Super-hydrophilic structures

• US 9,492,952 B2
• Filed: 03/30/2012
• Issued: 11/15/2016
• Est. Priority Date: 08/30/2010
• Status: Active Grant

• Current Assignee: Agency For Science Technology and Research, Endo-Surgery, Inc.
• Original Assignee: Agency For Science Technology and Research, Endo-Surgery, Inc.
• Inventors: Luong-Van, Emma Kim, Rodriguez, Isabel, Low, Hong Yee, Elmouelhi, Noha, Cooper, Kevin, Natarajan, Sriram, Vyakarnam, Murty N., Lim, Chee Tiong
• Primary Examiner(s): Sample, David
• Assistant Examiner(s): Flores, Jr., Donald M
• Application Number:
  US13/435,544
• Publication Number:
  US 20120251611A1
• Time in Patent Office: 1,691 Days
• Field of Search: None
• US Class Current: 1/1
• CPC Class Codes: A61B 2017/00871 polymeric
• CPC Class Codes: A61B 2017/00938 hydrophobic
• CPC Class Codes: A61B 2017/00942 hydrophilic
• CPC Class Codes: A61B 2017/00951 adhesive
• CPC Class Codes: A61L 27/18 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
• CPC Class Codes: A61L 31/06 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds A61L31/041 takes precedence
• CPC Class Codes: B29C 33/52 soluble or fusible in particular used in injection moulding B29C45/4457
• CPC Class Codes: C08L 67/04 Polyesters derived from hydroxycarboxylic acids, e.g. lactones C08L67/06 takes precedence
• CPC Class Codes: Y10T 428/24355 Continuous and nonuniform or irregular surface on layer or component [e.g., roofing, etc.]

Abstract

A polydioxanone film comprising substantially cylindrical polydioxanone pillars on at least one side thereof, said pillars having diameters from about 0.2 μm to about 3 μm, and heights from about 2 μm to about 20 μm from the surface of the film, a process for adsorbing proteins using the film and medical devices incorporating the film.

Claims

1. A polydioxanone film comprising polydioxanone pillars having circular cross-sections integrally molded with and extending from the surface of at least one side of said film, said pillars having diameters from about 0.2 μ

m to about 3 μ

m, and heights of from about 2 μ

m to about 20 μ

m from the surface of the film, wherein the polydioxanone pillars demonstrate super-hydrophilicity.

2. The polydioxanone film of claim 1, wherein the pillars are treated with an oxygen plasma to increase the oxygen content of said polydioxanone pillars, relative to untreated polydioxanone pillars.

3. The polydioxanone film of claim 2, wherein the polydioxanone pillars have heights of about 20 μ

m from the surface of the film, having a static water contact angle of less than about 10°

.

4. The polydioxanone film of claim 1, wherein the polydioxanone pillars have diameters from about 0.6 μ

m to about 1 μ

μ

m, heights of about 20 μ

m from the surface of the film, having a static water contact angle of less than about 10°

.

5. The polydioxanone film of claim 1, which has a protein adsorption capacity from about 2.5 μ

g/cm² to about 6.0 μ

g/cm² of the film surface.

6. The polydioxanone film of claim 5, which has a protein adsorption capacity from about 4.0 μ

g/cm² to about 6.0 μ

g/cm² of the film surface.

7. A process for adsorbing proteins, comprising exposing a protein-containing solution to a polydioxanone film comprising polydioxanone pillars having circular cross-sections integrally molded with and extending from the surface of at least one side of said film, said pillars having diameters from about 0.2 μ

m to about 3 μ

m, and heights from about 2 μ

m to about 20 μ

m from the surface of the film, wherein the polydioxanone pillars demonstrate super-hydrophilicity.

8. The process of claim 7, wherein the pillars are treated with an oxygen plasma to increase the oxygen content of said polydioxanone pillars, relative to untreated polydioxanone pillars.

9. The process of claim 7, wherein the polydioxanone pillars have diameters from about 0.6 μ

m to about 1 μ

m, heights of about 20 μ

m from the surface of the film, having a static water contact angle of less than about 10°

.

10. The process of claim 8, wherein the polydioxanone pillars have heights of about 20 μ

m from the surface of the film, having a static water contact angle of less than about 10°

.

11. The process of claim 7, wherein the polydioxanone film has a protein adsorption capacity from about 2.5 μ

g/cm² to about 6.0 μ

g/cm² of the film surface.

12. The process of claim 11, wherein the polydioxanone film has a protein adsorption capacity from about 4.0 μ

g/cm² to about 6.0 μ

g/cm² of the film surface.

13. A medical device comprising a polydioxanone film comprising polydioxanone pillars having circular cross-sections integrally molded with and extending from the surface of at least one side of said film, said pillars having a diameter from about 0.2 μ

m to about 3 μ

m, and a height of up to about 2 μ

m to about 20 μ

m from the surface of the film, wherein the polydioxanone pillars demonstrate super-hydrophilicity.

14. The medical device of claim 13, which has improved biocompatibility as compared to an implant device without said film.

15. The medical device of claim 13, which has an increased capacity for protein adsorption as compared to a flat polydioxanone film.