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System for detection of spaced droplets

  • US 9,492,797 B2
  • Filed: 01/20/2014
  • Issued: 11/15/2016
  • Est. Priority Date: 09/23/2008
  • Status: Active Grant
First Claim
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1. A method of detection for droplet-based assays, the method comprising:

  • placing an open end of a channel network into an emulsion;

    driving droplets of the emulsion along a flow path from the open end, through a confluence region where a dilution fluid is introduced into the flow path from at least one dilution inlet channel to increase an average distance between droplets, and through an examination region disposed downstream of the confluence region; and

    detecting light from the examination region as droplets pass through;

    wherein the channel network includes a droplet inlet channel that meets the at least one dilution inlet channel at the confluence region, and wherein the droplet inlet channel forms a tapered region that is sized such that droplets leave the tapered region in single file.

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