Diazaspirocycloalkane and azaspirocycloalkane

• US 9,493,486 B2
• Filed: 12/12/2014
• Issued: 11/15/2016
• Est. Priority Date: 06/13/2012
• Status: Active Grant

• Current Assignee: Hoffmann-La Roche Incorporated (Roche Holding AG)
• Original Assignee: Hoffmann-La Roche Incorporated (Roche Holding AG)
• Inventors: Hunziker, Daniel, Mattei, Patrizio, Mauser, Harald, Prunotto, Marco, Ullmer, Christoph
• Primary Examiner(s): DESAI, RITA J
• Application Number:
  US14/569,564
• Publication Number:
  US 20150099734A1
• Time in Patent Office: 704 Days
• Field of Search: 546/16, 548/147, 548/216, 548/255, 548/953, 514/210.18, 514/210.17
• US Class Current: 1/1
• CPC Class Codes: A61P 1/16 for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
• CPC Class Codes: A61P 13/12 of the kidneys
• CPC Class Codes: A61P 19/02 for joint disorders, e.g. arthritis, arthrosis
• CPC Class Codes: A61P 25/00 Drugs for disorders of the nervous system
• CPC Class Codes: A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: A61P 35/00 Antineoplastic agents
• CPC Class Codes: A61P 37/06 Immunosuppressants, e.g. drugs for graft rejection
• CPC Class Codes: C07D 205/12 condensed with carbocyclic rings or ring systems
• CPC Class Codes: C07D 249/18 Benzotriazoles
• CPC Class Codes: C07D 401/10 linked by a carbon chain containing aromatic rings
• CPC Class Codes: C07D 401/12 linked by a chain containing hetero atoms as chain links
• CPC Class Codes: C07D 403/10 linked by a carbon chain containing aromatic rings
• CPC Class Codes: C07D 403/12 linked by a chain containing hetero atoms as chain links
• CPC Class Codes: C07D 405/06 linked by a carbon chain containing only aliphatic carbon atoms
• CPC Class Codes: C07D 405/12 linked by a chain containing hetero atoms as chain links
• CPC Class Codes: C07D 413/12 linked by a chain containing hetero atoms as chain links
• CPC Class Codes: C07D 471/10 Spiro-condensed systems
• CPC Class Codes: C07D 487/10 Spiro-condensed systems
• CPC Class Codes: C07D 519/00 Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Abstract

The invention provides novel compounds having the general formula (I)

wherein R¹, R², Y and W are as described herein, compositions including the compounds and methods of using the compounds.

Claims

1. A compound of formula (I)

2. A The compound of claim 1, wherein R⁸ is haloalkoxy, halogen or alkylsulfonyl.

3. A The compound of claim 1, wherein R⁹ is alkyl, haloalkyl or halogen.

4. The compound of claim 1, wherein R¹⁰ is H.

5. The compound of claim 1, selected from:

6. The compound of claim 5, selected from: