees

• Current Assignee: Merck Patent GmbH (Merck & Co., Inc.)
• Original Assignee: Merck Patent GmbH (Merck & Co., Inc.)
• Inventors: Aydt, Ewald, Buchholz, Herwig, Pan, Junyou
• Primary Examiner(s): Thomson, William
• Assistant Examiner(s): Lipitz, Jeffrey
• Application Number:
  US13/985,209
• Publication Number:
  US 20130324909A1
• Time in Patent Office: 1,765 Days
• Field of Search: 607/88, 607/89, 604/20
• US Class Current: 1/1
• CPC Class Codes: A61F 9/00834 Inlays; Onlays; Intraocular lenses [IOL]
• CPC Class Codes: A61N 2005/0653 Organic light emitting diodes
• CPC Class Codes: A61N 2005/0654 Lamps
• CPC Class Codes: A61N 2005/0656 Chemical light sources
• CPC Class Codes: A61N 2005/0659 infrared
• CPC Class Codes: A61N 2005/0661 ultraviolet
• CPC Class Codes: A61N 2005/0662 Visible light
• CPC Class Codes: A61N 5/06 using light
• CPC Class Codes: A61N 5/0616 Skin treatment other than tanning
• CPC Class Codes: A61N 5/062 Photodynamic therapy, i.e. excitation of an agent
• CPC Class Codes: A61P 17/02 for treating wounds, ulcers, burns, scars, keloids, or the like
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: H10K 50/00 Organic light-emitting devices integrated devices or assemblies of multiple devices H10K59/00, H10K65/00; organic semiconductor lasers H01S5/36
• CPC Class Codes: H10K 50/115 comprising active inorganic nanostructures, e.g. luminescent quantum dots
• CPC Class Codes: H10K 50/135 comprising mobile ions

Abstract

The present invention relates to a cells and cell tissue treatment device and use thereof.

Claims

1. A cell and/or cell tissue treatment device, comprising at least one light source selected from the group consisting of an organic light emitting electrochemical cell (OLEC) and a light emitting electrochemical cell including at least one quantum dot (QD-LEC).

2. The device according to claim 1, characterized in that the at least one element chosen from OLEC, QD-LEC is adapted for activation, stimulation, deactivation, disinfection, depilation, phototherapy, extracorporeal treatment, and/or intracorporeal treatment of cells and/or cell tissue, and/or lifting of cell tissue.

3. The device according to claim 1, characterized in that the at least one element chosen from OLEC, QD-LEC is adapted to emit multichromatic and/or narrowband light and/or light in the yellow wavelength range and/or light in the infrared wavelength range;

and/or wherein the cells and/or cell tissue treatment device is a continuous wave and/or pulsed device.

4. The device according to claim 3, characterized in that the at least one element chosen from OLEC, QD-LEC is adapted to emit a multichromatic light having an effective radiated power ratio of about 4:

1 of yellow light to infrared light; and

/or to emit a multichromatic light including yellow light of about 590 nm at an effective radiated power of about 4 mW/cm² and infrared light of about 850 nm at an effective radiated power of about 1 mW/cm².

5. The device according to claim 1, characterized in that the at least one element chosen from OLEC, QD-LEC is adapted to emit light at a wavelength from about 300 nm to about 1300 nm, and/or at a total energy fluence of less than 10 J/cm2, and/or at pulses having a duration of from about 0.1 femtoseconds to about 100 seconds, and/or the interpulse delay being between said pulses being from about 0.1 to about 1000 milliseconds.

6. The device according to claim 1 comprising at least one element chosen from an ultrasound source, filter means adapted for reducing the intensity of infrared radiation received by the cells and/or cell tissue, filter means for selecting a wavelength or a wavelength band, and cooling means.

7. The device according to claim 1, characterized in that the cells or cells of the cell tissue are at least one element chosen from plant cells, animal cells, human cells, mammalian cells, eucaryotic cells, procaryotic cells, hair cells, hair root cells, skin cells, mucosal cells, and stem cells.

8. A method of cosmetic treatment;

prophylactic treatment;

therapeutic treatment;

non-invasive treatment;

activation, stimulation, deactivation, disinfection, depilation, phototherapy, photodynamic therapy, extracorporeal treatment, intracorporeal treatment of cells and/or cell tissue;

peeling and/or lifting of cell tissue; and

/or activation or inhibition of the differentiation of stem cells comprising utilizing the device according to claim 1.

9. The method according to claim 8, characterized in that the cells or cells of the cell tissue are at least one element chosen from plant cells, animal cells, human cells, mammalian cells, eucaryotic cells, procaryotic cells, hair cells, hair root cells, skin cells, mucosal cells, and stem cells.

10. The method according to claim 8, characterized in that the cosmetic treatment is directed to the treatment and/or prophylaxis of acne and wrinkles of the skin.

11. A method for treatment of cells and/or cell tissue, comprising exposing cells or cell tissue to light emitted from a device according to claim 1.

12. The method according to claim 11, characterized in that the step of exposing cells or cell tissue to light includes emitting multichromatic and/or narrowband light and/or light in the yellow wavelength range and/or light in the infrared wavelength range.

13. The method according to claim 11, characterized in that the step of exposing cells or cell tissue to light includes emitting multichromatic light having a effective radiated power ratio of about 4:

1 of yellow light to infrared light; and

/or wherein the step of exposing cells or cell tissue to light includes emitting multichromatic light including yellow light of about 590 nm at an effective radiated power of about 4 mW/cm² and infrared light of about 850 nm at an effective radiated power of about 1 mW/cm2.

14. The method according to claim 11, comprising applying a topical composition or a topical chromophore composition to the cells or cell tissue before, during or after exposing the cells or the cell tissue to the light.

15. The method according to claim 14, characterized in that the topical composition or the topical chromophore composition is encapsulated or microencapsulated in a vehicle;

and/or

wherein the topical composition includes at least one element chosen from naturally occurring chlorophyll-containing compounds, carotenoid-containing compounds, phyocobilin compounds, indocyanine green, methylene blue, rose Bengal, Vitamin C, Vitamin E, Vitamin D, Vitamin A, Vitamin K, Vitamin F, Retin A (Tretinoin), Adapalene, Retinol, Hydroquinone, Kojic acid, a growth factor, echinacea, an antibiotic, an antifungal, an antiviral, a bleaching agent, an alpha hydroxy acid, a beta hydroxy acid, salicylic acid, antioxidant triad compound, a seaweed derivative, a salt water derivative, algae, an antioxidant, a phytoanthocyanin, a phytonutrient, plankton, a botanical product, a herbaceous product, a hormone, an enzyme, a mineral, a cofactor, an antiaging substance, insulin, minoxidil, lycopene, a natural or synthetic melanin, a metalloproteinase inhibitor, proline, hydroxyproline, an anesthetic, chlorophyll, bacteriochlorophyll, copper chlorophyllin, chloroplasts, carotenoids, phycobilin, rhodopsin, anthocyanin, inhibitors of omithine decarboxylase, inhibitors of vascular endothelial growth factor (VEGF), inhibitors of phospholipase A2, inhibitors of S-adenosylmethionine, licorice, licochalone A, genestein, soy isoflavones, phtyoestrogens, derivative, analogs, homologs, and subcomponents thereof, and derivatives, subcomponents, immunological complexes and antibodies of said cells or cell tissue, and synthetic and natural analogs thereof, combinations thereof; and

/or

wherein the topical chromophore composition has at least one absorption maximum between 300 nm and 1300 nm and includes an active ingredient selected from the group consisting of chlorophyll, porphyrin, and combinations thereof, wherein the active ingredient has at least one metal-ligand bond, wherein the metal in the metal-ligand bond is selected from the group consisting of Fe, Mg, Cu, Al, reactive transition metals, metal chelates, and antibody complexes.

16. The method according to claim 11, characterized in that by exposing the cells or the cell tissue to the light at least one element chosen from cosmetic treatment;

prophylactic treatment;

therapeutic treatment;

non-invasive treatment;

activation, stimulation, deactivation, disinfection, depilation, phototherapy, photodynamic therapy, extracorporeal treatment, intracorporeal treatment of cells and/or cell tissue;

peeling or lifting of cell tissue; and

/or activation or inhibition of the differentiation of stem cells is performed.

17. The method according to claim 11, characterized in that the cells or the cells of the cell tissue are at least one element chosen from plant cells, animal cells, human cells, mammalian cells, eucaryotic cells, procaryotic cells, hair cells, hair root cells, skin cells, mucosal cells, and stem cells.

18. The method according to claim 11, characterized in that the treatment is no treatment of the human or animal body by surgery or therapy and/or is not practised on the human or animal body.